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Diammonium glycyrrhizinate Capsules
Diammonium glycyrrhizinate Capsules is a Natural product-derived anti-inflammatory agent Small molecule drug developed by Nanfang Hospital, Southern Medical University. It is currently in Phase 3 development for Chronic hepatitis B, Liver inflammation and hepatic injury, Autoimmune hepatitis. Also known as: ganlixin capsules.
Diammonium glycyrrhizinate reduces inflammation and modulates immune responses by enhancing glucocorticoid receptor signaling and suppressing pro-inflammatory cytokine production.
Diammonium glycyrrhizinate reduces inflammation and modulates immune responses by enhancing glucocorticoid receptor signaling and suppressing pro-inflammatory cytokine production. Used for Chronic hepatitis B, Liver inflammation and hepatic injury, Autoimmune hepatitis.
At a glance
| Generic name | Diammonium glycyrrhizinate Capsules |
|---|---|
| Also known as | ganlixin capsules |
| Sponsor | Nanfang Hospital, Southern Medical University |
| Drug class | Natural product-derived anti-inflammatory agent |
| Target | Glucocorticoid receptor; phospholipase A2 |
| Modality | Small molecule |
| Therapeutic area | Hepatology; Immunology; Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
Glycyrrhizinate, the active metabolite of licorice root, acts as a mineralocorticoid and glucocorticoid receptor modulator that inhibits phospholipase A2 and reduces production of inflammatory mediators including TNF-α, IL-6, and IL-8. The diammonium salt formulation improves bioavailability and allows oral capsule delivery for systemic anti-inflammatory and hepatoprotective effects.
Approved indications
- Chronic hepatitis B
- Liver inflammation and hepatic injury
- Autoimmune hepatitis
Common side effects
- Hypokalemia
- Hypertension
- Sodium retention
- Gastrointestinal upset
Key clinical trials
- A Multicenter Randomized Open-label Study of Diammonium Glycyrrhizinate Enteric-coated Capsule Plus DXM Versus DXM in Treatment of ITP (PHASE2)
- F573 for Injection for the Treatment of Liver Injury/Failure (PHASE2)
- FDGL Dose-Finding Study for Diabetic Neuropathy (PHASE2)
- A Prospective Cohort Study on Drug-induced Liver Injury in China（DILI-P）
- Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis (NA)
- Efficacy of JAK STAT Pathways Inhibitors in Treatment of Patients With Rheumatoid Arthritis (NA)
- Complementary Intervention for COVID-19 (NA)
- Micronutrient Supplementation in PCO-syndrome (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diammonium glycyrrhizinate Capsules CI brief — competitive landscape report
- Diammonium glycyrrhizinate Capsules updates RSS · CI watch RSS
- Nanfang Hospital, Southern Medical University portfolio CI
Frequently asked questions about Diammonium glycyrrhizinate Capsules
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Related
- Drug class: All Natural product-derived anti-inflammatory agent drugs
- Target: All drugs targeting Glucocorticoid receptor; phospholipase A2
- Manufacturer: Nanfang Hospital, Southern Medical University — full pipeline
- Therapeutic area: All drugs in Hepatology; Immunology; Gastroenterology
- Indication: Drugs for Chronic hepatitis B
- Indication: Drugs for Liver inflammation and hepatic injury
- Indication: Drugs for Autoimmune hepatitis
- Also known as: ganlixin capsules
- Compare: Diammonium glycyrrhizinate Capsules vs similar drugs
- Pricing: Diammonium glycyrrhizinate Capsules cost, discount & access