What are Anticholinergic drugs?

Anticholinergic drugs are pharmacologic agents that share a common mechanism (typically targeting Muscarinic acetylcholine receptor M4). 16 are currently marketed, with 10 more in clinical development.

What are the marketed Anticholinergic drugs?

Marketed Anticholinergic drugs include Incruse Ellipta, Spiriva, Librax, DIPHENIDOL HYDROCHLORIDE, Cuvposa, Pro-Banthine.

Anticholinergic

16 marketed 4 in Phase 3 6 in Phase 2

This page covers all Anticholinergic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M3, 5-hydroxytryptamine receptor 2A, Cytochrome P450 2D6, D(2) dopamine receptor.

Targets

Muscarinic acetylcholine receptor M4 · Muscarinic acetylcholine receptor M3 · 5-hydroxytryptamine receptor 2A, Cytochrome P450 2D6, D(2) dopamine receptor · Muscarinic acetylcholine receptor M1 · Muscarinic acetylcholine receptor M2 · Muscarinic acetylcholine receptors (M2 and M3) · Histamine H2 receptor · M3 receptors, beta 2 -adrenergic receptors · M1 muscarinic receptor · Muscarinic acetylcholine receptor

Marketed (16)

Incruse Ellipta · Glaxo Grp England · Respiratory · 3100
Umeclidinium works by blocking the M4 muscarinic acetylcholine receptor to relax airway smooth muscle and improve breathing.
Spiriva · Boehringer Ingelheim · Respiratory · 2500
Spiriva works by blocking the action of a chemical called acetylcholine, which causes airway muscles to contract and narrow the airways.
Librax · Roche · Immunology
DIPHENIDOL HYDROCHLORIDE · Gastroenterology
Cuvposa · Shionogi · Metabolic
Cuvposa works by blocking the action of a chemical called acetylcholine, which stimulates the muscarinic receptors in the body.
Pro-Banthine · Gastroenterology
Akineton · AbbVie · Neuroscience
Cantil · Sanofi · Gastroenterology
oxybutynin immediate release · Astellas Pharma Inc · Urology
Oxybutynin is an anticholinergic that blocks muscarinic receptors in the bladder, leading to relaxation of the detrusor muscle and increased bladder capacity.
Cogentin · Neuroscience
Atrovent · Neuroscience
Enlon-Plus · Mmt · Ophthalmology
Bentyl · Forest Labs Inc · Neuroscience
Tudorza Pressair · Covis · Respiratory
DUAKLIR PRESSAIR combines aclidinium, an anticholinergic, and formoterol, a beta 2 -adrenergic agonist, to provide bronchodilation in COPD.
MUSK pill · Shanghai Hutchison Pharmaceuticals Limited · Ophthalmology
MUSK pill works by inhibiting the activity of the muscarinic acetylcholine receptor.
Methylscopolamine · Fougera Pharms · Neuroscience

Phase 3 pipeline (4)

Oral Glycopyrrolate Liquid · Shionogi · Respiratory
Glycopyrrolate is an anticholinergic medication that works by blocking the action of acetylcholine, a neurotransmitter that stimulates the parasympathetic nervous system, thereby reducing secretions and slowing the heart rate.
low dose atropine eye drops · Ain Shams University · Ophthalmology
Atropine eye drops work by dilating the pupils to reduce the pressure in the eye.
Tropicamide Ophthalmic · Semnan University of Medical Sciences · Ophthalmology
Tropicamide Ophthalmic is an anticholinergic agent that works by blocking muscarinic receptors in the eye to induce mydriasis and cycloplegia.
Scopolamine Transdermal Patch [Transderm Scop] · Naval Aeromedical Research Unit, Dayton · Motion Sickness, Postoperative Nausea and Vomiting
Scopolamine acts as a muscarinic acetylcholine receptor antagonist, blocking the action of acetylcholine at muscarinic receptors in the central and peripheral nervous system.

Phase 2 pipeline (6)

Glycopyrronium MDI 7.2 micrograms · Pearl Therapeutics, Inc. · Respiratory
Glycopyrronium is an anticholinergic that works by blocking the action of acetylcholine at muscarinic receptors, leading to bronchodilation.
Glycopyrronium MDI · Pearl Therapeutics, Inc. · Respiratory
Anticholinergic
Dose 1 of glycopyrronium, 2.5% QD · Journey Medical Corporation · Ophthalmology
Glycopyrronium is an anticholinergic that works by blocking the action of acetylcholine at muscarinic receptors, leading to reduced salivation and sweating.
A-101 Topical Solution 40% · Aclaris Therapeutics, Inc. · Dermatology
A-101 Topical Solution 40% is a topical solution used to treat hyperhidrosis.
Ipratropium Bromide HFA Inhalation Aerosol · Pearl Therapeutics, Inc. · Respiratory
Anticholinergic agent that inhibits muscarinic acetylcholine receptors
A-101 Solution 40 · Aclaris Therapeutics, Inc. · Dermatology
A-101 Solution 40 is a topical solution used to treat hyperhidrosis.