Last reviewed · How we verify
Atropine Ophthalmic 0.5%
Atropine Ophthalmic 0.5% is a Anticholinergic agent / Muscarinic antagonist Small molecule drug developed by Erasmus Medical Center. It is currently in Phase 3 development for Myopia control in children (Phase 3), Cycloplegia for refraction, Pupil dilation for ophthalmic examination.
Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation. Used for Myopia control in children (Phase 3), Cycloplegia for refraction, Pupil dilation for ophthalmic examination.
At a glance
| Generic name | Atropine Ophthalmic 0.5% |
|---|---|
| Sponsor | Erasmus Medical Center |
| Drug class | Anticholinergic agent / Muscarinic antagonist |
| Target | Muscarinic acetylcholine receptors (M1-M5, primarily M1 and M3) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Atropine is an anticholinergic agent that competitively antagonizes muscarinic receptors on the iris sphincter muscle and ciliary muscle. This prevents parasympathetic-mediated pupil constriction and accommodation, resulting in mydriasis (pupil dilation) and cycloplegia (paralysis of accommodation). In the context of myopia control, atropine may work by reducing accommodation-induced axial elongation of the eye.
Approved indications
- Myopia control in children (Phase 3)
- Cycloplegia for refraction
- Pupil dilation for ophthalmic examination
Common side effects
- Blurred vision
- Photophobia
- Ocular irritation
- Systemic anticholinergic effects (rare with topical use)
Key clinical trials
- Dropless Pars Plana Vitrectomy Study (PHASE4)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- MAD Trial: Myopia Atropine Dose (PHASE3)
- The Pathophysiology of Orthostatic Hypotension (PHASE1)
- Modified Surgical Techniques for Pediatric Cataract Treatment (NA)
- Safety and Efficacy Study of 0.5%, 0.1% & 0.01% Atropine Treatment to Both Eyes In Treatment of Myopia In Children (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Atropine Ophthalmic 0.5% CI brief — competitive landscape report
- Atropine Ophthalmic 0.5% updates RSS · CI watch RSS
- Erasmus Medical Center portfolio CI
Frequently asked questions about Atropine Ophthalmic 0.5%
What is Atropine Ophthalmic 0.5%?
How does Atropine Ophthalmic 0.5% work?
What is Atropine Ophthalmic 0.5% used for?
Who makes Atropine Ophthalmic 0.5%?
What drug class is Atropine Ophthalmic 0.5% in?
What development phase is Atropine Ophthalmic 0.5% in?
What are the side effects of Atropine Ophthalmic 0.5%?
What does Atropine Ophthalmic 0.5% target?
Related
- Drug class: All Anticholinergic agent / Muscarinic antagonist drugs
- Target: All drugs targeting Muscarinic acetylcholine receptors (M1-M5, primarily M1 and M3)
- Manufacturer: Erasmus Medical Center — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Myopia control in children (Phase 3)
- Indication: Drugs for Cycloplegia for refraction
- Indication: Drugs for Pupil dilation for ophthalmic examination
- Compare: Atropine Ophthalmic 0.5% vs similar drugs
- Pricing: Atropine Ophthalmic 0.5% cost, discount & access