Muscarinic M3 receptor — Drug Target

All drugs that target Muscarinic M3 receptor — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Long-acting muscarinic antagonist (LAMA) · Anticholinergic agent / Antiperspirant · Muscarinic receptor agonist

Marketed (4)

• UMEC DPI · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  UMEC (umeclidinium) is a long-acting muscarinic antagonist that blocks M3 receptors in airway smooth muscle to produce bronchodilation.
• umeclidinium bromide (UMEC) · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Umeclidinium bromide is a long-acting muscarinic antagonist (anticholinergic) that blocks M3 receptors in airway smooth muscle to prevent bronchoconstriction and improve airflow.
• TIO · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Tiotropium is a long-acting anticholinergic bronchodilator that blocks muscarinic M3 receptors in airway smooth muscle to produce sustained airway relaxation.
• tiotropium bromide inhalation powder HandiHaler · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory
  Tiotropium is a long-acting anticholinergic (antimuscarinic) agent that blocks muscarinic M3 receptors on airway smooth muscle to produce sustained bronchodilation.

Phase 3 pipeline (8)

• GSK 573719 125 · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation.
• glycopyrronium Topical Wipes · Journey Medical Corporation · Anticholinergic agent / Antiperspirant · Dermatology
  Glycopyrronium is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce sweat gland secretion.
• GSK 573719 62.5 · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation.
• Pilocarpine HCl · Allergan · Muscarinic receptor agonist · Ophthalmology / Otolaryngology
  Pilocarpine HCl is a muscarinic acetylcholine receptor agonist that stimulates parasympathetic activity to increase salivary and lacrimal gland secretion.
• Aclidinium Bromide 200 µg · AstraZeneca · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Aclidinium bromide is a long-acting muscarinic antagonist that blocks M3 receptors in airway smooth muscle to prevent bronchoconstriction and improve airflow.
• Aclidinium Bromide 400 µg · AstraZeneca · Long-acting muscarinic antagonist (LAMA) · Respiratory
  Aclidinium bromide is a muscarinic M3 receptor antagonist that blocks acetylcholine signaling in airway smooth muscle, causing bronchodilation.
• GSK573719 125 · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation.
• GSK573719 62.5 · GlaxoSmithKline · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  GSK573719 is a long-acting muscarinic antagonist (LAMA) that blocks M3 receptors in airway smooth muscle to promote bronchodilation.