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Inhaled Long-Acting Muscarinic Antagonist
Inhaled Long-Acting Muscarinic Antagonist is a Long-acting muscarinic antagonist (LAMA) Small molecule drug developed by Sanofi. It is currently in Phase 3 development for Chronic obstructive pulmonary disease (COPD), Asthma (as add-on therapy).
Blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion in chronic respiratory diseases.
Blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion in chronic respiratory diseases. Used for Chronic obstructive pulmonary disease (COPD), Asthma (as add-on therapy).
At a glance
| Generic name | Inhaled Long-Acting Muscarinic Antagonist |
|---|---|
| Sponsor | Sanofi |
| Drug class | Long-acting muscarinic antagonist (LAMA) |
| Target | M3 muscarinic acetylcholine receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Pulmonology |
| Phase | Phase 3 |
Mechanism of action
Long-acting muscarinic antagonists (LAMAs) inhibit M3 muscarinic receptors on airway smooth muscle and mucus-secreting cells, preventing acetylcholine-induced contraction and secretion. When inhaled, they provide sustained bronchodilation over 24 hours, improving airflow and reducing symptoms in obstructive airway diseases. This mechanism is particularly effective in COPD and asthma where cholinergic tone contributes to airway obstruction.
Approved indications
- Chronic obstructive pulmonary disease (COPD)
- Asthma (as add-on therapy)
Common side effects
- Dry mouth
- Headache
- Tremor
- Urinary retention
- Tachycardia
Key clinical trials
- Pooled Analysis of Single-arm Studies of Budesonide/Glycopyrronium/Formoterol (BGF) in Routine Care Setting
- A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation (PHASE4)
- Triple Therapy in Real-life: Impact on Adherence and Health Status (TRITRIAL)
- Real-World Effectiveness of a Triple Combination BDP/FF/GB Extrafine in a Single Pressurised Metered Dose Inhaler in Brazilian COPD Patients
- Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation (NA)
- Fractional Exhaled Nitric Oxide and Exacerbations of COPD
- Immuno-inflammatory Response of Erdosteine in COPD (NA)
- Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Inhaled Long-Acting Muscarinic Antagonist CI brief — competitive landscape report
- Inhaled Long-Acting Muscarinic Antagonist updates RSS · CI watch RSS
- Sanofi portfolio CI
Frequently asked questions about Inhaled Long-Acting Muscarinic Antagonist
What is Inhaled Long-Acting Muscarinic Antagonist?
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Related
- Drug class: All Long-acting muscarinic antagonist (LAMA) drugs
- Target: All drugs targeting M3 muscarinic acetylcholine receptor
- Manufacturer: Sanofi — full pipeline
- Therapeutic area: All drugs in Respiratory / Pulmonology
- Indication: Drugs for Chronic obstructive pulmonary disease (COPD)
- Indication: Drugs for Asthma (as add-on therapy)
- Compare: Inhaled Long-Acting Muscarinic Antagonist vs similar drugs
- Pricing: Inhaled Long-Acting Muscarinic Antagonist cost, discount & access