Herbal extract / Natural product

This page covers all Herbal extract / Natural product drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Na+/K+-ATPase; multiple apoptotic pathways, HMG-CoA reductase, PPAR-α, PPAR-γ, LDL receptor, NF-κB, multiple targets (non-selective).

Targets

Na+/K+-ATPase; multiple apoptotic pathways · HMG-CoA reductase, PPAR-α, PPAR-γ, LDL receptor · NF-κB, multiple targets (non-selective) · Pattern recognition receptors (Dectin-1, TLR); macrophage and NK cell activation · NF-κB, multiple antioxidant pathways · Phospholipase A2, melittin, multiple immune cell receptors · Glucocorticoid receptor; phospholipase A2

Marketed (17)

• Z. officinale extract · Fundação Educacional Serra dos Órgãos · Gastroenterology / Anti-inflammatory
  Zingiber officinale (ginger) extract exerts anti-inflammatory and antioxidant effects through inhibition of prostaglandin and leukotriene synthesis and free radical scavenging.
• Cinobufacini Injection · Dongfang Hospital Beijing University of Chinese Medicine · Oncology
  Cinobufacini is a bufadienolide compound derived from toad venom that inhibits cell proliferation and induces apoptosis in cancer cells through multiple pathways.
• andrographolide sulfonate simulation · Jiangxi Qingfeng Pharmaceutical Co. Ltd. · Immunology; Infectious Disease
  Andrographolide sulfonate is a water-soluble derivative of andrographolide that exerts anti-inflammatory and immunomodulatory effects through multiple cellular pathways.
• Propolis 20% · Dow University of Health Sciences · Dermatology, Wound Care, Oral Health
  Propolis 20% is a natural bee product that exerts antimicrobial, anti-inflammatory, and antioxidant effects through its polyphenolic and flavonoid constituents.
• Manuka honey · University of Zagreb · Dermatology / Wound Care
  Manuka honey exerts antimicrobial and anti-inflammatory effects through its high methylglyoxal content and other bioactive compounds, promoting wound healing and tissue repair.
• bee venom · Assistance Publique - Hôpitaux de Paris · Immunology, Rheumatology
  Bee venom contains multiple bioactive peptides and enzymes that modulate immune function and reduce inflammation through activation of anti-inflammatory pathways and immune cell regulation.
• Bergamot Oil · Wake Forest University Health Sciences · Cardiovascular
  Bergamot oil contains polyphenolic compounds that reduce cholesterol synthesis and improve lipid metabolism through multiple pathways including HMG-CoA reductase inhibition and PPAR activation.
• Honey Mouthwash · Ain Shams University · Oral Health / Dentistry
  Honey mouthwash provides antimicrobial and anti-inflammatory effects in the oral cavity through honey's natural enzymatic and polyphenolic components.
• Liposomal curcumin · University of Florida · Oncology; Inflammation; Nutraceutical
  Liposomal curcumin delivers the polyphenol curcumin in lipid nanoparticles to improve bioavailability and enable anti-inflammatory and antioxidant effects.
• curcumin paste · Ain Shams University · Anti-inflammatory/Antioxidant
  Curcumin is a polyphenolic compound that exerts anti-inflammatory and antioxidant effects by inhibiting multiple signaling pathways including NF-κB and reducing reactive oxygen species.
• Medicinal honey · Henry Ford Health System · Dermatology / Wound Care
  Medicinal honey promotes wound healing and antimicrobial activity through enzymatic production of hydrogen peroxide, osmotic effects, and bioactive compounds.
• thyme honey mouth rinse · Ain Shams University · Oral and Dental Health
  Thyme honey mouth rinse exerts antimicrobial and anti-inflammatory effects in the oral cavity through the bioactive compounds in thyme and honey.
• Centella asiatica · Başakşehir Çam & Sakura City Hospital · Dermatology / Wound Care
  Centella asiatica (Gotu Kola) enhances collagen synthesis and promotes wound healing through its bioactive triterpenes and flavonoids.
• Stingless bee honey (Kelulut) · Universiti Sains Malaysia · Wound healing, Immunology, Gastroenterology
  Stingless bee honey (Kelulut) exerts therapeutic effects through its rich polyphenol and antioxidant content, which reduces oxidative stress and modulates inflammatory pathways.
• Barberry tablet · Birjand University of Medical Sciences · Gastroenterology / Traditional Medicine
  Barberry tablet contains berberine and other alkaloids that exert antimicrobial, anti-inflammatory, and antioxidant effects through multiple cellular pathways.
• Aloe Vera · Government Dental College and Research Institute, Bangalore · Dermatology
  Aloe vera contains polysaccharides and bioactive compounds that promote wound healing, reduce inflammation, and stimulate tissue repair through moisturization and antimicrobial activity.
• ginsenoside RE · Washington University School of Medicine · General wellness/Adaptogenic
  Ginsenoside RE is a natural triterpenoid saponin from ginseng that modulates multiple cellular pathways including stress response, anti-inflammatory, and antioxidant mechanisms.

Phase 3 pipeline (11)

• Micro-particle Curcumin · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Inflammatory diseases / Oncology
  Micro-particle curcumin is a formulation of the natural polyphenol curcumin designed to improve bioavailability and enhance anti-inflammatory and antioxidant effects in the body.
• Extract of Agaricus blazei Murill · ECbiotech Taiwan · Oncology; Immunology
  Agaricus blazei Murill extract enhances immune function through polysaccharide and beta-glucan components that activate macrophages, natural killer cells, and other innate immune cells.
• Extract Psidii guava · Faculty of Medicine Baiturrahmah University · Metabolic / Endocrinology
  Psidium guava extract exerts therapeutic effects through its polyphenolic and antioxidant constituents, which reduce oxidative stress and modulate inflammatory pathways.
• DLBS3233 · Dexa Medica Group · Hepatology / Gastroenterology
  DLBS3233 is a bioactive fraction derived from Cinnamomum burmannii that modulates lipid metabolism and reduces hepatic steatosis through multiple pathways.
• Curcumin Lozenges · Tata Memorial Centre · Oncology, Oral health, Anti-inflammatory
  Curcumin, the active compound from turmeric, exerts anti-inflammatory and antioxidant effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokine production.
• HUACHANSU PIAN · Beijing Shenogen Biomedical Co., Ltd · Oncology
  Huachansu is a traditional Chinese medicine extract derived from toad secretions that contains bufadienolides and other bioactive compounds with potential anti-tumor and immunomodulatory properties.
• Extract from Hintonia latiflora bark · Harras Pharma Curarina GmbH · Cardiovascular
  Hintonia latiflora bark extract contains alkaloids that act as antiarrhythmic agents, primarily through cardiac electrophysiological effects.
• St. John's Wort extract · Cassella-med GmbH & Co. KG · Psychiatry
  St. John's Wort extract acts as a natural antidepressant by increasing levels of neurotransmitters like serotonin, dopamine, and norepinephrine in the brain.
• Arnica Tincture · Universidad de Antioquia · Dermatology / Wound healing / Musculoskeletal
  Arnica tincture reduces inflammation and promotes tissue healing through compounds that inhibit inflammatory mediators and stimulate blood flow.
• Apitox - pure honeybee toxin · Apimeds, Inc. · Immunology / Rheumatology
  Apitoxin, the active component of honeybee venom, exerts anti-inflammatory and immunomodulatory effects through phospholipase A2 and other peptide components that modulate immune cell activity and reduce inflammatory mediators.
• Diammonium glycyrrhizinate Capsules · Nanfang Hospital, Southern Medical University · Hepatology; Immunology; Gastroenterology
  Diammonium glycyrrhizinate reduces inflammation and modulates immune responses by enhancing glucocorticoid receptor signaling and suppressing pro-inflammatory cytokine production.

Patent intelligence

• natural product patent landscape — aggregated cliff calendar, attackable patents, originator estates