Last reviewed 2026-04-22 · How we verify

Telmisartan + Amlodipine

Telmisartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload.

Telmisartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload. Used for Hypertension (essential hypertension).

At a glance

Mechanism of action

This is a fixed-dose combination of two antihypertensive agents with complementary mechanisms. Telmisartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone release, reducing blood pressure and afterload. Amlodipine is a dihydropyridine calcium channel blocker that causes vasodilation by inhibiting calcium influx into vascular smooth muscle cells. Together, they provide synergistic blood pressure reduction.

Approved indications

• Hypertension (essential hypertension)

Common side effects

• Dizziness
• Peripheral edema
• Headache
• Fatigue
• Hyperkalemia

Key clinical trials

• Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension (PHASE4)
• Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study
• Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (PHASE3)
• INTERVENCION Trial (PHASE4)
• Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension (PHASE3)
• Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension (PHASE3)
• Arterial Stiffness and Blood Pressure (NA)
• Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients with Essential Hypertension

Primary sources

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