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Onion peel extract
Onion peel extract is a Botanical extract / Polyphenol-based nutraceutical Small molecule drug developed by Kyunghee University Medical Center. It is currently FDA-approved for Metabolic syndrome and related conditions (marketed/traditional use). Also known as: OPE.
Onion peel extract contains quercetin and other polyphenols that exert antioxidant and anti-inflammatory effects through free radical scavenging and modulation of inflammatory pathways.
Onion peel extract has been studied in clinical trials for its potential effects on upper respiratory infections and immune system enhancement. According to ChEMBL, onion peel extract acts as a blocker of the voltage-sensitive sodium channel alpha-subunit.
At a glance
| Generic name | Onion peel extract |
|---|---|
| Also known as | OPE |
| Sponsor | Kyunghee University Medical Center |
| Drug class | Botanical extract / Polyphenol-based nutraceutical |
| Modality | Small molecule |
| Therapeutic area | Metabolic/Inflammatory conditions |
| Phase | FDA-approved |
Mechanism of action
Onion peel is rich in flavonoids, particularly quercetin, which act as potent antioxidants by neutralizing reactive oxygen species and reducing oxidative stress. These compounds also inhibit pro-inflammatory cytokine production and may modulate signaling pathways involved in inflammation, potentially providing therapeutic benefits in conditions characterized by oxidative stress and chronic inflammation.
Approved indications
- Metabolic syndrome and related conditions (marketed/traditional use)
Common side effects
- Gastrointestinal upset
- Allergic reactions (rare)
Key clinical trials
- Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement (NA)
- Effects of Onion Peel Extract on Endothelial Function (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Onion peel extract CI brief — competitive landscape report
- Onion peel extract updates RSS · CI watch RSS
- Kyunghee University Medical Center portfolio CI
Frequently asked questions about Onion peel extract
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Related
- Drug class: All Botanical extract / Polyphenol-based nutraceutical drugs
- Manufacturer: Kyunghee University Medical Center — full pipeline
- Therapeutic area: All drugs in Metabolic/Inflammatory conditions
- Indication: Drugs for Metabolic syndrome and related conditions (marketed/traditional use)
- Also known as: OPE
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing