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Losartan/amlodipine or losartan/hydrochlorothiazide
Losartan/amlodipine or losartan/hydrochlorothiazide is a Angiotensin II receptor blocker combination (ARB + calcium channel blocker or ARB + thiazide diuretic) Small molecule drug developed by Yokohama City University Medical Center. It is currently FDA-approved for Hypertension (high blood pressure). Also known as: Preminent (Hyzaar).
This is a fixed-dose combination of losartan (an angiotensin II receptor blocker) with either amlodipine (a calcium channel blocker) or hydrochlorothiazide (a thiazide diuretic) to lower blood pressure through multiple complementary pathways.
This is a fixed-dose combination of losartan (an angiotensin II receptor blocker) with either amlodipine (a calcium channel blocker) or hydrochlorothiazide (a thiazide diuretic) to lower blood pressure through multiple complementary pathways. Used for Hypertension (high blood pressure).
At a glance
| Generic name | Losartan/amlodipine or losartan/hydrochlorothiazide |
|---|---|
| Also known as | Preminent (Hyzaar) |
| Sponsor | Yokohama City University Medical Center |
| Drug class | Angiotensin II receptor blocker combination (ARB + calcium channel blocker or ARB + thiazide diuretic) |
| Target | Angiotensin II type 1 receptor (AT1R); L-type voltage-gated calcium channels (amlodipine) or sodium-chloride cotransporter (hydrochlorothiazide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Losartan blocks angiotensin II receptors, reducing vasoconstriction and aldosterone secretion. Amlodipine relaxes vascular smooth muscle by blocking L-type calcium channels, while hydrochlorothiazide reduces blood volume and sodium reabsorption. The combination provides additive antihypertensive effects and improved blood pressure control compared to monotherapy.
Approved indications
- Hypertension (high blood pressure)
Common side effects
- Dizziness
- Headache
- Fatigue
- Peripheral edema (amlodipine formulation)
- Hyperuricemia (hydrochlorothiazide formulation)
- Hyperkalemia
Key clinical trials
- N-of-1 Trials In Children With Hypertension (PHASE4)
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes (PHASE4)
- Coronavirus (COVID-19) ACEi/ARB Investigation (PHASE4)
- N-of-1 Trials for Blood Pressure Medications in Adults (EARLY_PHASE1)
- Fixed-Free HTN Trial (PHASE4)
- Comparision of Blood Pressure Variability Between Amlodipine and Losartan (PHASE4)
- Kanagawa Combination Anti-hypertensive Therapy (K-CAT) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Losartan/amlodipine or losartan/hydrochlorothiazide CI brief — competitive landscape report
- Losartan/amlodipine or losartan/hydrochlorothiazide updates RSS · CI watch RSS
- Yokohama City University Medical Center portfolio CI
Frequently asked questions about Losartan/amlodipine or losartan/hydrochlorothiazide
What is Losartan/amlodipine or losartan/hydrochlorothiazide?
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Who makes Losartan/amlodipine or losartan/hydrochlorothiazide?
Is Losartan/amlodipine or losartan/hydrochlorothiazide also known as anything else?
What drug class is Losartan/amlodipine or losartan/hydrochlorothiazide in?
What development phase is Losartan/amlodipine or losartan/hydrochlorothiazide in?
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Related
- Drug class: All Angiotensin II receptor blocker combination (ARB + calcium channel blocker or ARB + thiazide diuretic) drugs
- Target: All drugs targeting Angiotensin II type 1 receptor (AT1R); L-type voltage-gated calcium channels (amlodipine) or sodium-chloride cotransporter (hydrochlorothiazide)
- Manufacturer: Yokohama City University Medical Center — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension (high blood pressure)
- Also known as: Preminent (Hyzaar)
- Compare: Losartan/amlodipine or losartan/hydrochlorothiazide vs similar drugs
- Pricing: Losartan/amlodipine or losartan/hydrochlorothiazide cost, discount & access