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Voclosporin（QL1074）

Qilu Pharmaceutical Co., Ltd. · Phase 3 active Small molecule

Voclosporin（QL1074） is a Calcineurin inhibitor Small molecule drug developed by Qilu Pharmaceutical Co., Ltd.. It is currently in Phase 3 development for Lupus nephritis.

Voclosporin is an immunosuppressant that inhibits calcineurin.

Voclosporin is an immunosuppressant that inhibits calcineurin. Used for Lupus nephritis.

At a glance

Generic nameVoclosporin（QL1074）
SponsorQilu Pharmaceutical Co., Ltd.
Drug classCalcineurin inhibitor
TargetCalcineurin
ModalitySmall molecule
Therapeutic areaImmunology
PhasePhase 3

Mechanism of action

Voclosporin works by binding to the immunophilin FKBP12, forming a complex that inhibits calcineurin, a phosphatase involved in the activation of T cells. This inhibition prevents the transcription of IL-2 and other cytokines, leading to immunosuppression.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Voclosporin（QL1074）

What is Voclosporin（QL1074）?

Voclosporin（QL1074） is a Calcineurin inhibitor drug developed by Qilu Pharmaceutical Co., Ltd., indicated for Lupus nephritis.

How does Voclosporin（QL1074） work?

Voclosporin is an immunosuppressant that inhibits calcineurin.

What is Voclosporin（QL1074） used for?

Voclosporin（QL1074） is indicated for Lupus nephritis.

Who makes Voclosporin（QL1074）?

Voclosporin（QL1074） is developed by Qilu Pharmaceutical Co., Ltd. (see full Qilu Pharmaceutical Co., Ltd. pipeline at /company/qilu-pharmaceutical-co-ltd).

What drug class is Voclosporin（QL1074） in?

Voclosporin（QL1074） belongs to the Calcineurin inhibitor class. See all Calcineurin inhibitor drugs at /class/calcineurin-inhibitor.

What development phase is Voclosporin（QL1074） in?

Voclosporin（QL1074） is in Phase 3.

What are the side effects of Voclosporin（QL1074）?

Common side effects of Voclosporin（QL1074） include Hypertension, Nausea, Headache, Diarrhea, Fatigue.

What does Voclosporin（QL1074） target?

Voclosporin（QL1074） targets Calcineurin and is a Calcineurin inhibitor.

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