{"id":"losartan-amlodipine-or-losartan-hydrochlorothiazide","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Peripheral edema (amlodipine formulation)"},{"rate":null,"effect":"Hyperuricemia (hydrochlorothiazide formulation)"},{"rate":null,"effect":"Hyperkalemia"}]},"_chembl":{"chemblId":"CHEMBL382821","moleculeType":"Small molecule","molecularWeight":"467.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Losartan blocks angiotensin II receptors, reducing vasoconstriction and aldosterone secretion. Amlodipine relaxes vascular smooth muscle by blocking L-type calcium channels, while hydrochlorothiazide reduces blood volume and sodium reabsorption. 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Hypertrophy, Left Ventricular","enrollment":90},{"nctId":"NCT00813722","phase":"PHASE4","title":"Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"1999-03","conditions":"Blood Pressure","enrollment":400},{"nctId":"NCT00684489","phase":"NA","title":"Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2003-09","conditions":"Hypertension","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":114,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Preminent (Hyzaar)"],"phase":"marketed","status":"active","brandName":"Losartan/amlodipine or losartan/hydrochlorothiazide","genericName":"Losartan/amlodipine or losartan/hydrochlorothiazide","companyName":"Yokohama City University Medical Center","companyId":"yokohama-city-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a fixed-dose combination of losartan (an angiotensin II receptor blocker) with either amlodipine (a calcium channel blocker) or hydrochlorothiazide (a thiazide diuretic) to lower blood pressure through multiple complementary pathways. Used for Hypertension (high blood pressure).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}