Calcium channel blocker + Angiotensin II receptor blocker combination

This page covers all Calcium channel blocker + Angiotensin II receptor blocker combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting L-type voltage-gated calcium channels; AT1 angiotensin II receptor, AT1 receptor (angiotensin II type 1 receptor), AT1 receptor / L-type calcium channel.

Targets

L-type voltage-gated calcium channels; AT1 angiotensin II receptor · AT1 receptor (angiotensin II type 1 receptor) · AT1 receptor / L-type calcium channel · Angiotensin-converting enzyme (ACE) and Angiotensin II type 1 receptor (AT1R) · ACE enzyme and AT1 angiotensin II receptor · ACE enzyme or Angiotensin II Type 1 receptor (AT1R) · AT1 receptor (Angiotensin II type 1 receptor) · AT1 receptor (losartan); L-type voltage-gated calcium channel (amlodipine) · AT1 receptor (angiotensin II type 1) / Beta-1 adrenergic receptor · Angiotensin II receptors (AT1) and L-type calcium channels

Marketed (57)

• Felodipine add Irbesartan · LanZhou University · Cardiovascular
  This combination reduces blood pressure by blocking calcium channels (felodipine) to relax blood vessels and blocking angiotensin II receptors (irbesartan) to reduce vasoconstriction and aldosterone release.
• losartan (drug) · Odense University Hospital · Cardiovascular
  Losartan blocks angiotensin II receptors on blood vessels and tissues, preventing vasoconstriction and reducing blood pressure.
• valsartan/amlodpine · University of Pavia · Cardiovascular
  Valsartan/amlodipine is a combination of an angiotensin II receptor blocker and a calcium channel blocker that reduces blood pressure through dual vasodilation and reduced vasoconstriction.
• Quinapril + Losartan · AHEPA University Hospital · Cardiovascular
  This combination blocks two different pathways in the renin-angiotensin-aldosterone system (RAAS) to lower blood pressure: quinapril inhibits ACE while losartan blocks angiotensin II receptors.
• Ramipril + Irbesartan · Bristol-Myers Squibb · Cardiovascular
  This combination lowers blood pressure by blocking angiotensin II through two complementary pathways: ACE inhibition and angiotensin II receptor antagonism.
• RAS Inhibitors · Shenzhen Second People's Hospital · Cardiovascular
  RAS inhibitors block the renin-angiotensin system to reduce blood pressure and protect organs from hypertension-related damage.
• Placebo to Telmisartan · Novartis · Cardiovascular
  Telmisartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• Losartan (+) amlodipine · Organon and Co · Cardiovascular
  This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.
• valsartan/atenolol · Novartis · Cardiovascular
  This combination drug lowers blood pressure by blocking angiotensin II receptors (valsartan) and beta-adrenergic receptors (atenolol) to reduce vasoconstriction and heart rate.
• losartan/amlodpine · University of Pavia · Cardiovascular
• Telmisartan + Amlodipine · Daewon Pharmaceutical Co., Ltd. · Cardiovascular
  Telmisartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload.
• Cozaar · Merck & Co. · Metabolic
  Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 receptor.
• Valsartan (Diovan) · Radboud University Medical Center · Cardiovascular
  Valsartan blocks angiotensin II receptors on blood vessels and the heart, causing vasodilation and reducing blood pressure.
• olmesartan medoxomil / amlodipine or azelnidipine · COLM Study Research Organization · Cardiovascular
  This combination lowers blood pressure by blocking angiotensin II receptors (olmesartan medoxomil) and calcium channels (amlodipine or azelnidipine) to relax blood vessels.
• Candesartan/HCT · Population Health Research Institute · Cardiovascular
  Candesartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide acts as a diuretic to reduce fluid volume.
• Candesartan cilexetil/Amlodipine besylate · HK inno.N Corporation · Cardiovascular
  This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.
• olmesartan medoxomil+probenecid · Central South University · Cardiovascular; Rheumatology
  Olmesartan medoxomil blocks angiotensin II receptors to lower blood pressure, while probenecid inhibits uric acid reabsorption in the kidney to reduce serum uric acid levels.
• Olmesartan/amlodipine · Institut für Pharmakologie und Präventive Medizin · Cardiovascular
  Olmesartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload.
• placebo/valsartan · Medical University of Silesia · Cardiovascular
  Valsartan blocks angiotensin II type 1 receptors, reducing vasoconstriction and aldosterone secretion to lower blood pressure.
• Irbesartan (Aprovel) · Sanofi · Cardiovascular
  Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Irbesartan Oral Tablet · University of Southern Denmark · Cardiovascular
  Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Micardis plus 80/12.5 · Heart Care Foundation · Cardiovascular
  Micardis Plus combines telmisartan (an angiotensin II receptor blocker) with hydrochlorothiazide (a thiazide diuretic) to lower blood pressure through dual mechanisms of vasodilation and sodium/fluid reduction.
• Cozzar tablet · Chong Kun Dang Pharmaceutical · Cardiovascular
  Cozzar (losartan) blocks angiotensin II receptors to relax blood vessels and lower blood pressure.
• olmesartan medoxomil and a CCB · Daiichi Sankyo Co., Ltd. · Cardiovascular
  This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through dual vasodilation and reduced vascular resistance.
• Olmesartan medoxomil tablets · Lee's Pharmaceutical Limited · Cardiovascular
  Olmesartan medoxomil blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• Amlodipine/Olmesartan · Radboud University Medical Center · Cardiovascular
  Amlodipine relaxes blood vessels by blocking calcium channels, while olmesartan blocks angiotensin II receptors to reduce vasoconstriction and lower blood pressure.
• Olmesartan medoxomil tablets low dose · Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company · Cardiovascular
  Olmesartan medoxomil blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• potassium losartan · Fifth Affiliated Hospital, Sun Yat-Sen University · Cardiovascular
  Losartan blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Renin-angiotensin system blockers · Hospital Authority, Hong Kong · Cardiovascular
  Renin-angiotensin system blockers inhibit the formation or action of angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure and decreasing cardiac workload.
• Candesartan Thiazide · Institut de Recherches Cliniques de Montreal · Cardiovascular
  Candesartan thiazide is a combination drug that blocks angiotensin II receptors to lower blood pressure while a thiazide diuretic enhances sodium and water excretion.
• Candemore Plus Tab · Chong Kun Dang Pharmaceutical · Cardiovascular
  Candemore Plus is a fixed-dose combination of candesartan cilexetil (an angiotensin II receptor blocker) and amlodipine (a calcium channel blocker) that reduces blood pressure through dual vasodilation and renin-angiotensin system inhibition.
• Amosartan® tab · Hanmi Pharmaceutical Company Limited · Cardiovascular
  Amosartan is an angiotensin II receptor blocker (ARB) that selectively antagonizes the AT1 receptor to reduce vasoconstriction and lower blood pressure.
• Cozaar® · Teva Pharmaceuticals USA · Cardiovascular
  Cozaar blocks angiotensin II receptors on blood vessels and tissues, causing vasodilation and reducing blood pressure.
• irbesartan and irbesartan-hydrochlorothiazide · Sanofi · Cardiovascular
  Irbesartan blocks angiotensin II type 1 receptors to relax blood vessels and lower blood pressure; the combination formulation adds hydrochlorothiazide, a thiazide diuretic that reduces fluid volume.
• Candemore tablet · Chong Kun Dang Pharmaceutical · Cardiovascular
  Candemore is an angiotensin II receptor blocker (ARB) that selectively blocks AT1 receptors to reduce vasoconstriction and lower blood pressure.
• Valsartan (-based therapy) arm · Hippocration General Hospital · Cardiovascular
  Valsartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• pravastatin, valsartan, pravastatin+valsartan · Gachon University Gil Medical Center · Cardiovascular
  Pravastatin inhibits HMG-CoA reductase to lower cholesterol, while valsartan blocks angiotensin II receptors to reduce blood pressure; the combination addresses both lipid and hypertension management.
• Aliskiren + Valsartan · HeartDrug Research LLC · Cardiovascular
  Aliskiren and valsartan work together to lower blood pressure by blocking the renin-angiotensin-aldosterone system at two different points: aliskiren directly inhibits renin, while valsartan blocks angiotensin II receptors.
• Nifedipine/Telmisartan · Bayer · Cardiovascular
  This combination reduces blood pressure by blocking calcium channels (nifedipine) to relax blood vessels and blocking angiotensin II receptors (telmisartan) to prevent vasoconstriction.
• Losartan/amlodipine or losartan/hydrochlorothiazide · Yokohama City University Medical Center · Cardiovascular
  This is a fixed-dose combination of losartan (an angiotensin II receptor blocker) with either amlodipine (a calcium channel blocker) or hydrochlorothiazide (a thiazide diuretic) to lower blood pressure through multiple complementary pathways.

Phase 3 pipeline (43)

• Fimasartan and Amlodipine · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan blocks angiotensin II receptors to lower blood pressure, while amlodipine relaxes blood vessels by blocking calcium channels, providing dual antihypertensive action.
• Azilsartan medoxomil and chlorthalidone · Takeda · Cardiovascular
  Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while chlorthalidone is a thiazide-like diuretic that reduces fluid volume and sodium reabsorption.
• Benazepril/Valsartan · Mario Negri Institute for Pharmacological Research · Cardiovascular
  Benazepril/Valsartan is a combination of an ACE inhibitor and an angiotensin II receptor blocker that reduces blood pressure by inhibiting two complementary pathways of the renin-angiotensin-aldosterone system.
• Fimasartan + Indapamide · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan blocks angiotensin II receptors to lower blood pressure, while indapamide acts as a thiazide-like diuretic to reduce fluid volume and further decrease blood pressure.
• Irbesartan monotherapy · Bristol-Myers Squibb · Cardiovascular
  Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• TAK-536CCB · Takeda · Cardiovascular
  TAK-536CCB is a dual angiotensin II receptor blocker and calcium channel blocker combination designed to lower blood pressure through multiple mechanisms.
• Irbesartan/Amlodipine · Handok Inc. · Cardiovascular
  This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.
• Atacand/HCT, Caduet · Baim Institute for Clinical Research · Cardiovascular
  Atacand/HCT combines an angiotensin II receptor blocker with a thiazide diuretic to reduce blood pressure through vasodilation and sodium/fluid excretion, while Caduet combines an HMG-CoA reductase inhibitor with a calcium channel blocker to lower cholesterol and blood pressure.
• Candesartan+HCTZ - Phase 1 · Novartis · Cardiovascular
  Candesartan blocks angiotensin II receptors to lower blood pressure, while HCTZ is a thiazide diuretic that reduces fluid volume and sodium reabsorption.
• Fimasartan or Fimasartan/Hydrochlorothiazide · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan is an angiotensin II receptor blocker (ARB) that selectively antagonizes the AT1 receptor to reduce vasoconstriction and lower blood pressure.
• ARB + DMX-200 · UMC Utrecht · Cardiovascular
  ARB + DMX-200 combines an angiotensin II receptor blocker with DMX-200, a drug delivery technology designed to enhance therapeutic efficacy and potentially reduce adverse effects.
• Fimasartan and Rosuvastatin · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan blocks angiotensin II receptors to lower blood pressure, while rosuvastatin inhibits HMG-CoA reductase to reduce cholesterol synthesis.
• Azilsartan Medoxomil and amlodipine · Takeda · Cardiovascular
  Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload.
• Irbesartan treatment · Steno Diabetes Center Copenhagen · Cardiovascular
  Irbesartan blocks angiotensin II type 1 receptors, reducing vasoconstriction and aldosterone secretion to lower blood pressure.
• Azilsartan medoxomil - chlorthalidone · Takeda · Cardiovascular
  Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while chlorthalidone is a thiazide-like diuretic that reduces fluid volume and sodium reabsorption.
• Azilsartan medoxomil and olmesartan · Takeda · Cardiovascular
  This combination of two angiotensin II receptor blockers (ARBs) blocks the angiotensin II type 1 receptor to reduce blood pressure and provide cardiovascular protection.
• Valsartan + Amlodipine besilate · Novartis · Cardiovascular
  Valsartan blocks angiotensin II receptors to lower blood pressure, while amlodipine relaxes blood vessels by blocking calcium channels, providing dual antihypertensive action.
• Comparator: placebo, losartan, hydrochlorothiazide · Organon and Co · Cardiovascular
  This drug is an angiotensin II receptor blocker (ARB) that lowers blood pressure by blocking the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release.
• Irbesartan/HCTZ · Bristol-Myers Squibb · Cardiovascular
  Irbesartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to reduce fluid volume.
• AT1 blocker candesartan · The Netherlands Cancer Institute · Oncology
  Candesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• Allisartan Isoproxil/Sustained-Release Indapamide · Shenzhen Salubris Pharmaceuticals Co., Ltd. · Cardiovascular
  This combination drug lowers blood pressure by blocking angiotensin II receptors (allisartan isoproxil) and inhibiting sodium reabsorption in the kidney (sustained-release indapamide).
• Amlodipine plus Losartan · Hanmi Pharmaceutical Company Limited · Cardiovascular
  Amlodipine and losartan work together to lower blood pressure by relaxing blood vessels through calcium channel blockade and angiotensin II receptor antagonism.
• Irbesartan/Atorvastatin A · Hanmi Pharmaceutical Company Limited · Cardiovascular
  Irbesartan/Atorvastatin is a fixed-dose combination that lowers blood pressure via angiotensin II receptor blockade and reduces cholesterol via HMG-CoA reductase inhibition.
• AGT4, AGZ · Ahn-Gook Pharmaceuticals Co.,Ltd · Cardiovascular
  AGT4 and AGZ are angiotensin II receptor blockers.
• Comparator: Losartan · Merck Sharp & Dohme LLC · Cardiovascular
  Losartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• AZM X mg + AML Y mg · Celltrion · Cardiovascular
  AZM (azilsartan) is an angiotensin II receptor blocker and AML (amlodipine) is a calcium channel blocker; together they reduce blood pressure through complementary vasodilatory pathways.
• Telmisartan, Ramipril · Post Graduate Institute of Medical Education and Research, Chandigarh · Cardiovascular
  This combination blocks angiotensin II signaling through two complementary pathways: telmisartan blocks the angiotensin II type 1 receptor, while ramipril inhibits ACE to prevent angiotensin II formation.
• Fimasartan/HCTZ combination · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan blocks angiotensin II type 1 receptors to lower blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to reduce fluid volume and further decrease blood pressure.
• Angiotensin II Receptor Blockers · Ottawa Heart Institute Research Corporation · Cardiovascular
  Angiotensin II Receptor Blockers (ARBs) block the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Active comparator2 : Telmisartan · Hanlim Pharm. Co., Ltd. · Cardiovascular
  Telmisartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• Irbesartan/Amlodipine high · Handok Inc. · Cardiovascular
  This combination drug blocks angiotensin II receptors and calcium channels to reduce blood pressure through dual vasodilation and reduced vascular resistance.
• Azilsartan medoxomil and hydrochlorothiazide · Takeda · Cardiovascular
  Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume.
• Candesartan plus Hydrochlorothiazide · Novartis · Cardiovascular
  Candesartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume and sodium reabsorption.
• Azilsartan tablets · Lee's Pharmaceutical Limited · Cardiovascular
  Azilsartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing blood pressure.
• Azilsartan Medoxomil Low-dose · Arbor Pharmaceuticals, Inc. · Cardiovascular
  Azilsartan medoxomil is an angiotensin II receptor blocker (ARB) that selectively blocks AT1 receptors to reduce blood pressure.
• Losartan (Control) · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Losartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.
• Amlodipine, losartan potassium and hydrochlorothiazide · Shanghai WiseGain Medical Devices Co., Ltd. · Cardiovascular
  This triple-combination antihypertensive reduces blood pressure through three complementary mechanisms: calcium channel blockade, angiotensin II receptor antagonism, and thiazide diuresis.
• Fimasartan; Hydrochlorothiazide · Stendhal Americas, S.A. · Cardiovascular
  Fimasartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume and sodium reabsorption.
• Fimasartan, Rosuvastatin · Boryung Pharmaceutical Co., Ltd · Cardiovascular
  Fimasartan is an angiotensin II receptor blocker that reduces blood pressure, while rosuvastatin is a statin that lowers cholesterol; together they address hypertension and dyslipidemia.
• Comparator: losartan +/- HCTZ · Organon and Co · Cardiovascular
  Losartan is an angiotensin II receptor antagonist that blocks vasoconstriction and aldosterone secretion to lower blood pressure; HCTZ is a thiazide diuretic that reduces fluid volume.

Phase 2 pipeline (1)

• Anti-hypertensive drug treatment · Universidade Gama Filho · Cardiovascular
  Blocks the action of angiotensin II at its receptor

Patent intelligence

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