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ChimeriVax-JE, Japanese Encephalitis vaccine
ChimeriVax-JE, Japanese Encephalitis vaccine is a Live attenuated chimeric vaccine Biologic drug developed by Sanofi. It is currently in Phase 3 development for Japanese encephalitis prevention in endemic and at-risk populations. Also known as: ChimeriVax™.
ChimeriVax-JE is a live attenuated chimeric vaccine that uses a yellow fever virus backbone expressing Japanese encephalitis virus envelope proteins to induce protective immunity against Japanese encephalitis.
ChimeriVax-JE is a live attenuated chimeric vaccine that uses a yellow fever virus backbone expressing Japanese encephalitis virus envelope proteins to induce protective immunity against Japanese encephalitis. Used for Japanese encephalitis prevention in endemic and at-risk populations.
At a glance
| Generic name | ChimeriVax-JE, Japanese Encephalitis vaccine |
|---|---|
| Also known as | ChimeriVax™ |
| Sponsor | Sanofi |
| Drug class | Live attenuated chimeric vaccine |
| Modality | Biologic |
| Therapeutic area | Infectious Disease / Immunology |
| Phase | Phase 3 |
Mechanism of action
The vaccine combines the attenuated yellow fever 17D vaccine strain with genes encoding the prM and E surface proteins of Japanese encephalitis virus. This chimeric approach leverages the well-established safety and immunogenicity of the YF 17D backbone while presenting JE-specific antigens to elicit both humoral and cellular immune responses against Japanese encephalitis virus.
Approved indications
- Japanese encephalitis prevention in endemic and at-risk populations
Common side effects
- Injection site reactions (pain, erythema, swelling)
- Fever
- Headache
- Myalgia
- Fatigue
Key clinical trials
- Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines (PHASE3)
- Immunogenicity and Safety of ChimeriVax™ Japanese Encephalitis Vaccine in Thai Toddlers and Children (PHASE2)
- Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis. (PHASE3)
- A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVax™-JE and JE-VAX (PHASE3)
- Study of Live Attenuated ChimeriVax™-Japanese Encephalitis Vaccine (PHASE2)
- Study of Live Attenuated Japanese Encephalitis Vaccine (ChimeriVax™-JE) and Yellow Fever Vaccine (STAMARIL®) (PHASE2)
- Safety and Efficacy Study of ChimeriVax™-JE and JE Inactivated Mouse Brain Vaccine in Children of Descending Age (PHASE2)
- A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVaxTM-JE and JE-VAX (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ChimeriVax-JE, Japanese Encephalitis vaccine CI brief — competitive landscape report
- ChimeriVax-JE, Japanese Encephalitis vaccine updates RSS · CI watch RSS
- Sanofi portfolio CI
Frequently asked questions about ChimeriVax-JE, Japanese Encephalitis vaccine
What is ChimeriVax-JE, Japanese Encephalitis vaccine?
How does ChimeriVax-JE, Japanese Encephalitis vaccine work?
What is ChimeriVax-JE, Japanese Encephalitis vaccine used for?
Who makes ChimeriVax-JE, Japanese Encephalitis vaccine?
Is ChimeriVax-JE, Japanese Encephalitis vaccine also known as anything else?
What drug class is ChimeriVax-JE, Japanese Encephalitis vaccine in?
What development phase is ChimeriVax-JE, Japanese Encephalitis vaccine in?
What are the side effects of ChimeriVax-JE, Japanese Encephalitis vaccine?
Related
- Drug class: All Live attenuated chimeric vaccine drugs
- Manufacturer: Sanofi — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Immunology
- Indication: Drugs for Japanese encephalitis prevention in endemic and at-risk populations
- Also known as: ChimeriVax™
- Compare: ChimeriVax-JE, Japanese Encephalitis vaccine vs similar drugs
- Pricing: ChimeriVax-JE, Japanese Encephalitis vaccine cost, discount & access