Long-acting muscarinic antagonist (LAMA)
This page covers all Long-acting muscarinic antagonist (LAMA) drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Muscarinic M3 receptor, Glucocorticoid receptor, M3 muscarinic receptor, beta-2 adrenergic receptor, M3 muscarinic receptor; beta-2 adrenergic receptor.
Targets
Muscarinic M3 receptor · Glucocorticoid receptor, M3 muscarinic receptor, beta-2 adrenergic receptor · M3 muscarinic receptor; beta-2 adrenergic receptor · M3 muscarinic acetylcholine receptor · M3 muscarinic receptor · Muscarinic acetylcholine receptors (M1-M5) · Muscarinic acetylcholine receptor M1 · Muscarinic M3 receptor (umeclidinium); Beta-2 adrenergic receptor (vilanterol) · Glucocorticoid receptor (fluticasone); beta-2 adrenergic receptor (salmeterol); M3 muscarinic receptor (tiotropium) · M3 muscarinic receptor and beta-2 adrenergic receptor
Marketed (39)
- tiotropium bromide inhalation powder HandiHaler · GlaxoSmithKline · Respiratory
Tiotropium is a long-acting anticholinergic (antimuscarinic) agent that blocks muscarinic M3 receptors on airway smooth muscle to produce sustained bronchodilation. - Fluticasone furoate/umeclidinium/vilanterol · GlaxoSmithKline · Respiratory/Pulmonology
This triple-combination inhaler reduces airway inflammation and improves airflow by combining a corticosteroid, an anticholinergic, and a long-acting beta-2 agonist. - Umeclidinium/Vilanterol 62.5/25 mcgs · National Institute of Respiratory Diseases, Mexico · Respiratory
Umeclidinium is a long-acting anticholinergic that blocks muscarinic receptors to reduce airway smooth muscle contraction, while vilanterol is a long-acting beta-2 agonist that relaxes airway smooth muscle, together providing dual bronchodilation for sustained airway opening. - Aclidinium bromide & formoterol fumarate · University of Dundee · Respiratory / Pulmonology
Aclidinium bromide and formoterol fumarate is a combination bronchodilator that blocks muscarinic receptors (anticholinergic) and activates beta-2 adrenergic receptors to relax airway smooth muscle and improve airflow. - UMEC DPI · GlaxoSmithKline · Respiratory / Pulmonology
UMEC (umeclidinium) is a long-acting muscarinic antagonist that blocks M3 receptors in airway smooth muscle to produce bronchodilation. - Spiriva HandiHaler · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Respiratory
Spiriva HandiHaler delivers tiotropium, a long-acting anticholinergic agent that blocks muscarinic receptors in airway smooth muscle to cause bronchodilation and improve airflow. - TIO · GlaxoSmithKline · Respiratory / Pulmonology
Tiotropium is a long-acting anticholinergic bronchodilator that blocks muscarinic M3 receptors in airway smooth muscle to produce sustained airway relaxation. - tiotropium bromide (TIO) · GlaxoSmithKline · Respiratory / Pulmonology
Tiotropium is a long-acting anticholinergic (antimuscarinic) agent that blocks M3 muscarinic receptors on airway smooth muscle to produce sustained bronchodilation. - Tiotropium (SpirivaTM) · AstraZeneca · Respiratory
Tiotropium is a long-acting anticholinergic (muscarinic antagonist) that blocks M3 receptors on airway smooth muscle to produce sustained bronchodilation. - Atropine 0.01% · University Hospital, Strasbourg, France · Ophthalmology
Atropine blocks muscarinic acetylcholine receptors, preventing parasympathetic nervous system signaling. - Glycopyrrolate + Formoterol · Chiesi Farmaceutici S.p.A. · Respiratory / Pulmonology
Glycopyrrolate is an anticholinergic agent that blocks muscarinic receptors to reduce airway secretions and bronchoconstriction, while formoterol is a long-acting beta-2 agonist that relaxes airway smooth muscle. - Detrol · Upjohn · Metabolic
Detrol works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle. - umeclidinium bromide (UMEC) · GlaxoSmithKline · Respiratory / Pulmonology
Umeclidinium bromide is a long-acting muscarinic antagonist (anticholinergic) that blocks M3 receptors in airway smooth muscle to prevent bronchoconstriction and improve airflow. - UMEC/VI DPI · GlaxoSmithKline · Respiratory / Pulmonology
UMEC/VI is a combination of umeclidinium (a long-acting muscarinic antagonist) and vilanterol (a long-acting beta-2 agonist) that relaxes airway smooth muscle and improves airflow in chronic obstructive pulmonary disease. - Vesicare · Astellas Pharma · Urology
Vesicare works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle, reducing muscle contractions and urgency. - Placebo + Tiotropium · IRCCS Azienda Ospedaliero-Universitaria di Bologna · Respiratory / Pulmonology
Tiotropium is a long-acting anticholinergic bronchodilator that blocks muscarinic receptors in airway smooth muscle to produce sustained bronchodilation. - fluticasone/salmeterol, tiotropium · Taipei Veterans General Hospital, Taiwan · Respiratory / Pulmonology
This combination inhaler delivers a corticosteroid (fluticasone) to reduce airway inflammation and a long-acting beta-2 agonist (salmeterol) to dilate airways, plus a long-acting muscarinic antagonist (tiotropium) for sustained bronchodilation. - Atimos® · Chiesi Farmaceutici S.p.A. · Respiratory / Pulmonology
Atimos is a tiotropium bromide inhalation powder that acts as a long-acting anticholinergic (muscarinic antagonist) to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - umeclidinium bromide and vilanterol trifenatate · Chiesi Farmaceutici S.p.A. · Respiratory / Pulmonology
Umeclidinium is a long-acting muscarinic antagonist and vilanterol is a long-acting beta-2 agonist that together relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - Ditropan Xl · Hisamitsu Pharmaceutical Co., Inc. · Metabolic
Oxybutynin works by blocking the action of a chemical called acetylcholine on the bladder muscle, reducing spasms and urgency. - Sanctura · AbbVie · Urology
Sanctura works by blocking the action of a chemical called acetylcholine at the M3 receptor in the bladder muscle, reducing muscle contractions and urgency. - Tiotropium & olodaterol · University of Dundee · Respiratory / Pulmonology
Tiotropium and olodaterol is a combination of a long-acting muscarinic antagonist and a long-acting beta-2 agonist that work together to relax and open airways in the lungs. - TIO/OLO · GlaxoSmithKline · Respiratory / Pulmonology
TIO/OLO is a fixed-dose combination of tiotropium (a long-acting muscarinic antagonist) and olodaterol (a long-acting beta-2 agonist) that works synergistically to relax and open airways in chronic obstructive pulmonary disease. - Indacaterol/glycopyrronium · Orion Corporation, Orion Pharma · Respiratory / Pulmonology
Indacaterol is a long-acting beta-2 agonist that stimulates airway smooth muscle relaxation, while glycopyrronium is an anticholinergic that blocks muscarinic receptors to further dilate airways. - Revefenacin 175 µg, Formoterol 20 µg · University of Tennessee Graduate School of Medicine · Respiratory / Pulmonology
Revefenacin is a long-acting muscarinic antagonist that relaxes airway smooth muscle, while formoterol is a long-acting beta-2 agonist that further dilates airways, together providing bronchodilation for chronic obstructive pulmonary disease. - Atropine 0.04% · Beijing Tongren Hospital · Ophthalmology
Atropine blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity. - Enablex · AbbVie · Urology
Enablex works by blocking the action of a chemical called acetylcholine on the bladder muscle, which helps to relax the muscle and improve bladder control. - Vilanterol and Umeclidinium Bromide · Samsung Medical Center · Respiratory / Pulmonology
Vilanterol is a long-acting beta-2 agonist and umeclidinium bromide is a long-acting muscarinic antagonist that together relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - indacaterol/glycopyrronium 110/50 Breezhaler® · Wouter H. van Geffen · Respiratory / Pulmonology
Indacaterol is a long-acting beta-2 agonist and glycopyrronium is an anticholinergic that together relax airway smooth muscle and reduce mucus secretion to improve airflow in chronic obstructive pulmonary disease. - Olodaterol-Tiotropium · Fraunhofer-Institute of Toxicology and Experimental Medicine · Respiratory / Pulmonology
Olodaterol-Tiotropium is a fixed-dose combination of a long-acting beta-2 agonist (olodaterol) and a long-acting muscarinic antagonist (tiotropium) that work synergistically to relax airway smooth muscle and improve airflow. - Budesonide/formoterol and tiotropium · Brian J Lipworth · Respiratory/Pulmonology
This combination reduces airway inflammation and constriction by combining a corticosteroid with two bronchodilators that work through different pathways. - Urispas · Pain
- Homatropin · Gastroenterology
- Atropine Sulfate 1% Oph Soln · State University of New York College of Optometry · Ophthalmology
Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation. - Budesonide/Glycopyrronium/Formoterol Fumarate · AstraZeneca · Respiratory/Pulmonology
This triple-combination inhaler delivers a corticosteroid (budesonide) to reduce airway inflammation, a long-acting beta-2 agonist (formoterol) to dilate airways, and an anticholinergic (glycopyrronium) to further relax airway smooth muscle. - Anoro® Ellipta® · AstraZeneca · Respiratory / Pulmonology
Anoro Ellipta combines a long-acting beta-2 agonist and a long-acting muscarinic antagonist to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - Umeclidinium / Vilanterol Dry Powder Inhaler · Gary L. Pierce · Respiratory / Pulmonology
Umeclidinium is a long-acting anticholinergic that blocks muscarinic receptors to relax airway smooth muscle, while vilanterol is a long-acting beta-2 agonist that further dilates airways; together they provide sustained bronchodilation for COPD. - UMEC/VI · GlaxoSmithKline · Respiratory / Pulmonology
UMEC/VI is a combination of umeclidinium (a long-acting muscarinic antagonist) and vilanterol (a long-acting beta-2 agonist) that work together to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - Slow dose preemptive Atropine · Abant Izzet Baysal University · Toxicology / Emergency Medicine
Slow dose preemptive atropine blocks muscarinic acetylcholine receptors to prevent cholinergic toxicity and organophosphate poisoning effects.
Phase 3 pipeline (34)
- GSK573719 + GW642444 62.5/25 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719 (umeclidinium) and GW642444 (vilanterol) work together as a long-acting anticholinergic and long-acting beta-2 agonist to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - GSK573719/VI 125/25 · GlaxoSmithKline · Respiratory/Pulmonology
GSK573719/VI 125/25 is a combination of an inhaled long-acting muscarinic antagonist (LAMA) and long-acting beta-2 agonist (LABA) that relaxes airway smooth muscle and improves airflow in chronic obstructive pulmonary disease. - GSK 573719 62.5 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation. - Aclidinium Bromide 200 µg · AstraZeneca · Respiratory / Pulmonology
Aclidinium bromide is a long-acting muscarinic antagonist that blocks M3 receptors in airway smooth muscle to prevent bronchoconstriction and improve airflow. - GSK573719/GW642444 Inhalation Powder · GlaxoSmithKline · Respiratory
GSK573719/GW642444 is a combination of a long-acting muscarinic antagonist (LAMA) and a long-acting beta-2 agonist (LABA) that relaxes airway smooth muscle and reduces mucus secretion to improve airflow in chronic obstructive pulmonary disease. - Aclidinium Bromide 400 µg · AstraZeneca · Respiratory
Aclidinium bromide is a muscarinic M3 receptor antagonist that blocks acetylcholine signaling in airway smooth muscle, causing bronchodilation. - Inhaled Long-Acting Muscarinic Antagonist · Sanofi · Respiratory / Pulmonology
Blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion in chronic respiratory diseases. - BFF MDI (PT009) · Pearl Therapeutics, Inc. · Respiratory/Pulmonology
BFF MDI is a combination inhaled therapy containing budesonide, formoterol, and glycopyrronium that reduces airway inflammation and improves bronchodilation in chronic obstructive pulmonary disease. - Beclomethasone dipropionate/Formoterol Fumarate/Glycopyrronium · Chiesi Farmaceutici S.p.A. · Respiratory/Pulmonology
This triple-combination inhaler delivers a corticosteroid to reduce airway inflammation, a long-acting beta-2 agonist to relax airway smooth muscle, and an anticholinergic to further dilate airways. - Atropine Sulfate 03 · LitePharmTech Co., Ltd. · Emergency Medicine, Ophthalmology, Cardiology
Atropine sulfate is an anticholinergic agent that blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity. - GSK 573719 125 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation. - Atropine Ophthalmic 0.5% · Erasmus Medical Center · Ophthalmology
Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation. - GFF MDI (PT 003) · Pearl Therapeutics, Inc. · Respiratory / Pulmonology
GFF MDI is a combination inhaled corticosteroid and long-acting beta-2 agonist delivered via metered-dose inhaler for maintenance treatment of asthma and COPD. - FlF/VI + Tiotropium · Chiesi Farmaceutici S.p.A. · Respiratory/Pulmonology
FlF/VI is a fixed-dose combination of fluticasone furoate and vilanterol (long-acting beta-2 agonist and inhaled corticosteroid) combined with tiotropium (long-acting muscarinic antagonist) to provide multi-mechanism bronchodilation and anti-inflammatory effects in chronic obstructive pulmonary disease. - Atropine Ophthalmic 0.05% · Erasmus Medical Center · Ophthalmology
Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation. - FF/GW642444 Inhalation Powder · GlaxoSmithKline · Respiratory / Pulmonology
FF/GW642444 is a dual bronchodilator combining a long-acting beta-2 agonist (formoterol fumarate) and a long-acting muscarinic antagonist (GW642444) to relax airway smooth muscle and improve airflow. - CHF 5993 200/6/12.5 µg · Chiesi Farmaceutici S.p.A. · Respiratory/Pulmonology
CHF 5993 is a triple-combination inhaled therapy that combines a long-acting beta-2 agonist, long-acting muscarinic antagonist, and inhaled corticosteroid to improve airway function and reduce inflammation in chronic obstructive pulmonary disease. - GSK573719 125 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation. - GSK573719 62.5 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation. - Tiotropium Bromide Powder for Inhalation · Henan University of Traditional Chinese Medicine · Respiratory
Tiotropium bromide is a long-acting muscarinic antagonist that works by relaxing the airway muscles to improve breathing in patients with chronic obstructive pulmonary disease (COPD). - CHF 1535 · Chiesi Farmaceutici S.p.A. · Respiratory / Pulmonology
CHF 1535 is a dual bronchodilator that combines a long-acting beta-2 agonist with a long-acting muscarinic antagonist to improve airway function in chronic obstructive pulmonary disease. - BDP/FF + Tiotropium · Chiesi Farmaceutici S.p.A. · Respiratory
BDP/FF (beclomethasone/formoterol) is an inhaled corticosteroid plus long-acting beta-2 agonist combination that reduces airway inflammation and bronchospasm, while tiotropium is a long-acting muscarinic antagonist that provides sustained bronchodilation. - Beclometasone/Formoterol/Glycopyrrolate · Chiesi Farmaceutici S.p.A. · Respiratory/Pulmonology
This triple-combination inhaler delivers a corticosteroid (beclometasone) to reduce airway inflammation, a long-acting beta-2 agonist (formoterol) to dilate airways, and an anticholinergic (glycopyrrolate) to further relax airway smooth muscle. - Reference Product (Spiriva®) · Lupin, Inc. · Respiratory / Pulmonology
Tiotropium is a long-acting anticholinergic (muscarinic antagonist) that relaxes airway smooth muscle and reduces mucus secretion to improve airflow in chronic obstructive pulmonary disease. - Lower dose atropine sulfate eye drops · Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · Ophthalmology
Low-dose atropine competitively blocks muscarinic acetylcholine receptors in the eye to slow myopia progression. - BDP/FF/GB · Chiesi Farmaceutici S.p.A. · Respiratory/Pulmonology
BDP/FF/GB is a triple-combination inhaled corticosteroid/long-acting beta-2 agonist/long-acting muscarinic antagonist that reduces airway inflammation and improves bronchodilation through multiple pathways. - FF/UMEC/VI (100/31.25/25) mcg · GlaxoSmithKline · Respiratory/Pulmonology
FF/UMEC/VI is a triple-combination inhaled therapy that combines a long-acting beta-2 agonist, a long-acting muscarinic antagonist, and an inhaled corticosteroid to reduce airway inflammation and improve bronchodilation in chronic obstructive pulmonary disease. - OT-101 Ophthalmic Solution · Ocumension (Hong Kong) Limited · Ophthalmology
Low-dose atropine that slows axial elongation of the eye to control myopia progression in children. - Atropine Sulfate 01 · LitePharmTech Co., Ltd. · Emergency Medicine, Anesthesia, Ophthalmology, Toxicology
Atropine sulfate is an anticholinergic agent that blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity. - GSK573719/VI 62.5/25 · GlaxoSmithKline · Respiratory / Pulmonology
GSK573719/VI 62.5/25 is a combination of umeclidinium (long-acting muscarinic antagonist) and vilanterol (long-acting beta-2 agonist) that relaxes airway smooth muscle to improve airflow in chronic obstructive pulmonary disease. - GSK 573719 +GW642444 125/25 · GlaxoSmithKline · Respiratory / Pulmonology
This combination inhaler delivers a long-acting muscarinic antagonist (umeclidinium) and a long-acting beta-2 agonist (vilanterol) to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease. - Standard of Care COPD Treatment · AstraZeneca · Respiratory
Tiotropium bromide is a long-acting muscarinic antagonist that relaxes bronchial smooth muscle and increases lung function in patients with COPD. - GFF MDI · Pearl Therapeutics, Inc. · Respiratory / Pulmonology
GFF MDI is a combination inhaled corticosteroid and long-acting beta-2 agonist that reduces airway inflammation and improves bronchodilation in obstructive airway diseases. - Glycopyrronium/Formoterol Fumarate · AstraZeneca · Respiratory / Pulmonology
Glycopyrronium is an anticholinergic agent that blocks muscarinic receptors to reduce airway secretions and improve bronchial tone, while formoterol is a long-acting beta-2 agonist that relaxes airway smooth muscle to improve airflow.
Phase 2 pipeline (2)
- NVA237 200 µg · Novartis · Respiratory
NVA237 is a long-acting muscarinic antagonist that blocks the M3 muscarinic acetylcholine receptor in the airways, leading to bronchodilation. - CHF6001 DPI · Chiesi Farmaceutici S.p.A. · Respiratory
CHF6001 DPI is a dry powder inhaler formulation of a long-acting muscarinic antagonist.
Patent intelligence
- muscarinic antagonist patent landscape — aggregated cliff calendar, attackable patents, originator estates