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Fimasartan; Hydrochlorothiazide
Fimasartan; Hydrochlorothiazide is a Angiotensin II receptor blocker + thiazide diuretic combination Small molecule drug developed by Stendhal Americas, S.A.. It is currently in Phase 3 development for Hypertension. Also known as: Diarakhor, Kanarb plus.
Fimasartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume and sodium reabsorption.
Fimasartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume and sodium reabsorption. Used for Hypertension.
At a glance
| Generic name | Fimasartan; Hydrochlorothiazide |
|---|---|
| Also known as | Diarakhor, Kanarb plus |
| Sponsor | Stendhal Americas, S.A. |
| Drug class | Angiotensin II receptor blocker + thiazide diuretic combination |
| Target | AT1 receptor (fimasartan); sodium-chloride cotransporter (hydrochlorothiazide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Fimasartan is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to AT1 receptors on blood vessels and other tissues, causing vasodilation and reduced blood pressure. Hydrochlorothiazide is a thiazide diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, increasing urine output and reducing blood volume. The combination provides complementary antihypertensive effects through different mechanisms.
Approved indications
- Hypertension
Common side effects
- Dizziness
- Fatigue
- Hyperuricemia
- Hypokalemia
- Hyperglycemia
- Cough
Key clinical trials
- An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ
- Fimasartan in the Senior Subjects (PHASE3)
- Combination of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects (PHASE1)
- Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects (PHASE1)
- A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide (PHASE2)
- Efficacy and Safety of Fimasartan Alone or Combined With HCTZ in Mexican Patients With Essential Hypertension (PHASE3)
- A Clinical Study to Evaluate Efficacy and Safety of Fimasartan/Hydrochlorothiazide Combination-therapy (PHASE3)
- A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan and Hydrochlorothiazide in Healthy Male Volunteers (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fimasartan; Hydrochlorothiazide CI brief — competitive landscape report
- Fimasartan; Hydrochlorothiazide updates RSS · CI watch RSS
- Stendhal Americas, S.A. portfolio CI
Frequently asked questions about Fimasartan; Hydrochlorothiazide
What is Fimasartan; Hydrochlorothiazide?
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Related
- Drug class: All Angiotensin II receptor blocker + thiazide diuretic combination drugs
- Target: All drugs targeting AT1 receptor (fimasartan); sodium-chloride cotransporter (hydrochlorothiazide)
- Manufacturer: Stendhal Americas, S.A. — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Also known as: Diarakhor, Kanarb plus
- Compare: Fimasartan; Hydrochlorothiazide vs similar drugs
- Pricing: Fimasartan; Hydrochlorothiazide cost, discount & access