Botanical/nutraceutical antioxidant

This page covers all Botanical/nutraceutical antioxidant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting COX-2 (meloxicam); cartilage matrix precursor (glucosamine), Multiple: GPR120, GPR40, PPAR-γ, LXR; membrane incorporation.

Targets

COX-2 (meloxicam); cartilage matrix precursor (glucosamine) · Multiple: GPR120, GPR40, PPAR-γ, LXR; membrane incorporation

Marketed (11)

• Grape Seed Extract · Al-Azhar University · Cardiovascular, Antioxidant/Anti-inflammatory
  Grape seed extract exerts antioxidant and anti-inflammatory effects through polyphenolic compounds, primarily proanthocyanidins, which scavenge free radicals and modulate inflammatory pathways.
• Polyunsaturated Fatty Acids · Hadir F. El-Dessouky · Cardiovascular
  Polyunsaturated fatty acids (PUFAs) modulate inflammatory pathways and support cellular membrane integrity to reduce cardiovascular and metabolic disease risk.
• Resveratrol plus Carboxymethyl-β-Glucan · Istituto per la Ricerca e l'Innovazione Biomedica · Immunology / Wellness
  Resveratrol and carboxymethyl-β-glucan work synergistically to provide antioxidant and immunomodulatory effects.
• N-acetyl-D-glucosamine · Third Military Medical University · Rheumatology / Orthopedics
  N-acetyl-D-glucosamine is a naturally occurring amino sugar that supports joint cartilage structure and may reduce inflammatory markers associated with joint degradation.
• HydroEye® · University of Alabama at Birmingham · Ophthalmology
  HydroEye® is an oral nutritional supplement containing omega-3 fatty acids and other nutrients designed to support tear film stability and reduce dry eye symptoms.
• Onion peel extract · Kyunghee University Medical Center · Metabolic/Inflammatory conditions
  Onion peel extract contains quercetin and other polyphenols that exert antioxidant and anti-inflammatory effects through free radical scavenging and modulation of inflammatory pathways.
• Rutin + Vitamin C · Ain Shams University · Cardiovascular / Vascular health
  Rutin and Vitamin C work synergistically as antioxidants to reduce oxidative stress and strengthen vascular integrity through free radical scavenging and collagen stabilization.
• Glucosamine/Chondroitin · Indus Hospital and Health Network · Rheumatology / Orthopedics
  Glucosamine and chondroitin are structural components of cartilage that may help maintain joint cartilage integrity and reduce cartilage degradation in osteoarthritis.
• Flax oil · University of Rochester · Cardiovascular / Wellness
  Flax oil provides omega-3 and omega-6 polyunsaturated fatty acids that support cardiovascular and inflammatory health.
• Grape Extract · University of Mississippi Medical Center · Cardiovascular, Antioxidant/Anti-inflammatory
  Grape extract provides antioxidant and anti-inflammatory effects through polyphenols, particularly resveratrol and proanthocyanidins, which scavenge free radicals and modulate inflammatory pathways.
• Rubus occidentalis extract · Korea University Anam Hospital · Preventive health / Oncology (investigational)
  Rubus occidentalis (black raspberry) extract contains polyphenols and anthocyanins that exert antioxidant and anti-inflammatory effects to support cellular health.

Phase 3 pipeline (11)

• Evening primrose oil(EPO) · Ain Shams University · Rheumatology; Immunology; Inflammatory disorders
  Evening primrose oil provides gamma-linolenic acid (GLA), a polyunsaturated fatty acid that is converted to anti-inflammatory metabolites, primarily dihomo-gamma-linolenic acid (DGLA) and arachidonic acid derivatives.
• Glucosamine sulfate + chondroitin sulfate - CONDROFLEX · Mantecorp Industria Quimica e Farmaceutica Ltd. · Rheumatology/Orthopedics
  Glucosamine sulfate and chondroitin sulfate work together to provide substrate for cartilage synthesis and reduce cartilage degradation in osteoarthritis.
• Vayarin®, supplementation of n-3 PUFA · Hospices Civils de Lyon · Neurology
  Vayarin® provides a targeted delivery of n-3 polyunsaturated fatty acids (PUFAs) to support brain health and function.
• Meloxicam and Glucosamine · Zodiac Produtos Farmaceuticos S.A. · Rheumatology / Orthopedics
  Meloxicam reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while glucosamine supports cartilage structure and may reduce joint degradation.
• glucosamine sulfate /chondroitin sulfate - capsules · Ache Laboratorios Farmaceuticos S.A. · Rheumatology/Orthopedics
  Glucosamine sulfate and chondroitin sulfate work together to provide substrates for cartilage matrix synthesis and may reduce cartilage degradation in osteoarthritis.
• Cosamin DS® · Ache Laboratorios Farmaceuticos S.A. · Rheumatology/Orthopedics
  Cosamin DS provides glucosamine and chondroitin sulfate to support cartilage structure and reduce joint degradation in osteoarthritis.
• Cosamin DS® (Nutramax) · Eurofarma Laboratorios S.A. · Rheumatology / Orthopedics
  Cosamin DS is a dietary supplement containing glucosamine and chondroitin that may help maintain cartilage structure and reduce joint inflammation in osteoarthritis.
• Polyunsaturated fatty acids omega-3 · Hospital San Juan de la Cruz · Cardiovascular
  Omega-3 polyunsaturated fatty acids reduce triglycerides and modulate inflammatory pathways by incorporating into cell membranes and competing with pro-inflammatory arachidonic acid metabolites.
• Medox® Anthocyanin capsules · Sun Yat-sen University · Cardiovascular, Metabolic, or General wellness (specific indication unclear)
  Anthocyanins exert antioxidant and anti-inflammatory effects by scavenging free radicals and modulating inflammatory pathways.
• glucosamine and chondroitin sulfate combined · US Department of Veterans Affairs · Rheumatology/Orthopedics
  Glucosamine and chondroitin sulfate work together to provide substrate for cartilage repair and reduce cartilage degradation in osteoarthritis.
• Fatty Acids, Unsaturated · Wroclaw Medical University · Cardiovascular
  Unsaturated fatty acids modulate inflammatory pathways and cellular membrane composition to reduce cardiovascular and metabolic dysfunction.

Patent intelligence

• nutraceutical patent landscape — aggregated cliff calendar, attackable patents, originator estates