Calcineurin Inhibitor Immunosuppressant [EPC]

This page covers all Calcineurin Inhibitor Immunosuppressant [EPC] drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, Calcineurin subunit B type 1, Canalicular multispecific organic anion transporter 1, Canalicular multispecific organic anion transporter 2, Interferon gamma.

Targets

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform · Calcineurin subunit B type 1, Canalicular multispecific organic anion transporter 1, Canalicular multispecific organic anion transporter 2 · Interferon gamma · Calcineurin (via FKBP12 binding) · Calcineurin (protein phosphatase 2B) · mTOR; Calcineurin (PP2B) · Calcineurin · Calcineurin; macrophilin-12 · Calcineurin (tacrolimus) and mTOR (sirolimus) · Calcineurin (cyclosporine); mTOR kinase (sirolimus)

Marketed (86)

• Sandimmune · Novartis · Oncology · 1866.0
• Sandimmune · Novartis AG (originally Sandoz) · Immunology · 1866.0
  Calcineurin inhibitor that suppresses T-cell activation by blocking IL-2 transcription, preventing organ transplant rejection.
• Prograf · Astellas Pharma · Immunology · 1600
  Prograf works by inhibiting the activation of T-lymphocytes, a type of immune cell.
• Tacrolimus (Arm B) · Weill Medical College of Cornell University · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing nuclear translocation of NFAT transcription factors.
• Ciclosporin soft capsules · Chinese PLA General Hospital · Immunology
  Ciclosporin is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• Arm 1 Everolimus/Reduced dose tacrolimus · University of Toledo Health Science Campus · Immunology / Transplantation
  Everolimus inhibits mTOR signaling to suppress immune cell proliferation, while reduced-dose tacrolimus inhibits calcineurin to prevent T-cell activation, together reducing organ rejection risk in transplant recipients.
• Cyclosporine 0.05% ophthalmic solution · Samsung Medical Center · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• cyclosporine micro-emulsion · Novartis · Immunology
  Cyclosporine micro-emulsion is an immunosuppressant that inhibits calcineurin, blocking T-cell activation and proliferation.
• Elidel-Creme · Technische Universität Dresden · Dermatology/Immunology
  Elidel (pimecrolimus) is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.
• Tacrolimus, Reddy Laboratory · University of Cincinnati · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing nuclear translocation of NFAT transcription factors.
• TacroBell SR cap. · Chong Kun Dang Pharmaceutical · Immunology
  TacroBell SR is a sustained-release formulation of tacrolimus that suppresses T-cell activation and proliferation by inhibiting calcineurin phosphatase.
• Cyclosporine 0.05% · Ophthalmic Consultants of Long Island · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• Tacrolimus Ointment 0.03% · Astellas Pharma Inc · Dermatology/Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and cytokine production to reduce skin inflammation.
• Tacrolimus prolonged-release formulation · Astellas Pharma China, Inc. · Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, thereby preventing immune rejection.
• Tacrolimus and Sirolimus · Foundation for Liver Research · Immunology / Transplantation
  Tacrolimus and sirolimus are immunosuppressive agents that inhibit T-cell activation and proliferation through different pathways to prevent organ rejection.
• tacrolimus ointment 0.1% · Hospital de Clinicas de Porto Alegre · Dermatology/Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and cytokine production to reduce skin inflammation.
• CNI (50%) · Hoffmann-La Roche · Immunology
  CNI (calcineurin inhibitor) suppresses T-cell activation by inhibiting calcineurin phosphatase, thereby reducing production of pro-inflammatory cytokines.
• Cyclosporine Injection (IV) · Berinstein, Jeffrey · Immunology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• LCP-tacrolimus · University Hospital Tuebingen · Immunology
  LCP-tacrolimus is a lipid-conjugated prodrug of tacrolimus that inhibits calcineurin to suppress T-cell activation and proliferation.
• Oral Tab Tacrolimus · NephroNet, Inc. · Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, thereby preventing the transcription of pro-inflammatory cytokines.
• Tacrolimus sustained-release capsule · Astellas Pharma China, Inc. · Immunology
  Tacrolimus inhibits calcineurin phosphatase, suppressing T-cell activation and proliferation to prevent organ rejection and treat autoimmune conditions.
• Tacrolimus/Sirolimus · University of Miami · Immunology / Transplantation
  Tacrolimus and sirolimus are immunosuppressive agents that inhibit T-cell activation and proliferation through different pathways to prevent organ rejection.
• Tacrolimus - Prograf® twice daily formulation · University of British Columbia · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation to suppress the immune response.
• Calcineurin Inhibitor · Milton S. Hershey Medical Center · Immunology
  Calcineurin inhibitors block the phosphatase enzyme calcineurin, preventing T cell activation and proliferation by inhibiting the transcription of pro-inflammatory cytokines.
• Tacrolimus (Arm A) · Weill Medical College of Cornell University · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing transcription of IL-2 and other cytokine genes.
• Cyclosporine ophthalmic solution, 0.1% · Novaliq GmbH · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• Prograf (SOC) · University of Alberta · Immunology
  Prograf (tacrolimus) inhibits calcineurin phosphatase, suppressing T-cell activation and proliferation to prevent organ rejection.
• Tacrolimus - Advagraf® once daily formulation · University of British Columbia · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation to suppress immune responses.
• Cyclosporin (CSA) · Eastern Cooperative Oncology Group · Immunology
  Cyclosporin is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• Neoral/Sirolimus · University of Miami · Immunology / Transplantation
  Sirolimus inhibits mTOR kinase to suppress T-cell proliferation and immune activation, while Neoral (cyclosporine) blocks calcineurin to prevent T-cell activation.
• Ciclosporin A (CsA) · Nanfang Hospital, Southern Medical University · Immunology
  Ciclosporin A inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.
• Tacrolimus targeted half-dose · University Hospital, Tours · Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines, thereby reducing immune rejection.
• Cyclosporins/Tacrolimus · University of Minnesota · Immunology
  Cyclosporins and tacrolimus suppress the immune system by inhibiting calcineurin, a key enzyme required for T-cell activation and cytokine production.
• Low Tacrolimus · Ronaldo de Matos Esmeraldo, MD · Immunology
  Low-dose tacrolimus is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, thereby reducing immune-mediated rejection and inflammation.
• Elidel · Bausch Health · Immunology
  Elidel works by inhibiting calcineurin, a protein that helps activate T-cells, which are involved in the allergic response.
• immediate-release tacrolimus · University of Minnesota · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation to suppress immune responses.
• pimecrolimus active cream · Children's Hospital of Michigan · Dermatology / Immunology
  Pimecrolimus is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.
• XR-tacrolimus QD + MMF BID then MMF QD · University Hospital, Limoges · Immunology / Transplantation
  This combination regimen suppresses T-cell activation and proliferation to prevent organ transplant rejection.
• reducing Tacrolimus · Rabin Medical Center · Immunology / Transplantation
  Reducing tacrolimus dosage lowers the immunosuppressive burden in transplant recipients to minimize drug-related toxicity while maintaining graft tolerance.
• XR-tacrolimus QD + MMF BID · University Hospital, Limoges · Immunology / Transplantation
  XR-tacrolimus and MMF work together as immunosuppressants to prevent organ rejection by inhibiting T-cell activation and proliferation.

Phase 3 pipeline (38)

• Calcineurin inhibitors maintenance · Assistance Publique - Hôpitaux de Paris · Immunology
  Calcineurin inhibitors suppress T-cell activation by blocking calcineurin phosphatase, preventing IL-2 production and T-cell proliferation.
• CsA-PG Ophthalmic Gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Ophthalmology
  CsA-PG is a cyclosporine A prodrug formulated as an ophthalmic gel that suppresses local immune responses in the eye to treat dry eye disease.
• Tacrolimus modified-release · Hospital de Clinicas de Porto Alegre · Immunology
  Tacrolimus modified-release works by inhibiting calcineurin, which is involved in the activation of T-lymphocytes.
• Elidel (pimecrolimus 1%) · St Joseph University, Beirut, Lebanon · Dermatology / Immunology
  Pimecrolimus is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.
• Cyclosporin or tacrolimus · Wyeth is now a wholly owned subsidiary of Pfizer · Immunology
  Cyclosporin and tacrolimus are calcineurin inhibitors that suppress T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• Masked Ikervis · Santen SAS · Ophthalmology
  Ikervis is a cyclosporine A ophthalmic emulsion that suppresses local immune-mediated inflammation in the ocular surface.
• CyclASol topical ocular, eye drops · Novaliq GmbH · Ophthalmology
  CyclASol is a cyclosporine A formulation in a novel aqueous nanomicellar vehicle designed to enhance corneal penetration and treat dry eye disease by suppressing ocular surface inflammation.
• Protopic (R) · University Hospital, Rouen · Dermatology/Immunology
  Protopic (tacrolimus) is a calcineurin inhibitor that suppresses T-cell activation and cytokine production to reduce inflammatory skin responses.
• Advagraf QD · Rabin Medical Center · Immunology / Transplantation
  Advagraf QD is a once-daily extended-release formulation of tacrolimus that suppresses T-cell activation by inhibiting calcineurin phosphatase.
• NOVA22007 ''Ciclosporin'' · Santen SAS · Immunology
  Ciclosporin suppresses T-cell activation and proliferation by inhibiting calcineurin, thereby reducing inflammatory immune responses.
• Voclosporin（QL1074） · Qilu Pharmaceutical Co., Ltd. · Immunology
  Voclosporin is an immunosuppressant that inhibits calcineurin.
• LEO 43204 gel · LEO Pharma · Dermatology
  LEO 43204 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
• LEO 80185 gel · LEO Pharma · Dermatology
  LEO 80185 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
• Cyclosporin, low dose steroid · Kyungpook National University Hospital · Immunology
  Cyclosporin suppresses T-cell activation and cytokine production, while low-dose steroids provide additional anti-inflammatory effects to reduce immune-mediated tissue damage.
• Cyclosporine A 0,05% eye drop · Campus Bio-Medico University · Ophthalmology / Immunology
  Cyclosporine A suppresses T-cell activation and reduces inflammatory cytokine production in the eye, thereby decreasing ocular surface inflammation.
• Cyclosporine Vehicle · Allergan · Ophthalmology / Immunology
  Cyclosporine is an immunosuppressant that inhibits T-cell activation by blocking calcineurin, thereby reducing inflammatory responses in the eye.
• NOVA22007 (Ciclosporin 0.1%) · Santen SAS · Ophthalmology
  Ciclosporin is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• FK506E · Astellas Pharma Europe Ltd. · Immunology
  FK506E is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, preventing IL-2 production and T-cell proliferation.
• CsA Ophthalmic Gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Ophthalmology
  CsA (cyclosporine A) ophthalmic gel suppresses T-cell activation and reduces inflammatory cytokine production in the eye to treat dry eye disease.
• Cyclosporine ophthalmic gel vehicle · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• Tacrolimus BID · Rabin Medical Center · Immunology
  Tacrolimus is an immunosuppressive drug that works by inhibiting calcineurin, which is necessary for the activation of T-lymphocytes.
• FK506MR · Astellas Pharma Inc · Immunology
  FK506MR is a modified-release formulation of tacrolimus that suppresses T-cell activation by inhibiting calcineurin phosphatase.
• Cyclosporine (CsA) · Assistance Publique - Hôpitaux de Paris · Immunology
  Cyclosporine inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.
• Elidel® (pimecrolimus) Cream · Glenmark Pharmaceuticals Ltd. India · Dermatology/Immunology
  Pimecrolimus is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.
• Cyclosporine Pill · Peking Union Medical College Hospital · Immunology
  Cyclosporine inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.
• CyclASol Ophthalmic Solution · Novaliq GmbH · Ophthalmology
  CyclASol is a cyclosporine A ophthalmic emulsion that suppresses local immune responses in the eye to reduce inflammation and improve tear production in dry eye disease.
• Injection of Cyclosporin · Hospices Civils de Lyon · Immunology
  Cyclosporin is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• IDP 121 Lotion · Bausch Health Americas, Inc. · Dermatology
  IDP 121 is a topical lotion formulation designed to treat inflammatory skin conditions by reducing inflammation and modulating immune response in the skin.
• Protopic® ointment, 0.1% · Glenmark Pharmaceuticals Ltd. India · Dermatology
  Protopic ointment, 0.1% works by inhibiting the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) to reduce inflammation.
• Restasis eye drop · Huons Co., Ltd. · Ophthalmology
  Restasis (cyclosporine) suppresses T-cell activation and reduces inflammatory cytokine production in the lacrimal glands and ocular surface to increase tear production.
• TAC-PF · National Eye Institute (NEI) · Ophthalmology
  TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye.
• Topical tacrolimus or pimecrolimus · Sanofi · Immunology
  Topical tacrolimus and pimecrolimus are calcineurin inhibitors that suppress the immune system by blocking the activation of T-lymphocytes.
• Calcineurin inhibitor therapy · Andrew B Adams · Immunology
  Calcineurin inhibitors suppress T-cell activation by blocking the phosphatase calcineurin, preventing the dephosphorylation and nuclear translocation of NFAT transcription factors required for cytokine production.
• Cyclosporine ophthalmic solution 0.05% · Taejoon Pharmaceutical Co., Ltd. · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• Cyclosporine 0.010% · Allergan · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• FKS518 · Fresenius Kabi SwissBioSim GmbH · Immunology
  FKS518 is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, thereby reducing immune-mediated rejection.
• Prograf-XL · Astellas Pharma Inc · Immunology
  Prograf-XL is an immunosuppressant that inhibits calcineurin.
• Topical calcineurin inhibitors · Sanofi · Immunology
  Topical calcineurin inhibitors block the action of calcineurin, a protein involved in the activation of T-cells, thereby reducing inflammation.

Phase 2 pipeline (9)

• CsA high dose · Fovea Pharmaceuticals SA · Immunology
  Calcineurin inhibitor
• Any topical drug treatment · LEO Pharma · Immunology
  Calcineurin inhibitor
• EnvarsusXR · Albert Einstein Healthcare Network · Oncology
  Calcineurin inhibitor
• Cyclosporin Capsules · Shanghai JMT-Bio Inc. · Immunology
  Cyclosporin Capsules inhibit calcineurin, preventing T-cell activation and proliferation.
• CD5024 0.3% cream · Galderma R&D · Dermatology
  CD5024 0.3% cream is a topical calcineurin inhibitor that suppresses the immune system by inhibiting T-cell activation.
• Cyclosporine 0.010% eye drops · Allergan · Immunology
  Cyclosporine is an immunosuppressant that inhibits calcineurin, thereby reducing T-cell activation.
• CsA low dose · Fovea Pharmaceuticals SA · Immunology
  CsA works by inhibiting calcineurin, a protein phosphatase involved in the activation of T-lymphocytes.
• CsA eye gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Ophthalmology
  Calcineurin inhibitor
• Cyclosporine NOVA22007 0.05% · Santen SAS · Ophthalmology
  Cyclosporine is an immunosuppressant that inhibits calcineurin, thereby reducing T-cell activation.

Patent intelligence

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