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Nalbuphine and morphine
Nalbuphine and morphine are opioid agonists that bind to opioid receptors in the central nervous system to produce analgesia and pain relief.
Nalbuphine and morphine are opioid agonists that bind to opioid receptors in the central nervous system to produce analgesia and pain relief. Used for Moderate to severe pain management, Postoperative pain.
At a glance
| Generic name | Nalbuphine and morphine |
|---|---|
| Sponsor | National Taiwan University Hospital |
| Drug class | Opioid analgesic combination |
| Target | Opioid receptors (mu, kappa, delta) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Nalbuphine is a mixed opioid agonist-antagonist that acts primarily as a kappa receptor agonist and mu receptor antagonist, while morphine is a mu opioid receptor agonist. When used in combination, they work synergistically to provide pain relief through activation of opioid receptors in the brain and spinal cord, modulating pain perception and transmission.
Approved indications
- Moderate to severe acute pain
- Postoperative pain management
Common side effects
- Respiratory depression
- Nausea and vomiting
- Dizziness
- Sedation
- Constipation
- Pruritus
Key clinical trials
- Intravenous Nalbuphine for Prevention of Intrathecal Morphine-induced Nausea and Vomiting in Patients Undergoing Cesarean Section: A Double-blind, Randomized Controlled Trial. (NA)
- Postoperative Pain Management of Caesarean Section
- Evaluation of Safety and Efficacy of Nalbuphine Versus Morphine for Postoperative Analgesia (PHASE3)
- Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
- The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial (PHASE2, PHASE3)
- Using of Virtual Reality to Relieve Procedural Pain in Pediatric Oncology. (NA)
- Comparison of Morphine With Nalbuphine in a Multimodal Approach for Pain Relief in Patients Undergoing Gynecological Procedures: Randomized Controlled Double Blind Clinical Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nalbuphine and morphine CI brief — competitive landscape report
- Nalbuphine and morphine updates RSS · CI watch RSS
- National Taiwan University Hospital portfolio CI