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glucosamine and chondroitin sulfate combined
glucosamine and chondroitin sulfate combined is a Nutraceutical/Dietary supplement combination Small molecule drug developed by US Department of Veterans Affairs. It is currently in Phase 3 development for Osteoarthritis of the knee, Osteoarthritis of other joints.
Glucosamine and chondroitin sulfate work together to provide substrate for cartilage repair and reduce cartilage degradation in osteoarthritis.
Glucosamine and chondroitin sulfate work together to provide substrate for cartilage repair and reduce cartilage degradation in osteoarthritis. Used for Osteoarthritis of the knee, Osteoarthritis of other joints.
At a glance
| Generic name | glucosamine and chondroitin sulfate combined |
|---|---|
| Sponsor | US Department of Veterans Affairs |
| Drug class | Nutraceutical/Dietary supplement combination |
| Modality | Small molecule |
| Therapeutic area | Rheumatology/Orthopedics |
| Phase | Phase 3 |
Mechanism of action
Glucosamine is a precursor for glycosaminoglycan synthesis, which is essential for cartilage matrix formation and repair. Chondroitin sulfate is a major component of cartilage that helps retain water and resist compression, while also inhibiting enzymes that break down cartilage. Together, they aim to slow cartilage degeneration and potentially promote cartilage regeneration in degenerative joint disease.
Approved indications
- Osteoarthritis of the knee
- Osteoarthritis of other joints
Common side effects
- Gastrointestinal upset
- Nausea
- Headache
- Rash
Key clinical trials
- NT-II™ Collagen for Joint Discomfort and Function (NA)
- Evaluate the Effect of Dietary Supplement Combined Exercise Among Patients With Sarcopenia Comorbid With Lung Disease (NA)
- A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study (PHASE3)
- GLUCOSAMINE/CHONDROITIN and PHYSICAL THERAPY EFFECTS ON OLDER POPULATION WITH KNEE OSTEOARTHRITIS (NA)
- Treatment and Companion Diagnostics of Lower Back Pain Using SCENAR and Passive Medical Radiometry (MWR) (NA)
- Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfate Supplementation in Addition to Exercise and Physical Therapy in the Management of Knee Osteoarthritis. (NA)
- Efficacy of Focused Shock Waves Combined With Adjuvant Therapy With Tendon Supplement (NA)
- Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- glucosamine and chondroitin sulfate combined CI brief — competitive landscape report
- glucosamine and chondroitin sulfate combined updates RSS · CI watch RSS
- US Department of Veterans Affairs portfolio CI
Frequently asked questions about glucosamine and chondroitin sulfate combined
What is glucosamine and chondroitin sulfate combined?
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Related
- Drug class: All Nutraceutical/Dietary supplement combination drugs
- Manufacturer: US Department of Veterans Affairs — full pipeline
- Therapeutic area: All drugs in Rheumatology/Orthopedics
- Indication: Drugs for Osteoarthritis of the knee
- Indication: Drugs for Osteoarthritis of other joints
- Compare: glucosamine and chondroitin sulfate combined vs similar drugs
- Pricing: glucosamine and chondroitin sulfate combined cost, discount & access