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N-acetyl-D-glucosamine
N-acetyl-D-glucosamine is a naturally occurring amino sugar that supports joint cartilage structure and may reduce inflammatory markers associated with joint degradation.
N-acetyl-D-glucosamine is a naturally occurring amino sugar that supports joint cartilage structure and may reduce inflammatory markers associated with joint degradation. Used for Osteoarthritis, Joint pain and inflammation, Cartilage support.
At a glance
| Generic name | N-acetyl-D-glucosamine |
|---|---|
| Also known as | Atysamine(ATSM), Atysamine (ATSM) |
| Sponsor | Third Military Medical University |
| Drug class | Dietary supplement / Nutraceutical |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
N-acetyl-D-glucosamine (NAG) is a precursor to glycosaminoglycans and proteoglycans, key structural components of cartilage and connective tissue. It is proposed to provide substrate for cartilage synthesis and may modulate inflammatory pathways involved in joint disease. The compound is thought to support joint integrity and reduce symptoms associated with osteoarthritis and joint inflammation.
Approved indications
- Osteoarthritis
- Joint pain and inflammation
- Cartilage support
Common side effects
- Gastrointestinal upset
- Nausea
- Headache
Key clinical trials
- Oral N-acetylglucosamine in Crohn's Disease (PHASE2)
- A Trial of a Multi-Component Nutritional Supplement in Hydrogen-Dominant Small Intestinal Bacterial Overgrowth (NA)
- Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation (NA)
- Study on Structum® in Adult Patients With Osteoarthritis (TRUST)
- Effect of Shockwaves on Fallopian Tubes Adhesion (NA)
- Effect of Hyaluronic Acid Oral Supplementation on Sexual and Urinary Symptoms of Women With Recurrent Urinary Tract Infections (NA)
- Hyaluronic Acid Gel in Ridge Preservation (PHASE4)
- Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- N-acetyl-D-glucosamine CI brief — competitive landscape report
- N-acetyl-D-glucosamine updates RSS · CI watch RSS
- Third Military Medical University portfolio CI