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Evaluation of the Efficacy of Natural JAK_ STAT Pathways Inhibitors in Treatment of Patients With Rheumatoid Arthritis as a Complementary Medicine
There is no treatment that could utterly cure Rheumatoid arthritis (RA), but the disease is mainly improved by conventional disease-modifying anti rheumatic drugs. Methotrexate and biological DMARDs as JAK-STAT inhibitors may be used to control and delay the progression of the disease and improve the quality of lives of patients. However, DMARDs have deleterious effects on human health. Several natural components have JAK-STAT inhibitory effect such as Boswellic acid (Boswellia serrata extract), Glycyrrhizin (Glycyrrhiza glabra extr.) and Apigenin (Chamomile extr)
Details
| Lead sponsor | Adel A.Gomaa |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 75 |
| Start date | 2023-07 |
| Completion | 2025-12 |
Conditions
- Rheumatoid Arthritis
Interventions
- "apigenin" and "glycyrrhizin"
- "glycyrrhizin" and "boswellic acid"
- "placebo"
Primary outcomes
- The change in DAS28 based on C-reactive protein (DAS28-CRP) — Before the intervention, 3 months after the intervention, and 6 months after the intervention
DAS-28 score: a DAS-28 score \> 5.1 indicating high disease activity; 3.2\< DAS-28 score≤5.1 indicates moderate disease activity; 2.6\< DAS-28 score≤3.2 indicates low disease activity; DAS-28 score≤2.6 indicates basic disease remission