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Bergamot Oil
Bergamot oil contains polyphenolic compounds that reduce cholesterol synthesis and improve lipid metabolism through multiple pathways including HMG-CoA reductase inhibition and PPAR activation.
Bergamot oil contains polyphenolic compounds that reduce cholesterol synthesis and improve lipid metabolism through multiple pathways including HMG-CoA reductase inhibition and PPAR activation. Used for Hyperlipidemia / dyslipidemia, Cardiovascular risk reduction.
At a glance
| Generic name | Bergamot Oil |
|---|---|
| Also known as | Bergamot essential oil, Bergamot, Citrus bergamia |
| Sponsor | Wake Forest University Health Sciences |
| Drug class | Natural product / Botanical extract |
| Target | HMG-CoA reductase, PPAR-α, PPAR-γ, LDL receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Bergamot oil, derived from the Citrus bergamia fruit, contains flavonoids and other polyphenols that modulate lipid homeostasis. The active constituents work through multiple mechanisms including inhibition of cholesterol-synthesizing enzymes, activation of peroxisome proliferator-activated receptors (PPARs), and enhancement of LDL receptor expression, leading to reduced serum cholesterol and triglycerides.
Approved indications
- Hyperlipidemia / dyslipidemia
- Cardiovascular risk reduction
Common side effects
- Gastrointestinal upset
- Photosensitivity (bergapten-related)
- Allergic reactions
Key clinical trials
- Study on the Antidepressant Effects and Mechanism of Action of Cang-ai Volatile Oil Based on Near-Infrared Functional Brain Imaging and the NT-Trk Signalling Pathway (NA)
- Aromatherapy Formulas for Sundowning and Sleep Quality in Patients With Dementia. (NA)
- Effect of Aromatherapy on Anxiety in Colonoscopy Patients (NA)
- Using Aromatherapy in Substance Use Disorder (NA)
- Determining the Efficacy of Essential Oil Aromatherapy in Children Undergoing Port Access (NA)
- The Effect of Aromatherapy Application With Bergamot and Grapefruit Essential Oils on PMS (NA)
- Effects of Aromatherapy Massage in Menopausal Women With Knee Osteoarthritis (NA)
- Effects of Aromatherapy on Anxiety in Invasive Radiologic Procedure (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |