{"id":"onion-peel-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":{"chemblId":"CHEMBL2108766","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Onion peel is rich in flavonoids, particularly quercetin, which act as potent antioxidants by neutralizing reactive oxygen species and reducing oxidative stress. These compounds also inhibit pro-inflammatory cytokine production and may modulate signaling pathways involved in inflammation, potentially providing therapeutic benefits in conditions characterized by oxidative stress and chronic inflammation.","oneSentence":"Onion peel extract contains quercetin and other polyphenols that exert antioxidant and anti-inflammatory effects through free radical scavenging and modulation of inflammatory pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:58:23.262Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metabolic syndrome and related conditions (marketed/traditional use)"}]},"trialDetails":[{"nctId":"NCT05666752","phase":"NA","title":"Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement","status":"UNKNOWN","sponsor":"Hanyang University","startDate":"2022-11-07","conditions":"Upper Respiratory Infection","enrollment":80},{"nctId":"NCT02180022","phase":"PHASE4","title":"Effects of Onion Peel Extract on Endothelial Function","status":"COMPLETED","sponsor":"Kyunghee University Medical Center","startDate":"2013-04","conditions":"Healthy, Overweight, Obese","enrollment":62}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":67,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["OPE"],"phase":"marketed","status":"active","brandName":"Onion peel extract","genericName":"Onion peel extract","companyName":"Kyunghee University Medical Center","companyId":"kyunghee-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Onion peel extract has been studied in clinical trials for its potential effects on upper respiratory infections and immune system enhancement. According to ChEMBL, onion peel extract acts as a blocker of the voltage-sensitive sodium channel alpha-subunit.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}