Calcineurin — Drug Target

All drugs that target Calcineurin — marketed and clinical-stage. Includes 6 drug classes acting on this target.

Drug classes

Calcineurin inhibitor · Calcineurin inhibitor (topical immunosuppressant) · Calcineurin Inhibitor Immunosuppressant [EPC] · immunosuppressant · calcineurin inhibitor · Calcineurin inhibitor (ophthalmic)

Marketed (8)

• Cyclosporins/Tacrolimus · University of Minnesota · Calcineurin inhibitor · Immunology
  Cyclosporins and tacrolimus suppress the immune system by inhibiting calcineurin, a key enzyme required for T-cell activation and cytokine production.
• CycloSPORINE Ophthalmic · Université de Sherbrooke · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• topical pimecrolimus treatment · University Hospital, Ghent · Calcineurin inhibitor (topical immunosuppressant) · Dermatology/Immunology
  Pimecrolimus is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.
• Cyclosporine ophthalmic solution, 0.1% · Novaliq GmbH · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• CYCLOSPORINE · Calcineurin Inhibitor Immunosuppressant [EPC]
  Cyclosporine, a calcineurin inhibitor, selectively modulates the immune system.
• Cyclosporine 0.05% ophthalmic solution · Samsung Medical Center · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• cyclosporine micro-emulsion · Novartis · Calcineurin inhibitor · Immunology
  Cyclosporine micro-emulsion is an immunosuppressant that inhibits calcineurin, blocking T-cell activation and proliferation.
• Cyclosporine 0.05% · Ophthalmic Consultants of Long Island · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.

Phase 3 pipeline (24)

• Voclosporin（QL1074） · Qilu Pharmaceutical Co., Ltd. · Calcineurin inhibitor · Immunology
  Voclosporin is an immunosuppressant that inhibits calcineurin.
• cyclosporine ophthalmic emulsion · Vanderbilt-Ingram Cancer Center · immunosuppressant · Ophthalmology
  Cyclosporine ophthalmic emulsion works by suppressing the immune system to prevent rejection of transplanted corneal tissue.
• Cyclosporine ophthalmic solution 0.05% · Taejoon Pharmaceutical Co., Ltd. · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• Topical tacrolimus or pimecrolimus · Sanofi · calcineurin inhibitor · Immunology
  Topical tacrolimus and pimecrolimus are calcineurin inhibitors that suppress the immune system by blocking the activation of T-lymphocytes.
• LEO 80185 gel · LEO Pharma · Calcineurin inhibitor · Dermatology
  LEO 80185 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
• Topical calcineurin inhibitors · Sanofi · calcineurin inhibitor · Immunology
  Topical calcineurin inhibitors block the action of calcineurin, a protein involved in the activation of T-cells, thereby reducing inflammation.
• Tacrolimus BID · Rabin Medical Center · Calcineurin inhibitor · Immunology
  Tacrolimus is an immunosuppressive drug that works by inhibiting calcineurin, which is necessary for the activation of T-lymphocytes.
• tacrolimus + steroid · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan · immunosuppressant · Immunology
  Tacrolimus is an immunosuppressant that inhibits calcineurin, a protein phosphatase involved in the activation of T-lymphocytes, while steroids reduce inflammation and suppress the immune system.
• Cyclosporine ophthalmic gel vehicle · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• CsA-PG Ophthalmic Gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Calcineurin inhibitor · Ophthalmology
  CsA-PG is a cyclosporine A prodrug formulated as an ophthalmic gel that suppresses local immune responses in the eye to treat dry eye disease.
• CyclASol topical ocular, eye drops · Novaliq GmbH · Calcineurin inhibitor · Ophthalmology
  CyclASol is a cyclosporine A formulation in a novel aqueous nanomicellar vehicle designed to enhance corneal penetration and treat dry eye disease by suppressing ocular surface inflammation.
• Masked Ikervis · Santen SAS · Calcineurin inhibitor (ophthalmic) · Ophthalmology
  Ikervis is a cyclosporine A ophthalmic emulsion that suppresses local immune-mediated inflammation in the ocular surface.
• Placebo of Tacrolimus Ointment · Glenmark Pharmaceuticals Ltd. India · immunosuppressant · Immunology
  Tacrolimus ointment is an immunosuppressant that works by inhibiting calcineurin, a protein necessary for T-cell activation.
• Cyclosporine Vehicle · Allergan · Calcineurin inhibitor · Ophthalmology / Immunology
  Cyclosporine is an immunosuppressant that inhibits T-cell activation by blocking calcineurin, thereby reducing inflammatory responses in the eye.
• CyclASol Ophthalmic Solution · Novaliq GmbH · Calcineurin inhibitor · Ophthalmology
  CyclASol is a cyclosporine A ophthalmic emulsion that suppresses local immune responses in the eye to reduce inflammation and improve tear production in dry eye disease.
• Protopic® ointment, 0.1% · Glenmark Pharmaceuticals Ltd. India · calcineurin inhibitor · Dermatology
  Protopic ointment, 0.1% works by inhibiting the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) to reduce inflammation.
• Restasis (cyclosporine 0.05%) · DH Bio Co., Ltd. · immunosuppressant · Ophthalmology
  Restasis works by increasing tear production in patients with dry eye syndrome.
• Prograf-XL · Astellas Pharma Inc · Calcineurin inhibitor · Immunology
  Prograf-XL is an immunosuppressant that inhibits calcineurin.
• CsA Ophthalmic Gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Calcineurin inhibitor · Ophthalmology
  CsA (cyclosporine A) ophthalmic gel suppresses T-cell activation and reduces inflammatory cytokine production in the eye to treat dry eye disease.
• Cyclosporine 0.010% · Allergan · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.
• LEO 43204 gel · LEO Pharma · Calcineurin inhibitor · Dermatology
  LEO 43204 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
• IDP 121 Lotion · Bausch Health Americas, Inc. · Calcineurin inhibitor · Dermatology
  IDP 121 is a topical lotion formulation designed to treat inflammatory skin conditions by reducing inflammation and modulating immune response in the skin.
• TAC-PF · National Eye Institute (NEI) · Calcineurin inhibitor · Ophthalmology
  TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye.
• Tacrolimus modified-release · Hospital de Clinicas de Porto Alegre · Calcineurin inhibitor · Immunology
  Tacrolimus modified-release works by inhibiting calcineurin, which is involved in the activation of T-lymphocytes.

Phase 2 pipeline (9)

• Cyclosporin Capsules · Shanghai JMT-Bio Inc. · Calcineurin inhibitor · Immunology
  Cyclosporin Capsules inhibit calcineurin, preventing T-cell activation and proliferation.
• Any topical drug treatment · LEO Pharma · Calcineurin inhibitor · Immunology
  Calcineurin inhibitor
• CsA eye gel · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Calcineurin inhibitor · Ophthalmology
  Calcineurin inhibitor
• EnvarsusXR · Albert Einstein Healthcare Network · Calcineurin inhibitor · Oncology
  Calcineurin inhibitor
• CsA low dose · Fovea Pharmaceuticals SA · calcineurin inhibitor · Immunology
  CsA works by inhibiting calcineurin, a protein phosphatase involved in the activation of T-lymphocytes.
• CsA high dose · Fovea Pharmaceuticals SA · Calcineurin inhibitor · Immunology
  Calcineurin inhibitor
• Cyclosporine 0.010% eye drops · Allergan · Calcineurin inhibitor · Immunology
  Cyclosporine is an immunosuppressant that inhibits calcineurin, thereby reducing T-cell activation.
• CD5024 0.3% cream · Galderma R&D · calcineurin inhibitor · Dermatology
  CD5024 0.3% cream is a topical calcineurin inhibitor that suppresses the immune system by inhibiting T-cell activation.
• Cyclosporine NOVA22007 0.05% · Santen SAS · Calcineurin inhibitor · Ophthalmology
  Cyclosporine is an immunosuppressant that inhibits calcineurin, thereby reducing T-cell activation.