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Azilsartan medoxomil and chlorthalidone
Azilsartan medoxomil and chlorthalidone is a Angiotensin II receptor blocker / Thiazide-like diuretic combination Small molecule drug developed by Takeda. It is currently in Phase 3 development for Hypertension. Also known as: TAK-491, TAK-491CLD, azilsartan medoxomil, chlorthalidone.
Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while chlorthalidone is a thiazide-like diuretic that reduces fluid volume and sodium reabsorption.
Azilsartan medoxomil blocks angiotensin II receptors to lower blood pressure, while chlorthalidone is a thiazide-like diuretic that reduces fluid volume and sodium reabsorption. Used for Hypertension.
At a glance
| Generic name | Azilsartan medoxomil and chlorthalidone |
|---|---|
| Also known as | TAK-491, TAK-491CLD, azilsartan medoxomil, chlorthalidone, Edarbi |
| Sponsor | Takeda |
| Drug class | Angiotensin II receptor blocker / Thiazide-like diuretic combination |
| Target | AT1 receptor (angiotensin II type 1 receptor) / Sodium-chloride cotransporter |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Azilsartan medoxomil is an angiotensin II receptor blocker (ARB) that selectively antagonizes AT1 receptors, preventing vasoconstriction and aldosterone secretion. Chlorthalidone is a long-acting thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, reducing blood volume and peripheral vascular resistance. The combination provides complementary antihypertensive effects through different mechanisms.
Approved indications
- Hypertension
Common side effects
- Dizziness
- Fatigue
- Hyperuricemia
- Hypokalemia
- Hyperglycemia
- Hypotension
Key clinical trials
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- Observational Study of Azilsartan/Chlorthalidone and Irbesartan/Hydrochlorothiazide in Hypertension and Obesity.
- A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone (PHASE3)
- Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease (PHASE3)
- Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension (PHASE3)
- Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Azilsartan medoxomil and chlorthalidone CI brief — competitive landscape report
- Azilsartan medoxomil and chlorthalidone updates RSS · CI watch RSS
- Takeda portfolio CI
Frequently asked questions about Azilsartan medoxomil and chlorthalidone
What is Azilsartan medoxomil and chlorthalidone?
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Related
- Drug class: All Angiotensin II receptor blocker / Thiazide-like diuretic combination drugs
- Target: All drugs targeting AT1 receptor (angiotensin II type 1 receptor) / Sodium-chloride cotransporter
- Manufacturer: Takeda — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Also known as: TAK-491, TAK-491CLD, azilsartan medoxomil, chlorthalidone, Edarbi
- Compare: Azilsartan medoxomil and chlorthalidone vs similar drugs
- Pricing: Azilsartan medoxomil and chlorthalidone cost, discount & access