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Angiotensin II Receptor Blockers
Angiotensin II Receptor Blockers is a Angiotensin II Receptor Blocker (ARB) Small molecule drug developed by Ottawa Heart Institute Research Corporation. It is currently in Phase 3 development for Hypertension, Heart failure with reduced ejection fraction, Post-myocardial infarction cardioprotection. Also known as: azilsartan, candesartan, eprosartan, Irbesartan.
Angiotensin II Receptor Blockers (ARBs) block the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release to lower blood pressure.
Angiotensin II Receptor Blockers (ARBs) block the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release to lower blood pressure. Used for Hypertension, Heart failure with reduced ejection fraction, Post-myocardial infarction cardioprotection.
At a glance
| Generic name | Angiotensin II Receptor Blockers |
|---|---|
| Also known as | azilsartan, candesartan, eprosartan, Irbesartan, losartan |
| Sponsor | Ottawa Heart Institute Research Corporation |
| Drug class | Angiotensin II Receptor Blocker (ARB) |
| Target | AT1 receptor (Angiotensin II Type 1 Receptor) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
ARBs selectively antagonize AT1 receptors on vascular smooth muscle and adrenal tissue, inhibiting the renin-angiotensin-aldosterone system (RAAS). This prevents angiotensin II-mediated vasoconstriction, sodium retention, and sympathetic activation, resulting in vasodilation and reduced blood pressure. ARBs are commonly used for hypertension management and have cardioprotective effects in heart failure and post-myocardial infarction patients.
Approved indications
- Hypertension
- Heart failure with reduced ejection fraction
- Post-myocardial infarction cardioprotection
- Diabetic nephropathy
Common side effects
- Hyperkalemia
- Dizziness
- Fatigue
- Hypotension
- Cough (less common than with ACE inhibitors)
Key clinical trials
- Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES) (NA)
- Efficacy and Safety of Sacubitril/Valsartan in African American Patients With Heart Failure With Reduced Ejection Fraction
- A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease (PHASE1, PHASE2)
- Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection
- Study to Evaluate the Impact of Iptacopan on Top of SOC on Biopsy Changes in Kidneys of Adult Patients With IgAN (PHASE2)
- Safety and Tolerability of Subretinally Injected OPGx-BEST1 in Patients With Best Vitelliform Macular Dystrophy (BVMD) or Autosomal-Recessive Bestrophinopathy (ARB) (PHASE1, PHASE2)
- Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
- A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Angiotensin II Receptor Blockers CI brief — competitive landscape report
- Angiotensin II Receptor Blockers updates RSS · CI watch RSS
- Ottawa Heart Institute Research Corporation portfolio CI
Frequently asked questions about Angiotensin II Receptor Blockers
What is Angiotensin II Receptor Blockers?
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Related
- Drug class: All Angiotensin II Receptor Blocker (ARB) drugs
- Target: All drugs targeting AT1 receptor (Angiotensin II Type 1 Receptor)
- Manufacturer: Ottawa Heart Institute Research Corporation — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Indication: Drugs for Heart failure with reduced ejection fraction
- Indication: Drugs for Post-myocardial infarction cardioprotection
- Also known as: azilsartan, candesartan, eprosartan, Irbesartan, losartan
- Compare: Angiotensin II Receptor Blockers vs similar drugs
- Pricing: Angiotensin II Receptor Blockers cost, discount & access