Sanofi S.A. (SNY)

Quick facts

Marketed products

• Lantus · Metabolic · revenue 4800
  Lantus works by mimicking the action of natural insulin to lower blood sugar levels.
• Rhgaa · Metabolic · revenue 1100
  Rhgaa works by replacing the deficient enzyme in patients with Pompe disease.
• Aubagio · Immunology · revenue 1100
  Teriflunomide inhibits dihydroorotate dehydrogenase, reducing activated lymphocytes in the CNS.
• Fabrazyme · Metabolic · revenue 1000
  Fabrazyme works by replacing the deficient enzyme alpha-Gal A to break down and remove toxic globotriaosylceramide.
• Praluent · Metabolic · revenue 857
  Praluent blocks the PCSK9 protein, which helps remove LDL cholesterol from the bloodstream, thereby reducing cholesterol levels.
• Cerezyme · Cardiovascular · revenue 800
  Cerezyme replaces the deficient enzyme in patients with Gaucher disease, allowing for the breakdown of glucocerebroside.
• Cerdelga · Metabolic · revenue 400
  Cerdelga works by inhibiting the enzyme ceramide glucosyltransferase, which is involved in the production of glucosylceramide.
• agalsidase beta (GZ419828) · Rare genetic disease / Lysosomal storage disorder
  Agalsidase beta is a recombinant human alpha-galactosidase A enzyme that breaks down globotriaosylceramide (Gb3) accumulation in cells.
• Campath · Oncology
  Campath works by binding to a specific protein on the surface of immune cells, marking them for destruction.
• Gaviscon · Cardiovascular
• Ceredase · Neuroscience
• Alirocumab SAR236553
• alpha-glucosidase inhibitors
• Mytelase · Neuroscience
• amisulpride and risperidone
• Cartonic · Cardiovascular
• Antihyperglycemic Drug · Diabetes
  Antihyperglycemic drugs lower blood glucose levels through various mechanisms such as enhancing insulin secretion, improving insulin sensitivity, or reducing hepatic glucose production.
• Apidra (insulin glulisine) · Diabetes
  Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to promote glucose uptake and lower blood glucose levels.
• Artesunate + Sulfadoxine-Pyrimethamine · Infectious Disease
  Artesunate kills malaria parasites by generating reactive oxygen species, while sulfadoxine-pyrimethamine inhibits folate synthesis in the parasite, providing synergistic antimalarial activity.
• arthemether + lumefantrine · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and interfering with their DNA replication.
• Neogaa · Metabolic
  AVALGLUCOSIDASE ALFA breaks down glycogen in lysosomes to treat Pompe disease.
• Bacillus Clausii Multi ATB Resist · Gastroenterology
  Bacillus clausii is a spore-forming probiotic bacterium that restores and maintains healthy gut microbiota, particularly in cases of antibiotic-associated dysbiosis.
• Background Therapy
  Background Therapy is a general term referring to the standard or baseline treatment regimen used as a control or foundation in clinical studies, rather than a specific drug with a defined mechanism.
• Bacterial Lysates · Immunology; Infectious Disease
  Bacterial lysates stimulate innate and adaptive immune responses by exposing the immune system to bacterial antigens, enhancing respiratory tract defenses and reducing infection susceptibility.
• Tornalate · Respiratory
• Receptal · Other
• Cabazitaxel (XRP6258) · Oncology
  Cabazitaxel is a microtubule-stabilizing taxane that binds to β-tubulin and prevents microtubule depolymerization, leading to cell cycle arrest and apoptosis in cancer cells.
• Osteobios · Metabolic
  Calcitonin salmon acts as a calcitonin receptor agonist, primarily affecting bone, with additional effects on the kidneys and gastrointestinal tract.
• Miacalcin · Hematology
  Calcitonin salmon acts as a calcitonin receptor agonist, primarily affecting bone, with additional effects on the kidneys and gastrointestinal tract.
• Calcium and Magnesium · Nutritional/Metabolic
  Calcium and magnesium are essential mineral supplements that replenish electrolyte levels and support cellular function, muscle contraction, and nerve transmission.
• Calcium & Vitamine D3 · Bone Health / Musculoskeletal
  Calcium and Vitamin D3 work together to promote bone mineralization and maintain serum calcium levels by enhancing intestinal calcium absorption and regulating calcium-phosphate homeostasis.
• Cerezyme® / Imiglucerase · Rare genetic disease / Lysosomal storage disorder
  Imiglucerase is a recombinant glucocerebrosidase enzyme that breaks down glucocerebroside, a lipid that accumulates in Gaucher disease.
• Charcoal · Other
• Aralen · Immunology
  Aralen works by accumulating in the acidic compartments of the malaria parasite, disrupting its metabolism and ultimately leading to its death.
• Claritin® · Immunology / Allergy
  Claritin blocks histamine H1 receptors on cells, preventing histamine-mediated allergic responses.
• clindamycin 1% / benzoyl peroxide 5% tube · Dermatology
  Clindamycin kills acne-causing bacteria while benzoyl peroxide reduces sebum production and provides additional antimicrobial and keratolytic effects.
• Clolar · Oncology
  Clolar works by inhibiting the enzyme responsible for DNA synthesis, thereby preventing cancer cells from reproducing.
• Clomid · Pain
• clopidogrel (SR25990C) · Cardiovascular
  Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits ADP-induced platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.
• Coarsucam · Other

Phase 3 pipeline

• Acenocoumarol VKA · Cardiovascular
  Acenocoumarol inhibits vitamin K-dependent clotting factors (II, VII, IX, X) by antagonizing vitamin K recycling, thereby reducing thrombin generation and preventing blood clot formation.
• acetylsalicyclic acid (ASA) · Cardiovascular
  Acetylsalicylic acid (ASA) works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes.
• afuzosin · Other
• alfuzosin (SL770499) · Urology
  Alfuzosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck, improving urine flow.
• alpha-GI · Diabetes
  Alpha-glucosidase inhibitor that slows carbohydrate digestion and glucose absorption in the small intestine.
• ambroxol BIH1526 · Respiratory
  Ambroxol BIH1526 is a mucolytic agent that works by increasing the concentration of glutathione in the airways, which helps to break down and clear mucus.
• amibegron (SR58611A) · Urology
  Amibegron is a beta-3 adrenergic receptor agonist.
• Antidiabetic background therapy · Diabetes
  Antidiabetic background therapy refers to baseline glucose-lowering medications used as a control or comparator arm in diabetes clinical trials.
• Asthma Controller Therapies · Respiratory/Pulmonology
  Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways.
• Asthma Reliever Therapies · Respiratory/Pulmonology
  Asthma Reliever Therapies from Sanofi work to rapidly open airways and reduce airway constriction in asthma patients.
• carboplatin/paclitaxel (CP)
• ChimeriVax™-JE · Infectious Disease / Immunology
  ChimeriVax-JE is a live attenuated chimeric vaccine that combines the yellow fever vaccine backbone with Japanese encephalitis virus envelope genes to induce protective immunity against Japanese encephalitis.
• ChimeriVax-JE, Japanese Encephalitis vaccine · Infectious Disease / Immunology
  ChimeriVax-JE is a live attenuated chimeric vaccine that uses a yellow fever virus backbone expressing Japanese encephalitis virus envelope proteins to induce protective immunity against Japanese encephalitis.
• Ciclesonide (XRP1526) · Respiratory / Pulmonology
  Ciclesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors in lung tissue.
• Clopidogrel (SR25990) · Cardiovascular
  Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits ADP-induced platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.
• Clostridium difficile vaccine · Infectious Disease / Immunology
  This vaccine stimulates the immune system to produce antibodies and cellular immunity against Clostridium difficile toxins and bacterial antigens to prevent infection and disease.
• Dermacid Silver (Lactic acid) · Dermatology
  Lactic acid works as a topical antimicrobial and keratolytic agent that reduces bacterial colonization and promotes skin healing through acidification and exfoliation.
• docetaxel and carboplatin · Oncology
  Docetaxel is a microtubule inhibitor that disrupts cell division, while carboplatin is a platinum-based alkylating agent that cross-links DNA, both leading to cell death.
• Docetaxel/DDP · Oncology
  Docetaxel/DDP is a combination chemotherapy regimen that uses a taxane microtubule stabilizer paired with a platinum-based DNA crosslinking agent to inhibit cancer cell division and induce apoptosis.
• Docetaxel (XRP6976) · Oncology
  Docetaxel stabilizes microtubules by binding to β-tubulin, preventing their depolymerization and causing cell cycle arrest and apoptosis in rapidly dividing cancer cells.
• DOCETAXEL(XRP6976) + MODAFINIL · Oncology
  Docetaxel stabilizes microtubules to inhibit cancer cell division, while modafinil enhances wakefulness and may improve treatment tolerability and cognitive function during chemotherapy.
• doxorubicine + cyclophosphamide combined · Oncology
  Doxorubicin is a topoisomerase II inhibitor that intercalates DNA, while cyclophosphamide is an alkylating agent that cross-links DNA.
• doxorubicine + cyclophosphamide sequential · Oncology
  Doxorubicin is a topoisomerase II inhibitor that intercalates DNA, while cyclophosphamide is an alkylating agent that cross-links DNA.
• doxorubicine + docetaxel combined
• Doxorubicine + docetaxel sequential · Oncology
  A sequential chemotherapy regimen combining doxorubicin (an anthracycline topoisomerase II inhibitor) followed by docetaxel (a taxane microtubule stabilizer) to maximize cytotoxic effects against cancer cells.
• DTaP-IPV combined vaccine · Immunology / Infectious Disease Prevention
  This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and poliovirus by delivering inactivated toxins and viral antigens.
• DTaP-IPV//PRP~T combined vaccine · Immunology / Infectious Disease
  This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b.
• DTaP//PRP-T Combined Vaccine · Immunology
  This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and Haemophilus influenzae type b (Hib) by presenting inactivated toxoids and conjugated polysaccharide antigens.
• DTaP vaccine · Immunology
  DTaP vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria toxin, tetanus toxin, and pertussis antigens.
• Dupilumab (SAR231893/REGN668) · Immunology; Dermatology; Respiratory
  Dupilumab is a monoclonal antibody that blocks the IL-4 receptor alpha subunit, inhibiting signaling of IL-4 and IL-13 cytokines involved in type 2 inflammation.
• Efanesoctocog Alfa BIVV001 · Hematology
  Efanesoctocog alfa (BIVV001) is a bispecific antibody that bridges Factor IX and Factor X to restore the intrinsic tenase complex activity in hemophilia A patients lacking functional Factor VIII.
• Eliglustat GZ385660 · Rare/Genetic Disorders
  Eliglustat is a glucosylceramide synthase (GCS) inhibitor that reduces the production of glucosylceramide, a lipid that accumulates in Gaucher disease.
• Emollient (moisturizer) · Dermatology
  An emollient moisturizer works by forming an occlusive barrier on the skin surface to reduce transepidermal water loss and restore skin hydration.
• Enoxaparin sodium (XRP4563) · Cardiovascular
  Enoxaparin sodium is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factors Xa and IIa.
• epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile · Oncology
  Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells.
• epidoxorubicine, docetaxel, ciclophosphamide, methotrexate, fluorouracile · Oncology
  Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells. Docetaxel is a taxane that stabilizes microtubules, preventing cell division and leading to cell death. Ciclophosphamide is an alkylating agent that adds an alkyl group to DNA, causing cross-linking and DNA damage. Methotrexate is an antifolate that inhibits dihydrofolate reductase, leading to a decrease in DNA synthesis and cell proliferation. Fluorouracile is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair.
• epidoxorubicine, docetaxel, cyclophosphamide · Oncology
  Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells. Docetaxel is a taxane that stabilizes microtubules, preventing cell division and leading to cell death. Cyclophosphamide is an alkylating agent that adds an alkyl group to DNA, causing cross-linking and DNA damage, which ultimately leads to cell death.
• Eplivanserin (SR46349) · Sexual Health / Urology
  Eplivanserin is a selective serotonin 5-HT2A receptor antagonist that modulates serotonergic signaling to treat sexual dysfunction.
• FDC KETOPROFEN+OMEPRAZOLE · Pain management / Gastroenterology
  This fixed-dose combination reduces pain and inflammation via ketoprofen (NSAID) while protecting the stomach lining via omeprazole (proton pump inhibitor).
• FEX60/PE10 · Allergy/Immunology
  FEX60/PE10 is a fixed-dose combination of fexofenadine (a selective H1-receptor antagonist) and pseudoephedrine (a sympathomimetic decongestant) that reduces allergic symptoms and nasal congestion.

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Sanofi S.A. portfolio CI brief
• Sanofi S.A. pipeline updates RSS