Last reviewed · How we verify
Candesartan cilexetil/Amlodipine besylate
Candesartan cilexetil/Amlodipine besylate is a Angiotensin II receptor blocker / Calcium channel blocker combination Small molecule drug developed by HK inno.N Corporation. It is currently FDA-approved for Hypertension (high blood pressure). Also known as: Candesartan cilexetil/Amlodipine besylate 8 mg/5 mg.
This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.
This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance. Used for Hypertension (high blood pressure).
At a glance
| Generic name | Candesartan cilexetil/Amlodipine besylate |
|---|---|
| Also known as | Candesartan cilexetil/Amlodipine besylate 8 mg/5 mg |
| Sponsor | HK inno.N Corporation |
| Drug class | Angiotensin II receptor blocker / Calcium channel blocker combination |
| Target | AT1 receptor (angiotensin II type 1 receptor) / L-type voltage-gated calcium channel |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Candesartan cilexetil is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to AT1 receptors, reducing vasoconstriction and aldosterone secretion. Amlodipine besylate is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation. Together, these complementary mechanisms provide additive blood pressure reduction.
Approved indications
- Hypertension (high blood pressure)
Common side effects
- Dizziness
- Headache
- Peripheral edema
- Fatigue
- Hyperkalemia (with ARB component)
Key clinical trials
- Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study
- Evaluate the Efficacy and Safety of SPC1001 Low in Patients With Essential Hypertension (PHASE2)
- Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension (PHASE3)
- To Evaluate the Efficacy and Safety of Co-administrated HODO-2224-1 and HODO-2224-2 in Patients With Essential Hypertension and Primary Hypercholesterolemia (PHASE3)
- Safety and Pharmacokinetics Study of amlodipine10mg and candesartan32mg (PHASE1)
- Bioequivalence Study (Candesartan 16 mg and Amlodipine 10 mg) (PHASE1)
- Efficacy and Safety of SPC1001 in Patients With Essential Hypertension (PHASE2)
- Efficacy and Safety of a Quadruple Ultra-low-dose Treatment for Hypertension (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Candesartan cilexetil/Amlodipine besylate CI brief — competitive landscape report
- Candesartan cilexetil/Amlodipine besylate updates RSS · CI watch RSS
- HK inno.N Corporation portfolio CI
Frequently asked questions about Candesartan cilexetil/Amlodipine besylate
What is Candesartan cilexetil/Amlodipine besylate?
How does Candesartan cilexetil/Amlodipine besylate work?
What is Candesartan cilexetil/Amlodipine besylate used for?
Who makes Candesartan cilexetil/Amlodipine besylate?
Is Candesartan cilexetil/Amlodipine besylate also known as anything else?
What drug class is Candesartan cilexetil/Amlodipine besylate in?
What development phase is Candesartan cilexetil/Amlodipine besylate in?
What are the side effects of Candesartan cilexetil/Amlodipine besylate?
What does Candesartan cilexetil/Amlodipine besylate target?
Related
- Drug class: All Angiotensin II receptor blocker / Calcium channel blocker combination drugs
- Target: All drugs targeting AT1 receptor (angiotensin II type 1 receptor) / L-type voltage-gated calcium channel
- Manufacturer: HK inno.N Corporation — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension (high blood pressure)
- Also known as: Candesartan cilexetil/Amlodipine besylate 8 mg/5 mg
- Compare: Candesartan cilexetil/Amlodipine besylate vs similar drugs
- Pricing: Candesartan cilexetil/Amlodipine besylate cost, discount & access