{"id":"tac-pf","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Eye discomfort"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":{"chemblId":"CHEMBL455234","moleculeType":"Small molecule","molecularWeight":"276.26"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production. The PF (preservative-free) formulation allows for improved tolerability and reduced ocular surface irritation while maintaining the drug's immunomodulatory effects in treating inflammatory eye conditions.","oneSentence":"TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:37:13.188Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease"},{"name":"Vernal keratoconjunctivitis"},{"name":"Ocular graft-versus-host disease"}]},"trialDetails":[{"nctId":"NCT07120204","phase":"NA","title":"One Cause of Heel Pain is Plantar Fasciopathy (PF). In Most Cases, a Heel Spur is Frequently Present Alongside PF. We Aim to Evaluate the Efficacy of Corticosteroid Injection and Radiofrequency Ablation, Along With Tissue Elasticity Assessed by Ultrasound, in Patients With Chronic Pain (≥6 Months).","status":"NOT_YET_RECRUITING","sponsor":"TC Erciyes University","startDate":"2025-08-15","conditions":"Plantar Fasciopathy, Chronic Pain, Corticosteroid Injection","enrollment":50},{"nctId":"NCT04655391","phase":"PHASE1","title":"Glasdegib-Based Treatment Combinations for the Treatment of Patients With Relapsed Acute Myeloid Leukemia Who Have Undergone Hematopoietic Cell Transplantation","status":"WITHDRAWN","sponsor":"City of Hope Medical Center","startDate":"2022-06-25","conditions":"Recurrent Acute Myeloid Leukemia","enrollment":""},{"nctId":"NCT00100009","phase":"PHASE3","title":"Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2004-12-09","conditions":"Macular Degeneration","enrollment":30},{"nctId":"NCT00071227","phase":"PHASE1","title":"Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2003-10-15","conditions":"Macular Degeneration, Retinal Vein Occlusion","enrollment":16},{"nctId":"NCT00464347","phase":"PHASE2","title":"TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration","status":"TERMINATED","sponsor":"National Eye Institute (NEI)","startDate":"2007-01","conditions":"Age-Related Macular Degeneration","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"TAC-PF","genericName":"TAC-PF","companyName":"National Eye Institute (NEI)","companyId":"national-eye-institute-nei","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TAC-PF is a topical formulation designed to deliver tacrolimus to ocular tissues for immunosuppressive and anti-inflammatory effects in the eye. Used for Dry eye disease, Vernal keratoconjunctivitis, Ocular graft-versus-host disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}