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Centella asiatica
Centella asiatica (Gotu Kola) enhances collagen synthesis and promotes wound healing through its bioactive triterpenes and flavonoids.
Centella asiatica (Gotu Kola) enhances collagen synthesis and promotes wound healing through its bioactive triterpenes and flavonoids. Used for Wound healing and tissue repair, Venous insufficiency and lymphedema, Cellulite reduction.
At a glance
| Generic name | Centella asiatica |
|---|---|
| Sponsor | Başakşehir Çam & Sakura City Hospital |
| Drug class | Herbal extract / Natural product |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Wound Care |
| Phase | FDA-approved |
Mechanism of action
The plant extract contains asiaticoside, madecassoside, and other compounds that stimulate fibroblast proliferation and collagen deposition in the skin and connective tissues. These constituents also possess antioxidant and anti-inflammatory properties that reduce tissue damage and support the healing process. The mechanism is primarily supportive rather than targeting a specific molecular receptor.
Approved indications
- Wound healing and tissue repair
- Venous insufficiency and lymphedema
- Cellulite reduction
- Skin health and anti-aging
Common side effects
- Allergic contact dermatitis
- Photosensitivity
- Hepatotoxicity (rare, at high doses)
Key clinical trials
- Safety and Efficacy of Topical Cream for Post-inflammatory Hyperpigmentation Skin Among Malaysians (NA)
- A Study Comparing the Effects of Two Types of Natural Oils Used in a Bedtime Foot Massage Routine on Sleep and Emotional Well-Being in Perimenopausal Women. (NA)
- Clinical Trial to Evaluate Papilocare® Gel Efficacy Into Repairment of Cervical Lesions Caused by HPV (NA)
- Scalp Care Efficacy Evaluation for Premium Revitalizing Elixir (NA)
- Scalp Care Efficacy Evaluation for Premium Scalp Revitalizing Essence (NA)
- Pharmacokinetics of Centella Asiatica in the Elderly (EARLY_PHASE1)
- Evaluate the Efficacy and Safety of Xianglei Tangzu Gao for the Treatment of Wagner Grade II Diabetic Foot Ulcers (PHASE2, PHASE3)
- Safety and Target Engagement of Centella Asiatica in Cognitive Impairment (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |