Last reviewed 2026-04-23 · How we verify

AN2728 Topical Ointment, 2% QD

Pfizer · Phase 2 active Small molecule

AN2728 Topical Ointment, 2% QD is a immunosuppressant Small molecule drug developed by Pfizer. It is currently in Phase 2 development for Moderate to severe plaque psoriasis.

AN2728 Topical Ointment, 2% QD is a topical ointment that targets the skin's immune response.

AN2728 Topical Ointment, 2% QD is a topical ointment that targets the skin's immune response. Used for Moderate to severe plaque psoriasis.

At a glance

Generic name	AN2728 Topical Ointment, 2% QD
Sponsor	Pfizer
Drug class	immunosuppressant
Modality	Small molecule
Therapeutic area	Dermatology
Phase	Phase 2

Mechanism of action

AN2728 works by modulating the immune response in the skin, reducing inflammation and potentially treating conditions such as psoriasis. The exact mechanism is not fully understood, but it is thought to involve the inhibition of certain immune cells in the skin.

Approved indications

Moderate to severe plaque psoriasis

Common side effects

Application site reactions
Headache
Nausea

Key clinical trials

Efficacy and Safety of AN2728 Topical Ointment to Treat Adolescents With Atopic Dermatitis (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

AN2728 Topical Ointment, 2% QD CI brief — competitive landscape report
AN2728 Topical Ointment, 2% QD updates RSS · CI watch RSS
Pfizer portfolio CI

Frequently asked questions about AN2728 Topical Ointment, 2% QD

What is AN2728 Topical Ointment, 2% QD?

AN2728 Topical Ointment, 2% QD is a immunosuppressant drug developed by Pfizer, indicated for Moderate to severe plaque psoriasis.

How does AN2728 Topical Ointment, 2% QD work?

AN2728 Topical Ointment, 2% QD is a topical ointment that targets the skin's immune response.

What is AN2728 Topical Ointment, 2% QD used for?

AN2728 Topical Ointment, 2% QD is indicated for Moderate to severe plaque psoriasis.

Who makes AN2728 Topical Ointment, 2% QD?

AN2728 Topical Ointment, 2% QD is developed by Pfizer (see full Pfizer pipeline at /company/pfizer).

What drug class is AN2728 Topical Ointment, 2% QD in?

AN2728 Topical Ointment, 2% QD belongs to the immunosuppressant class. See all immunosuppressant drugs at /class/immunosuppressant.

What development phase is AN2728 Topical Ointment, 2% QD in?

AN2728 Topical Ointment, 2% QD is in Phase 2.

What are the side effects of AN2728 Topical Ointment, 2% QD?

Common side effects of AN2728 Topical Ointment, 2% QD include Application site reactions, Headache, Nausea.

Drug class: All immunosuppressant drugs
Manufacturer: Pfizer — full pipeline
Therapeutic area: All drugs in Dermatology
Indication: Drugs for Moderate to severe plaque psoriasis
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