Immunosuppressant

This page covers all Immunosuppressant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Inosine monophosphate dehydrogenase (IMPDH) type II, calcineurin, inosine monophosphate dehydrogenase, calcineurin.

Targets

Inosine monophosphate dehydrogenase (IMPDH) type II · calcineurin, inosine monophosphate dehydrogenase · calcineurin · Inosine monophosphate dehydrogenase · Myeloperoxidase · Inosine monophosphate dehydrogenase (IMPDH) · inosine monophosphate dehydrogenase (IMPDH) · CD3 · NF-κB · mTOR

Marketed (3)

• Mycophenolic acid dose reduction · University of California, San Francisco · Immunology
  Mycophenolic acid dose reduction involves lowering the administered dose of mycophenolic acid, an immunosuppressant that inhibits inosine monophosphate dehydrogenase (IMPDH) to reduce T and B lymphocyte proliferation.
• MydCombi Drug · University of California, San Francisco · Immunology
  MydCombi Drug is a combination of mycophenolate mofetil and cyclosporine, which works by suppressing the immune system to prevent organ rejection.
• ISTp-DP · Kenya Medical Research Institute · Immunology
  ISTp-DP is a drug that targets the immune system to treat various conditions.

Phase 3 pipeline (17)

• cyclosporin + mycophenolate mofetil · Centre Hospitalier Universitaire, Amiens · Immunology
  Cyclosporin is an immunosuppressant that inhibits calcineurin, while mycophenolate mofetil is an inhibitor of inosine monophosphate dehydrogenase, both of which are involved in the activation of T cells.
• cyclosporine ophthalmic emulsion · Vanderbilt-Ingram Cancer Center · Ophthalmology
  Cyclosporine ophthalmic emulsion works by suppressing the immune system to prevent rejection of transplanted corneal tissue.
• Triptolide Wilfordii · Peking Union Medical College Hospital · Immunology
  Triptolide Wilfordii is a diterpenoid epoxide derived from the Chinese herb Tripterygium wilfordii, which has anti-inflammatory and immunosuppressive properties.
• supportive and immunosuppressive therapy · RWTH Aachen University · Immunology
  Supportive and immunosuppressive therapy involves the use of medications to suppress the immune system and prevent rejection in organ transplant patients, while also providing supportive care to manage symptoms and improve quality of life.
• Pre-emptive mycophenolate · University of Bologna · Immunology
  Mycophenolate works by inhibiting inosine monophosphate dehydrogenase, an enzyme crucial for the synthesis of guanosine nucleotides, thereby suppressing lymphocyte proliferation.
• AZA capsules · Centre Hospitalier Universitaire, Amiens · Immunology
  AZA capsules work by inhibiting the enzyme myeloperoxidase, which is involved in the production of reactive oxygen species.
• mycophenolate mofetil or azathioprine · Assistance Publique Hopitaux De Marseille · Immunology
  Mycophenolate mofetil and azathioprine are immunosuppressive drugs that inhibit the enzyme inosine monophosphate dehydrogenase (IMPDH), which is necessary for the proliferation of T and B lymphocytes.
• acid mycophenolic (Myfortic) · Assistance Publique - Hôpitaux de Paris · Immunology
  Acid mycophenolic inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine nucleotides.
• anti-thymocyte globulin (ATG) · Memorial Sloan Kettering Cancer Center · Immunology
  Anti-thymocyte globulin (ATG) works by binding to and depleting T-lymphocytes, which are a type of immune cell.
• tacrolimus + steroid · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan · Immunology
  Tacrolimus is an immunosuppressant that inhibits calcineurin, a protein phosphatase involved in the activation of T-lymphocytes, while steroids reduce inflammation and suppress the immune system.
• Thymoglobulin + Everolimus · University Hospital, Brest · Immunology
  Thymoglobulin is an anti-CD3 monoclonal antibody that depletes T cells, while Everolimus is an mTOR inhibitor that suppresses cell proliferation.
• Triptolide-Containing Formulation · Shanghai Changzheng Hospital · Immunology
  Triptolide-containing formulations exert their effects by inhibiting the transcription factor NF-κB, leading to anti-inflammatory and immunosuppressive effects.
• QTORIN 3.9% rapamycin anhydrous gel · Palvella Therapeutics, Inc. · Dermatology
  QTORIN 3.9% rapamycin anhydrous gel is a topical immunomodulator that targets the mTOR pathway.
• antilymphocyte serum · National Heart, Lung, and Blood Institute (NHLBI) · Immunology
  Antilymphocyte serum works by suppressing the immune system to prevent organ rejection in transplant patients.
• Placebo of Tacrolimus Ointment · Glenmark Pharmaceuticals Ltd. India · Immunology
  Tacrolimus ointment is an immunosuppressant that works by inhibiting calcineurin, a protein necessary for T-cell activation.
• azathioprine of 150 [75; 150] mg per day · I.M. Sechenov First Moscow State Medical University · Immunology
  Azathioprine is an immunosuppressive medication that works by inhibiting the synthesis of purine nucleotides, thereby suppressing the proliferation of T and B lymphocytes.
• Restasis (cyclosporine 0.05%) · DH Bio Co., Ltd. · Ophthalmology
  Restasis works by increasing tear production in patients with dry eye syndrome.

Phase 2 pipeline (5)

• ATG-LDPTCy · Samsung Medical Center · Immunology
  ATG-LDPTCy is an immunosuppressive agent that targets the T-cell receptor.
• AN2728 Topical Ointment, 2% QD · Pfizer · Dermatology
  AN2728 Topical Ointment, 2% QD is a topical ointment that targets the skin's immune response.
• MMF Immunosuppression · Wondercel Biotech (ShenZhen) · Immunology
  Inhibits inosine monophosphate dehydrogenase (IMPDH)
• ATG Thymoglobulin · St. Anna Kinderkrebsforschung · Oncology
  T-cell depleting agent
• Ciclosprin A · Hospices Civils de Lyon · Immunology
  Ciclosprin A is an immunosuppressive agent that inhibits the activity of T cells.