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Azilsartan medoxomil and hydrochlorothiazide
Azilsartan medoxomil and hydrochlorothiazide is a Angiotensin II receptor blocker (ARB) + thiazide diuretic combination Small molecule drug developed by Takeda. It is currently in Phase 3 development for Hypertension (high blood pressure). Also known as: TAK-491, TAK-491CLD.
Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume.
Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume. Used for Hypertension (high blood pressure).
At a glance
| Generic name | Azilsartan medoxomil and hydrochlorothiazide |
|---|---|
| Also known as | TAK-491, TAK-491CLD |
| Sponsor | Takeda |
| Drug class | Angiotensin II receptor blocker (ARB) + thiazide diuretic combination |
| Target | AT1 receptor (angiotensin II type 1 receptor); sodium-chloride cotransporter |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Azilsartan medoxomil is an angiotensin II receptor blocker (ARB) that selectively antagonizes AT1 receptors, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide is a thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubule, reducing blood volume and electrolyte levels. The combination provides complementary antihypertensive effects through different mechanisms.
Approved indications
- Hypertension (high blood pressure)
Common side effects
- Dizziness
- Fatigue
- Hyperkalemia (elevated potassium)
- Hypokalemia (low potassium)
- Hyperuricemia (elevated uric acid)
- Headache
Key clinical trials
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- Observational Study of Azilsartan/Chlorthalidone and Irbesartan/Hydrochlorothiazide in Hypertension and Obesity.
- Study to Evaluate the Efficacy and Safety of Combined Administration of TAK-536CCB and Hydrochlorothiazide in Patients With Grade I or II Essential Hypertension. (PHASE2, PHASE3)
- Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease (PHASE3)
- Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension. (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Azilsartan medoxomil and hydrochlorothiazide CI brief — competitive landscape report
- Azilsartan medoxomil and hydrochlorothiazide updates RSS · CI watch RSS
- Takeda portfolio CI
Frequently asked questions about Azilsartan medoxomil and hydrochlorothiazide
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Related
- Drug class: All Angiotensin II receptor blocker (ARB) + thiazide diuretic combination drugs
- Target: All drugs targeting AT1 receptor (angiotensin II type 1 receptor); sodium-chloride cotransporter
- Manufacturer: Takeda — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension (high blood pressure)
- Also known as: TAK-491, TAK-491CLD
- Compare: Azilsartan medoxomil and hydrochlorothiazide vs similar drugs
- Pricing: Azilsartan medoxomil and hydrochlorothiazide cost, discount & access