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Grape Seed Extract
Grape seed extract exerts antioxidant and anti-inflammatory effects through polyphenolic compounds, primarily proanthocyanidins, which scavenge free radicals and modulate inflammatory pathways.
Grape seed extract exerts antioxidant and anti-inflammatory effects through polyphenolic compounds, primarily proanthocyanidins, which scavenge free radicals and modulate inflammatory pathways. Used for Cardiovascular health and endothelial function support, Antioxidant and anti-inflammatory support, Chronic venous insufficiency (in some formulations).
At a glance
| Generic name | Grape Seed Extract |
|---|---|
| Also known as | GSE |
| Sponsor | Al-Azhar University |
| Drug class | Botanical/nutraceutical antioxidant |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular, Antioxidant/Anti-inflammatory |
| Phase | FDA-approved |
Mechanism of action
Grape seed extract contains high concentrations of proanthocyanidins and other polyphenols that act as potent antioxidants, neutralizing reactive oxygen species and reducing oxidative stress. These compounds also inhibit inflammatory mediators and enzymes involved in inflammation, potentially providing cardioprotective, neuroprotective, and anti-aging benefits. The extract may also modulate endothelial function and vascular tone through effects on nitric oxide pathways.
Approved indications
- Cardiovascular health and endothelial function support
- Antioxidant and anti-inflammatory support
- Chronic venous insufficiency (in some formulations)
Common side effects
- Headache
- Dizziness
- Nausea
- Dry mouth
Key clinical trials
- Effectiveness of a Grape Seed Extract on Circulatory Measures in Healthy Adults (PHASE3)
- Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy (PHASE2)
- Leucoselect Phytosome for Neoadjuvant Treatment of Early Stage Lung Cancer (PHASE2)
- Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin (NA)
- Study to Investigate the Potential Health Benefits of Grapes Seeds Extract Supplementation in the Management of Elevated Blood Pressure or Stage 1 Hypertension (NA)
- Hemodynamic Effects of a Standardized Grape Seed Extract Supplementation (NA)
- Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication (NA)
- Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Grape Seed Extract CI brief — competitive landscape report
- Grape Seed Extract updates RSS · CI watch RSS
- Al-Azhar University portfolio CI