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Curcumin Lozenges
Curcumin, the active compound from turmeric, exerts anti-inflammatory and antioxidant effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokine production.
Curcumin, the active compound from turmeric, exerts anti-inflammatory and antioxidant effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokine production. Used for Oral mucositis prevention and treatment in cancer patients undergoing chemotherapy or radiotherapy, Oral inflammation and antimicrobial applications.
At a glance
| Generic name | Curcumin Lozenges |
|---|---|
| Also known as | Longvida (Pharmanza Herbal Pvt Ltd.) |
| Sponsor | Tata Memorial Centre |
| Drug class | Natural product/polyphenol anti-inflammatory agent |
| Target | NF-κB, multiple antioxidant pathways |
| Modality | Small molecule |
| Therapeutic area | Oncology, Oral health, Anti-inflammatory |
| Phase | Phase 3 |
Mechanism of action
Curcumin is a polyphenolic compound that modulates multiple signaling pathways involved in inflammation and oxidative stress. It acts as a potent antioxidant and inhibits nuclear factor-kappa B (NF-κB) activation, thereby suppressing the expression of inflammatory mediators. The lozenge formulation allows for local delivery and systemic absorption to exert therapeutic effects.
Approved indications
- Oral mucositis prevention and treatment in cancer patients undergoing chemotherapy or radiotherapy
- Oral inflammation and antimicrobial applications
Common side effects
- Gastrointestinal upset
- Staining of oral tissues
- Allergic reactions
Key clinical trials
- Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant (PHASE2)
- Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Curcumin Lozenges CI brief — competitive landscape report
- Curcumin Lozenges updates RSS · CI watch RSS
- Tata Memorial Centre portfolio CI