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Polyunsaturated fatty acids omega-3
Omega-3 polyunsaturated fatty acids reduce triglycerides and modulate inflammatory pathways by incorporating into cell membranes and competing with pro-inflammatory arachidonic acid metabolites.
Omega-3 polyunsaturated fatty acids reduce triglycerides and modulate inflammatory pathways by incorporating into cell membranes and competing with pro-inflammatory arachidonic acid metabolites. Used for Hypertriglyceridemia, Cardiovascular disease prevention, Post-myocardial infarction secondary prevention.
At a glance
| Generic name | Polyunsaturated fatty acids omega-3 |
|---|---|
| Sponsor | Hospital San Juan de la Cruz |
| Drug class | Lipid-modifying agent; nutraceutical |
| Target | Multiple: GPR120, GPR40, PPAR-γ, LXR; membrane incorporation |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Omega-3 PUFAs (EPA and DHA) are incorporated into phospholipid membranes where they displace arachidonic acid, reducing production of pro-inflammatory eicosanoids and cytokines. They also activate G-protein coupled receptors and nuclear receptors (PPAR-γ, LXR) that suppress inflammatory gene expression and improve lipid metabolism, particularly reducing plasma triglycerides.
Approved indications
- Hypertriglyceridemia
- Cardiovascular disease prevention
- Post-myocardial infarction secondary prevention
Common side effects
- Gastrointestinal upset (nausea, dyspepsia, diarrhea)
- Fishy aftertaste or eructation
- Bleeding or bruising (at high doses)
- Headache
Key clinical trials
- n-3 Polyunsaturated Fatty Acids to Prevent and Treat Diabetic Neuropathy (NA)
- Observing Metabolism of EPA With Consideration of Genetics And Sex (PHASE4)
- NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status (NA)
- Omega-3 Supplementation for Pediatric Migraine (NA)
- Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers (NA)
- Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients (PHASE2)
- Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in New-born Infants (NA)
- Effect of Consuming n-3 PUFAs Rich Foods on Triglyceride Concentration and Lipoprotein Composition (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |