{"id":"bergamot-oil","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Photosensitivity (bergapten-related)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":{"setId":"2613fbda-f95c-01f9-e063-6294a90a8954","title":"TRSTAY BERGAMOT BEARD OIL LIQUID [YIWU ZIQIU IMPORT EXPORT CO LTD]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bergamot oil, derived from the Citrus bergamia fruit, contains flavonoids and other polyphenols that modulate lipid homeostasis. The active constituents work through multiple mechanisms including inhibition of cholesterol-synthesizing enzymes, activation of peroxisome proliferator-activated receptors (PPARs), and enhancement of LDL receptor expression, leading to reduced serum cholesterol and triglycerides.","oneSentence":"Bergamot oil contains polyphenolic compounds that reduce cholesterol synthesis and improve lipid metabolism through multiple pathways including HMG-CoA reductase inhibition and PPAR activation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T05:39:50.077Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyperlipidemia / dyslipidemia"},{"name":"Cardiovascular risk reduction"}]},"trialDetails":[{"nctId":"NCT07384312","phase":"NA","title":"Study on the Antidepressant Effects and Mechanism of Action of Cang-ai Volatile Oil Based on Near-Infrared Functional Brain Imaging and the NT-Trk Signalling Pathway","status":"COMPLETED","sponsor":"Dongdong Qin","startDate":"2023-10-01","conditions":"Depression Disorder","enrollment":60},{"nctId":"NCT07288736","phase":"NA","title":"Aromatherapy Formulas for Sundowning and Sleep Quality in Patients With Dementia.","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cheng-Kung University Hospital","startDate":"2025-09-15","conditions":"Dementia, Sundowning","enrollment":35},{"nctId":"NCT07067424","phase":"NA","title":"Effect of Aromatherapy on Anxiety in Colonoscopy Patients","status":"RECRUITING","sponsor":"Eastern Mediterranean University","startDate":"2025-01-01","conditions":"Anxiety, Colonoscopy, Aromatherapy","enrollment":102},{"nctId":"NCT05660434","phase":"NA","title":"Using Aromatherapy in Substance Use Disorder","status":"COMPLETED","sponsor":"West Virginia University","startDate":"2022-09-05","conditions":"Substance Use Disorders","enrollment":100},{"nctId":"NCT05696899","phase":"NA","title":"Determining the Efficacy of Essential Oil Aromatherapy in Children Undergoing Port Access","status":"COMPLETED","sponsor":"Stanford University","startDate":"2023-12-05","conditions":"Anxiety and Fear, Pain","enrollment":23},{"nctId":"NCT06289764","phase":"NA","title":"The Effect of Aromatherapy Application With Bergamot and Grapefruit Essential Oils on PMS","status":"COMPLETED","sponsor":"Esra ÖZER","startDate":"2024-02-01","conditions":"Premenstrual Syndrome-PMS","enrollment":90},{"nctId":"NCT05823077","phase":"NA","title":"Effects of Aromatherapy Massage in Menopausal Women With Knee Osteoarthritis","status":"COMPLETED","sponsor":"KTO Karatay University","startDate":"2023-05-24","conditions":"Osteoarthritis, Knee","enrollment":60},{"nctId":"NCT03090750","phase":"PHASE1","title":"Effects of Aromatherapy on Anxiety in Invasive Radiologic Procedure","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2015-07-16","conditions":"Anxiety, Anxiety Preoperative","enrollment":31},{"nctId":"NCT05692700","phase":"NA","title":"The Effect of Inhaled Lavender and Bergamot Oil on Anxiety and Sleep Quality in Intensive Care Patients.","status":"COMPLETED","sponsor":"Istanbul University - Cerrahpasa","startDate":"2021-05-02","conditions":"Patient Undergoing Surgery","enrollment":54},{"nctId":"NCT05251779","phase":"EARLY_PHASE1","title":"A Clinical Study on the Effects of Inhalation of Volatile Oil of Cang-Ai Via the Nose on Patients With Depression","status":"UNKNOWN","sponsor":"Jieqiong Cui","startDate":"2022-11-01","conditions":"Depressive Disorder, Mental Disorder in Adolescence","enrollment":60},{"nctId":"NCT04722614","phase":"NA","title":"Music and Essential Oil in Agitation","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2021-04-11","conditions":"Agitation","enrollment":123},{"nctId":"NCT05242523","phase":"NA","title":"Automated Stress Detection and Restoration in Office Workers","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2022-04-01","conditions":"Stress","enrollment":50},{"nctId":"NCT04783714","phase":"NA","title":"Investigating Effects of a Novel Nutraceutical on Hypercholesterolaemia in Australian Adults","status":"COMPLETED","sponsor":"Swisse Wellness Pty Ltd","startDate":"2021-04-30","conditions":"Hypercholesterolemia","enrollment":42},{"nctId":"NCT03858855","phase":"NA","title":"Inhaled Essential Oil Effect on Common QOL Concerns During Cancer Treatment","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2019-02-18","conditions":"Gastrointestinal Cancer, Neuroendocrine Carcinoma, Skin Cancer","enrollment":248},{"nctId":"NCT04321889","phase":"NA","title":"Efficacy of Defurocumarinized Bergamot in the Treatment of Agitation in Severe Dementia Patients.","status":"UNKNOWN","sponsor":"S.Anna Rehabilitation Institute","startDate":"2020-04-01","conditions":"Severe Dementia, Stroke","enrollment":134},{"nctId":"NCT03016221","phase":"NA","title":"Local Changes of Skin Characteristics After an Application of a Topical Product With a Warming or Cooling Effect","status":"COMPLETED","sponsor":"University of Applied Sciences and Arts of Southern Switzerland","startDate":"2017-05-01","conditions":"Healthy","enrollment":90},{"nctId":"NCT04188340","phase":"NA","title":"Effect of Su-Man Formula Massage Oil Acupressure on Sleep Quality and Anxiety in Patients With Insomnia","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2018-04-18","conditions":"Insomnia","enrollment":38},{"nctId":"NCT03818490","phase":"NA","title":"Aromatherapy for Anxiety Among Children With Autism Spectrum Disorder","status":"COMPLETED","sponsor":"Nutraceuticals Research Institute","startDate":"2016-06-24","conditions":"Anxiety, Autism Spectrum Disorder","enrollment":28}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bergamot essential oil","Bergamot","Citrus bergamia"],"phase":"marketed","status":"active","brandName":"Bergamot Oil","genericName":"Bergamot Oil","companyName":"Wake Forest University Health Sciences","companyId":"wake-forest-university-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bergamot oil contains polyphenolic compounds that reduce cholesterol synthesis and improve lipid metabolism through multiple pathways including HMG-CoA reductase inhibition and PPAR activation. Used for Hyperlipidemia / dyslipidemia, Cardiovascular risk reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}