Last reviewed 2026-04-23 · How we verify

TAC-PF

TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye.

TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye. Used for Dry eye disease, Vernal keratoconjunctivitis, Ocular graft-versus-host disease.

At a glance

Mechanism of action

Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production. The PF (preservative-free) formulation allows for improved tolerability and reduced ocular surface irritation while maintaining the drug's immunomodulatory effects in treating inflammatory eye conditions.

Approved indications

• Dry eye disease
• Vernal keratoconjunctivitis
• Ocular graft-versus-host disease

Common side effects

• Ocular irritation
• Eye discomfort
• Conjunctival hyperemia

Key clinical trials

• One Cause of Heel Pain is Plantar Fasciopathy (PF). In Most Cases, a Heel Spur is Frequently Present Alongside PF. We Aim to Evaluate the Efficacy of Corticosteroid Injection and Radiofrequency Ablation, Along With Tissue Elasticity Assessed by Ultrasound, in Patients With Chronic Pain (≥6 Months). (NA)
• Glasdegib-Based Treatment Combinations for the Treatment of Patients With Relapsed Acute Myeloid Leukemia Who Have Undergone Hematopoietic Cell Transplantation (PHASE1)
• Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration (PHASE3)
• Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders (PHASE1)
• TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration (PHASE2)

Primary sources

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