What drugs target mTOR?

6+ drugs target mTOR, including SIROLIMUS.

What drug classes act on mTOR?

Drug classes acting on mTOR include mTOR Inhibitor Immunosuppressant [EPC], mTOR inhibitor, immunosuppressant, SERD.

6 drugs 1 marketed 4 in Phase 3

All drugs that target mTOR — marketed and clinical-stage. Includes 4 drug classes acting on this target.

SIROLIMUS · mTOR Inhibitor Immunosuppressant [EPC]
Sirolimus binds to FKBP-12 to form a complex that inhibits mTOR, blocking T-cell proliferation and antibody production.

Rapamycin-calcitriol combination · National Taiwan University Hospital · mTOR inhibitor · Oncology
Rapamycin-calcitriol combination inhibits the mammalian target of rapamycin (mTOR) and vitamin D receptor (VDR) pathways.
LAM group · GlaxoSmithKline · mTOR inhibitor · Rare Pulmonary/Oncology
LAM group refers to a class of compounds targeting lymphangioleiomyomatosis-related pathways, likely inhibiting mTOR signaling to reduce abnormal smooth muscle cell proliferation.
QTORIN 3.9% rapamycin anhydrous gel · Palvella Therapeutics, Inc. · immunosuppressant · Dermatology
QTORIN 3.9% rapamycin anhydrous gel is a topical immunomodulator that targets the mTOR pathway.
Temsirolimus (CCI-779) · Pfizer · mTOR inhibitor · Oncology
Temsirolimus is a mTOR inhibitor that blocks the mTOR pathway, which is involved in cell growth and proliferation.