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Liposomal curcumin
Liposomal curcumin delivers the polyphenol curcumin in lipid nanoparticles to improve bioavailability and enable anti-inflammatory and antioxidant effects.
Liposomal curcumin delivers the polyphenol curcumin in lipid nanoparticles to improve bioavailability and enable anti-inflammatory and antioxidant effects. Used for Cancer supportive care and adjunctive therapy, Inflammatory conditions.
At a glance
| Generic name | Liposomal curcumin |
|---|---|
| Also known as | Manna Liposomal Curcumin |
| Sponsor | University of Florida |
| Drug class | Natural product derivative; anti-inflammatory/antioxidant agent |
| Modality | Small molecule |
| Therapeutic area | Oncology; Inflammation; Nutraceutical |
| Phase | FDA-approved |
Mechanism of action
Curcumin is a natural polyphenol from turmeric with pleiotropic biological activities including inhibition of NF-κB signaling, reduction of pro-inflammatory cytokines, and antioxidant effects. The liposomal formulation addresses curcumin's poor oral bioavailability by encapsulating it in lipid vesicles, enhancing cellular uptake and systemic exposure. This allows therapeutic concentrations to be achieved at lower doses.
Approved indications
- Cancer supportive care and adjunctive therapy
- Inflammatory conditions
Common side effects
- Gastrointestinal upset
- Nausea
- Diarrhea
Key clinical trials
- Study of the Safety and Usefulness of Liposomal Curcumin in Multiple Myeloma (PHASE1)
- Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients (PHASE2)
- High-protein Oral Supplement With Liposomal Curcumin in Adults Undergoing Hemodialysis. (PHASE3)
- A Study of Curcumin (Soloways ™) in Patients With Inflammatory Bowel Disease Homozygous for the IL-10 Variant (NA)
- Effectiveness of Curcuminoids in Controlling Postoperative Pain Following Total Laparoscopic Hysterectomy (PHASE4)
- Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas (PHASE1, PHASE2)
- Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis. (NA)
- A Phase IB Dose Escalation Study of Lipocurc in Patients With Cancer (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |