{"id":"grape-seed-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL2108130","moleculeType":"Unknown"},"_dailymed":{"setId":"8bf57652-5750-4111-acef-45c5fdc676af","title":"SKINUVA BRUISE (ARNICA MONTANA, BROMELAIN, GRAPE SEED EXTRACT, VITAMIN C, RUTIN, ZINC OXIDE, CELLULOSE) CAPSULE [MD MEDICAL DESIGNS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Grape seed extract contains high concentrations of proanthocyanidins and other polyphenols that act as potent antioxidants, neutralizing reactive oxygen species and reducing oxidative stress. These compounds also inhibit inflammatory mediators and enzymes involved in inflammation, potentially providing cardioprotective, neuroprotective, and anti-aging benefits. The extract may also modulate endothelial function and vascular tone through effects on nitric oxide pathways.","oneSentence":"Grape seed extract exerts antioxidant and anti-inflammatory effects through polyphenolic compounds, primarily proanthocyanidins, which scavenge free radicals and modulate inflammatory pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:15.668Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiovascular health and endothelial function support"},{"name":"Antioxidant and anti-inflammatory support"},{"name":"Chronic venous insufficiency (in some formulations)"}]},"trialDetails":[{"nctId":"NCT06440252","phase":"PHASE3","title":"Effectiveness of a Grape Seed Extract on Circulatory Measures in Healthy Adults","status":"COMPLETED","sponsor":"RDC Clinical Pty Ltd","startDate":"2024-10-31","conditions":"Circulatory; Change","enrollment":35},{"nctId":"NCT02946996","phase":"PHASE2","title":"Study of Pharmacologic 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Used for Cardiovascular health and endothelial function support, Antioxidant and anti-inflammatory support, Chronic venous insufficiency (in some formulations).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}