{"id":"curcumin-lozenges","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Staining of oral tissues"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Curcumin is a polyphenolic compound that modulates multiple signaling pathways involved in inflammation and oxidative stress. It acts as a potent antioxidant and inhibits nuclear factor-kappa B (NF-κB) activation, thereby suppressing the expression of inflammatory mediators. The lozenge formulation allows for local delivery and systemic absorption to exert therapeutic effects.","oneSentence":"Curcumin, the active compound from turmeric, exerts anti-inflammatory and antioxidant effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokine production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:17.729Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral mucositis prevention and treatment in cancer patients undergoing chemotherapy or radiotherapy"},{"name":"Oral inflammation and antimicrobial applications"}]},"trialDetails":[{"nctId":"NCT04870060","phase":"PHASE2","title":"Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant","status":"COMPLETED","sponsor":"Tata Memorial Centre","startDate":"2010-10-06","conditions":"Oral Mucositis (Ulcerative)","enrollment":40},{"nctId":"NCT04896164","phase":"PHASE3","title":"Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting","status":"UNKNOWN","sponsor":"Tata Memorial Centre","startDate":"2018-12-16","conditions":"Oral Mucositis (Ulcerative)","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Longvida (Pharmanza Herbal Pvt Ltd.)"],"phase":"phase_3","status":"active","brandName":"Curcumin Lozenges","genericName":"Curcumin Lozenges","companyName":"Tata Memorial Centre","companyId":"tata-memorial-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Curcumin, the active compound from turmeric, exerts anti-inflammatory and antioxidant effects by inhibiting NF-κB signaling and reducing pro-inflammatory cytokine production. Used for Oral mucositis prevention and treatment in cancer patients undergoing chemotherapy or radiotherapy, Oral inflammation and antimicrobial applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}