M3 muscarinic receptor — Drug Target

All drugs that target M3 muscarinic receptor — marketed and clinical-stage. Includes 6 drug classes acting on this target.

Drug classes

Long-acting muscarinic antagonist (LAMA) · Muscarinic antagonist · Muscarinic receptor antagonist · Antimuscarinic agent · Long-acting muscarinic antagonist · Anticholinergic

Marketed (4)

• Placebo + Tiotropium · IRCCS Azienda Ospedaliero-Universitaria di Bologna · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Tiotropium is a long-acting anticholinergic bronchodilator that blocks muscarinic receptors in airway smooth muscle to produce sustained bronchodilation.
• tiotropium bromide (TIO) · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Tiotropium is a long-acting anticholinergic (antimuscarinic) agent that blocks M3 muscarinic receptors on airway smooth muscle to produce sustained bronchodilation.
• Tiotropium (SpirivaTM) · AstraZeneca · Long-acting muscarinic antagonist (LAMA) · Respiratory
  Tiotropium is a long-acting anticholinergic (muscarinic antagonist) that blocks M3 receptors on airway smooth muscle to produce sustained bronchodilation.
• Atimos® · Chiesi Farmaceutici S.p.A. · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Atimos is a tiotropium bromide inhalation powder that acts as a long-acting anticholinergic (muscarinic antagonist) to relax airway smooth muscle and improve airflow in chronic obstructive pulmonary disease.

Phase 3 pipeline (5)

• Tiotropium Bromide Powder for Inhalation · Henan University of Traditional Chinese Medicine · Muscarinic antagonist · Respiratory
  Tiotropium bromide is a long-acting muscarinic antagonist that works by relaxing the airway muscles to improve breathing in patients with chronic obstructive pulmonary disease (COPD).
• Standard of Care COPD Treatment · AstraZeneca · Muscarinic antagonist · Respiratory
  Tiotropium bromide is a long-acting muscarinic antagonist that relaxes bronchial smooth muscle and increases lung function in patients with COPD.
• Reference Product (Spiriva®) · Lupin, Inc. · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Tiotropium is a long-acting anticholinergic (muscarinic antagonist) that relaxes airway smooth muscle and reduces mucus secretion to improve airflow in chronic obstructive pulmonary disease.
• Urotol® · R-Pharm · Muscarinic receptor antagonist · Urology
  Urotol is a muscarinic receptor antagonist used to treat overactive bladder.
• Mictonetten 5 mg, coated tablet · APOGEPHA Arzneimittel GmbH · Antimuscarinic agent · Urology
  Mictonetten is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder symptoms.

Phase 2 pipeline (2)

• CHF6001 DPI · Chiesi Farmaceutici S.p.A. · Long-acting muscarinic antagonist · Respiratory
  CHF6001 DPI is a dry powder inhaler formulation of a long-acting muscarinic antagonist.
• A-101 Topical Solution 40% · Aclaris Therapeutics, Inc. · Anticholinergic · Dermatology
  A-101 Topical Solution 40% is a topical solution used to treat hyperhidrosis.