{"id":"centella-asiatica","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Hepatotoxicity (rare, at high doses)"}]},"_chembl":{"chemblId":"CHEMBL5095437","moleculeType":"Unknown"},"_dailymed":{"setId":"41a127d2-f717-3f9a-e063-6394a90a9123","title":"NEWSKIN WHOLE EMBRYONIC LAYER ANTI-AGING SKIN RENEWAL POWDE (MARITIME PINE, SCHISANDRA CHINENSIS SEED, CENTELLA ASIATICA TRITERPENOIDS) POWDER [JAPAN MEDICAL BIOTECHNOLOGY LIMITED]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The plant extract contains asiaticoside, madecassoside, and other compounds that stimulate fibroblast proliferation and collagen deposition in the skin and connective tissues. These constituents also possess antioxidant and anti-inflammatory properties that reduce tissue damage and support the healing process. The mechanism is primarily supportive rather than targeting a specific molecular receptor.","oneSentence":"Centella asiatica (Gotu Kola) enhances collagen synthesis and promotes wound healing through its bioactive triterpenes and flavonoids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:30:03.933Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue repair"},{"name":"Venous insufficiency and lymphedema"},{"name":"Cellulite reduction"},{"name":"Skin health and anti-aging"}]},"trialDetails":[{"nctId":"NCT05986123","phase":"NA","title":"Safety and Efficacy of Topical Cream for Post-inflammatory Hyperpigmentation Skin Among Malaysians","status":"COMPLETED","sponsor":"USMARI Research & Innovation Centre","startDate":"2023-11-01","conditions":"Healthy","enrollment":25},{"nctId":"NCT07274371","phase":"NA","title":"A Study Comparing the Effects of Two Types of Natural Oils Used in a Bedtime Foot Massage Routine on Sleep and 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Used for Wound healing and tissue repair, Venous insufficiency and lymphedema, Cellulite reduction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}