M3 muscarinic acetylcholine receptor — Drug Target

All drugs that target M3 muscarinic acetylcholine receptor — marketed and clinical-stage. Includes 5 drug classes acting on this target.

Drug classes

Muscarinic M3 receptor antagonist · Anticholinergic bronchodilator · Anticholinergic agent · Long-acting muscarinic antagonist (LAMA) · Muscarinic antagonist

Marketed (8)

• Solifenacin for 24 weeks · National Taiwan University Hospital · Muscarinic M3 receptor antagonist · Urology
  Solifenacin blocks muscarinic M3 receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Solifenacin succinate treatment · Barrie Urology Associates · Muscarinic M3 receptor antagonist · Urology
  Solifenacin succinate is a muscarinic M3 receptor antagonist that reduces involuntary bladder muscle contractions.
• Drug: ipratropium (AtroventTM) · AstraZeneca · Anticholinergic bronchodilator · Respiratory
  Ipratropium is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion.
• Oxybutynin chloride, extended-release · US Department of Veterans Affairs · Anticholinergic agent · Urology
  Oxybutynin chloride is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• solifenacin succinate suspension · Astellas Pharma Inc · Muscarinic M3 receptor antagonist · Urology
  Solifenacin is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder.
• Toviaz (Fesoterodine) · Weill Medical College of Cornell University · Muscarinic M3 receptor antagonist · Urology
  Fesoterodine is a muscarinic M3 receptor antagonist that relaxes bladder smooth muscle to reduce urinary incontinence and overactive bladder symptoms.
• Solifenacin PO · Seattle Urology Research Center · Muscarinic M3 receptor antagonist · Urology
  Solifenacin is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder.
• Spiriva HandiHaler · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Long-acting muscarinic antagonist (LAMA) · Respiratory
  Spiriva HandiHaler delivers tiotropium, a long-acting anticholinergic agent that blocks muscarinic receptors in airway smooth muscle to cause bronchodilation and improve airflow.

Phase 3 pipeline (4)

• Placebo to Tolterodine · Astellas Pharma Inc · Muscarinic M3 receptor antagonist · Urology
  Tolterodine is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder symptoms.
• Oxybutynin Transdermal Patch · University of California, Davis · Anticholinergic agent · Urology / Neurology
  Oxybutynin is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Inhaled Long-Acting Muscarinic Antagonist · Sanofi · Long-acting muscarinic antagonist (LAMA) · Respiratory / Pulmonology
  Blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion in chronic respiratory diseases.
• Fesoterodine PR · Pfizer · Muscarinic M3 receptor antagonist · Urology
  Fesoterodine is a muscarinic M3 receptor antagonist that relaxes bladder smooth muscle to reduce urinary incontinence and overactive bladder symptoms.

Phase 2 pipeline (1)

• NVA237 200 µg · Novartis · Muscarinic antagonist · Respiratory
  NVA237 is a long-acting muscarinic antagonist that blocks the M3 muscarinic acetylcholine receptor in the airways, leading to bronchodilation.