NCT02180022 is a Phase 4 clinical trial of Onion peel extract in Healthy, sponsored by Kyunghee University Medical Center.

Who is sponsoring NCT02180022?

NCT02180022 is sponsored by Kyunghee University Medical Center.

What drugs are being tested in NCT02180022?

Interventions in NCT02180022: Placebo, Onion peel extract.

What condition does NCT02180022 study?

NCT02180022 studies Healthy, Overweight, Obese.

Is NCT02180022 still recruiting?

NCT02180022 is currently completed. Last updated 1 July 2014.

Last reviewed 2014-07-01 · How we verify

NCT02180022

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Onion Peel Extract on Endothelial Function and Endothelial Progenitor Cells in Overweight and Obese Subjects

Completed Phase 4 Last updated 1 July 2014

What this trial tests

Phase 4 trial testing Placebo in Healthy in 62 participants. Completed in 1 December 2013.

Timeline

1 April 2013

Primary endpoint
1 December 2013

1 December 2013

Quick facts

Lead sponsor	Kyunghee University Medical Center
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	supportive care
Enrollment	62
Start date	1 April 2013
Primary completion	1 December 2013
Estimated completion	1 December 2013
Sites	1 location across South Korea

Drugs / interventions tested

Placebo
Onion peel extract — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →
Overweight — all drugs for Overweight →
Obese — all drugs for Obese →

Sponsor

Kyunghee University Medical Center

Who can join

Adults 20 to 60, any sex, with Healthy or Overweight. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

The difference of endothelial function
Time frame: 12 weeks after study drug treatment
The difference of forearm FMD (flow meidated dilation) achieved following study drug treatment

Sponsor's own description

Acute or chronic intake of polyphenol-rich foods has been reported to improve endothelial function. Quercetin, found abundantly in onion, is a potent antioxidant flavonoid. This study was designed to investigate whether consumption of onion peel extract (OPE) improves endothelial function in healthy overweight and obese subjects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks.
Vishwas S, Kumar R, Khursheed R, Ramanunny AK, et al · · 2023 · cited 15× · PMID 35950245 · DOI 10.2174/1570159x20666220810105421

Verify or expand the search:

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Other Kyunghee University Medical Center trials

Trials by the same sponsor.

NCT06183697 — Multi-omics Database Construction of Healthy Korean Volunteers · recruiting
NCT06113497 — A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty · Phase 4 · unknown
NCT06049914 — Combined Exercise and Nutrition Intervention for Possible Sarcopenia Among Older Adults in Primary Care · NA · unknown
NCT03515070 — Microbiome and Genetic Analysis of Familial IBD · completed
NCT03589183 — Gut Microbiome in Inflammatory Bowel Disease · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02180022 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kyunghee University Medical Center
Last refreshed: 1 July 2014

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02180022.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing