CD3 — Drug Target

All drugs that target CD3 — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Immunosuppressant · T-cell engager · Anti-CD3 monoclonal antibody

Phase 3 pipeline (2)

• anti-thymocyte globulin (ATG) · Memorial Sloan Kettering Cancer Center · Immunosuppressant · Immunology
  Anti-thymocyte globulin (ATG) works by binding to and depleting T-lymphocytes, which are a type of immune cell.
• Thymoglobulin + Everolimus · University Hospital, Brest · Immunosuppressant · Immunology
  Thymoglobulin is an anti-CD3 monoclonal antibody that depletes T cells, while Everolimus is an mTOR inhibitor that suppresses cell proliferation.

Phase 2 pipeline (2)

• CAN-2409 · Candel Therapeutics, Inc. · T-cell engager · Oncology
  CAN-2409 is a T-cell engager that targets the CD3 component of the T-cell receptor.
• Foralumab Nasal · Tiziana Life Sciences LTD · Anti-CD3 monoclonal antibody · Autoimmune diseases
  Foralumab Nasal is an anti-CD3 monoclonal antibody that modulates the immune system.