{"name":"Sanofi S.A.","slug":"sanofi","ticker":"SNY","exchange":"NASDAQ","domain":"sanofi.com","description":"Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Synthélabo merged with Aventis and renamed to Sanofi-Aventis, which were each the product of several previous mergers. It changed its name back to Sanofi in May 2011. The company trades as \"SAN\" on Euronext Paris and \"SNY\" on Nasdaq in the United States, and is a component of the Euro Stoxx 50 stock market index. In 2023, the company’s seat in the Forbes Global 2000 was 89.","hq":"Paris, France","founded":1973,"employees":"74846","ceo":"Paul Hudson","sector":"Big Pharma","stockPrice":47.02,"stockChange":0.19,"stockChangePercent":0.41,"marketCap":"$114.5B","metrics":{"revenue":46715998208,"revenueGrowth":6.9,"grossMargin":72.3,"rdSpend":0,"netIncome":4938999808,"cash":7673999872,"dividendYield":4.69,"peRatio":20.3,"fiscalYear":"FY2026"},"revenueBreakdown":[{"name":"Lantus","genericName":"INSULIN GLARGINE","slug":"insulin-glargine","revenue":4800000000,"yoyGrowth":0,"percentOfTotal":45.5},{"name":"Aubagio","genericName":"TERIFLUNOMIDE","slug":"teriflunomide","revenue":1100000000,"yoyGrowth":0,"percentOfTotal":10.4},{"name":"Rhgaa","genericName":"ALGLUCOSIDASE ALFA","slug":"alglucosidase-alfa","revenue":1100000000,"yoyGrowth":0,"percentOfTotal":10.4},{"name":"Fabrazyme","genericName":"AGALSIDASE 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Anti-thymocyte Immunoglobulin","genericName":"Rabbit Anti-thymocyte Immunoglobulin","slug":"rabbit-anti-thymocyte-immunoglobulin","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"SAR408701","genericName":"SAR408701","slug":"sar408701","phase":"phase_3","mechanism":"SAR408701 is a bispecific antibody that simultaneously engages CD40 on antigen-presenting cells and 4-1BB on T cells to enhance anti-tumor immune responses.","indications":["Advanced or metastatic solid tumors (in combination with checkpoint inhibitors)"],"catalyst":""},{"name":"SAR444836","genericName":"SAR444836","slug":"sar444836","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"SR34006","genericName":"SR34006","slug":"sr34006","phase":"phase_3","mechanism":"SR34006 is a selective antagonist of the chemokine receptor CCR2, which blocks the recruitment of monocytes and inflammatory cells to sites of inflammation.","indications":["Diabetic kidney disease"],"catalyst":""},{"name":"TIV-HA formulation 1 at high dose","genericName":"TIV-HA formulation 1 at high dose","slug":"tiv-ha-formulation-1-at-high-dose","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Thiocolchicoside+Ketoprofen","genericName":"Thiocolchicoside+Ketoprofen","slug":"thiocolchicoside-ketoprofen","phase":"phase_3","mechanism":"Thiocolchicoside reduces muscle spasticity through GABA-A receptor modulation, while ketoprofen inhibits cyclooxygenase enzymes to reduce inflammation and pain.","indications":["Acute musculoskeletal pain and spasticity","Muscle contractures and spasticity associated with neurological conditions"],"catalyst":""},{"name":"Topical calcineurin inhibitors","genericName":"Topical calcineurin inhibitors","slug":"topical-calcineurin-inhibitors","phase":"phase_3","mechanism":"Topical calcineurin inhibitors block the action of calcineurin, a protein involved in the activation of T-cells, thereby reducing inflammation.","indications":["Atopic dermatitis","Psoriasis"],"catalyst":""},{"name":"Trivalent inactivated influenza vaccine","genericName":"Trivalent inactivated influenza vaccine","slug":"trivalent-inactivated-influenza-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"VAQTA","genericName":"VAQTA","slug":"vaqta","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Warfarin VKA","genericName":"Warfarin VKA","slug":"warfarin-vka","phase":"phase_3","mechanism":"Warfarin inhibits vitamin K-dependent clotting factors (II, VII, IX, X) by blocking the vitamin K epoxide reductase enzyme, thereby reducing thrombin generation and preventing blood clot formation.","indications":["Atrial fibrillation for stroke prevention","Venous thromboembolism (DVT/PE) treatment and prevention","Mechanical heart valve thromboprophylaxis","Post-myocardial infarction thromboprophylaxis"],"catalyst":""},{"name":"alpha-GI","genericName":"alpha-GI","slug":"alpha-gi","phase":"phase_3","mechanism":"Alpha-glucosidase inhibitor that slows carbohydrate digestion and glucose absorption in the small intestine.","indications":["Type 2 diabetes mellitus","Impaired glucose tolerance"],"catalyst":""},{"name":"lactoserum","genericName":"lactoserum","slug":"lactoserum","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"valproate microgranules","genericName":"valproate microgranules","slug":"valproate-microgranules","phase":"marketed","mechanism":"Valproate inhibits histone deacetylase and enhances GABAergic neurotransmission, leading to increased GABA levels and neuronal stabilization.","indications":["Epilepsy (seizure disorders)","Bipolar disorder (acute mania)","Migraine prophylaxis"],"catalyst":""},{"name":"(LMW)heparin","genericName":"(LMW)heparin","slug":"lmw-heparin","phase":"phase_3","mechanism":"Low-molecular-weight heparin inhibits blood coagulation by enhancing the activity of antithrombin III, which inactivates clotting factors Xa and IIa.","indications":["Venous thromboembolism prophylaxis","Treatment of deep vein thrombosis","Treatment of pulmonary embolism","Acute coronary syndrome"],"catalyst":""},{"name":"14C-microtracer","genericName":"14C-microtracer","slug":"14c-microtracer","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ALN-AT3SC","genericName":"ALN-AT3SC","slug":"aln-at3sc","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ARD6562, Docetaxel","genericName":"ARD6562, Docetaxel","slug":"ard6562-docetaxel","phase":"phase_2","mechanism":"ARD6562, Docetaxel, is a microtubule inhibitor that disrupts cell division.","indications":["Breast cancer","Non-small cell lung cancer","Prostate cancer"],"catalyst":""},{"name":"AVE2268","genericName":"AVE2268","slug":"ave2268","phase":"phase_2","mechanism":"AVE2268 is a small molecule that targets the SGLT2 receptor.","indications":["Type 2 diabetes"],"catalyst":""},{"name":"AVE7688","genericName":"AVE7688","slug":"ave7688","phase":"phase_2","mechanism":"AVE7688 is a small molecule that targets the SGLT2 receptor.","indications":["Type 2 diabetes"],"catalyst":""},{"name":"AVE8062","genericName":"AVE8062","slug":"ave8062","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Acenocoumarol VKA","genericName":"Acenocoumarol VKA","slug":"acenocoumarol-vka","phase":"phase_3","mechanism":"Acenocoumarol inhibits vitamin K-dependent clotting factors (II, VII, IX, X) by antagonizing vitamin K recycling, thereby reducing thrombin generation and preventing blood clot formation.","indications":["Atrial fibrillation for stroke prevention","Venous thromboembolism (deep vein thrombosis and pulmonary embolism) prevention and treatment","Mechanical heart valve thromboprophylaxis","Post-myocardial infarction thromboprophylaxis"],"catalyst":""},{"name":"Adlyxin","genericName":"LIXISENATIDE","slug":"lixisenatide","phase":"marketed","mechanism":"Adlyxin works by mimicking the action of the GLP-1 hormone to help regulate blood sugar levels.","indications":["Diabetes mellitus type 2"],"catalyst":""},{"name":"Alirocumab SAR236553","genericName":"Alirocumab SAR236553","slug":"alirocumab-sar236553","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Amaryl","genericName":"GLIMEPIRIDE","slug":"glimepiride","phase":"marketed","mechanism":"Amaryl works by binding to the sulfonylurea receptor 1 (SUR1) and Kir6.2 subunit of the ATP-sensitive potassium channel, closing the channel and depolarizing the pancreatic beta cell membrane, leading to insulin release.","indications":["Diabetes mellitus type 2","Treatment Refractory Type 2 Diabetes Mellitus"],"catalyst":""},{"name":"Amlitelimab DP1","genericName":"Amlitelimab DP1","slug":"amlitelimab-dp1","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Antihyperglycemic Drug","genericName":"Antihyperglycemic Drug","slug":"antihyperglycemic-drug","phase":"marketed","mechanism":"Antihyperglycemic drugs lower blood glucose levels through various mechanisms such as enhancing insulin secretion, improving insulin sensitivity, or reducing hepatic glucose production.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Apidra","genericName":"INSULIN GLULISINE","slug":"insulin-glulisine","phase":"marketed","mechanism":"Insulin glulisine lowers blood glucose by stimulating glucose uptake in muscles and fat, and by inhibiting liver glucose production.","indications":["Diabetes mellitus"],"catalyst":""},{"name":"Apidra (insulin glulisine)","genericName":"Apidra (insulin glulisine)","slug":"apidra-insulin-glulisine","phase":"marketed","mechanism":"Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to promote glucose uptake and lower blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Arava","genericName":"LEFLUNOMIDE","slug":"leflunomide","phase":"marketed","mechanism":"Arava works by inhibiting the enzyme Cytochrome P450 1A2, which is involved in the production of inflammatory chemicals in the body.","indications":["Psoriasis with arthropathy","Rheumatoid arthritis"],"catalyst":""},{"name":"Artesunate + Sulfadoxine-Pyrimethamine","genericName":"Artesunate + Sulfadoxine-Pyrimethamine","slug":"artesunate-sulfadoxine-pyrimethamine","phase":"marketed","mechanism":"Artesunate kills malaria parasites by generating reactive oxygen species, while sulfadoxine-pyrimethamine inhibits folate synthesis in the parasite, providing synergistic antimalarial activity.","indications":["Uncomplicated malaria caused by Plasmodium falciparum","Malaria treatment in endemic regions"],"catalyst":""},{"name":"Asthma Controller Therapies","genericName":"Asthma Controller Therapies","slug":"asthma-controller-therapies","phase":"phase_3","mechanism":"Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways.","indications":["Asthma maintenance therapy"],"catalyst":""},{"name":"Asthma Reliever Therapies","genericName":"Asthma Reliever Therapies","slug":"asthma-reliever-therapies","phase":"phase_3","mechanism":"Asthma Reliever Therapies from Sanofi work to rapidly open airways and reduce airway constriction in asthma patients.","indications":["Asthma symptom relief"],"catalyst":""},{"name":"Avapro","genericName":"IRBESARTAN","slug":"irbesartan","phase":"marketed","mechanism":"Type-1 angiotensin II receptor","indications":["Diabetic renal disease","Hypertensive disorder"],"catalyst":""},{"name":"Avapro","genericName":"IRBESARTAN HYDROCHLORIDE","slug":"irbesartan-hydrochloride","phase":"marketed","mechanism":"Avapro works by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure.","indications":["Diabetic renal disease","Hypertensive disorder"],"catalyst":""},{"name":"BSI-201","genericName":"BSI-201","slug":"bsi-201","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Bacillus Clausii Multi ATB Resist","genericName":"Bacillus Clausii Multi ATB Resist","slug":"bacillus-clausii-multi-atb-resist","phase":"marketed","mechanism":"Bacillus clausii is a spore-forming probiotic bacterium that restores and maintains healthy gut microbiota, particularly in cases of antibiotic-associated dysbiosis.","indications":["Prevention and treatment of antibiotic-associated diarrhea","Restoration of intestinal microbiota balance during antibiotic therapy"],"catalyst":""},{"name":"Bevacizumab and trastuzumab maintenance therapy","genericName":"Bevacizumab and trastuzumab maintenance therapy","slug":"bevacizumab-and-trastuzumab-maintenance-therapy","phase":"phase_2","mechanism":"Inhibits vascular endothelial growth factor A (VEGFA) and human epidermal growth factor receptor 2 (HER2)","indications":["Breast cancer","Non-small cell lung cancer"],"catalyst":""},{"name":"Bevacizumab maintenance therapy","genericName":"Bevacizumab maintenance therapy","slug":"bevacizumab-maintenance-therapy","phase":"phase_2","mechanism":"Inhibits vascular endothelial growth factor A (VEGF-A)","indications":["Colorectal cancer","Breast cancer","Non-small cell lung cancer"],"catalyst":""},{"name":"Blood draw for the laboratory assessment","genericName":"Blood draw for the laboratory assessment","slug":"blood-draw-for-the-laboratory-assessment","phase":"phase_2","mechanism":"Blood draw for laboratory assessment involves the collection of blood samples for diagnostic testing.","indications":["Laboratory assessment"],"catalyst":""},{"name":"Cabazitaxel (XRP6258)","genericName":"Cabazitaxel (XRP6258)","slug":"cabazitaxel-xrp6258","phase":"marketed","mechanism":"Cabazitaxel is a microtubule-stabilizing taxane that binds to β-tubulin and prevents microtubule depolymerization, leading to cell cycle arrest and apoptosis in cancer cells.","indications":["Metastatic castration-resistant prostate cancer (mCRPC) in patients previously treated with docetaxel","Metastatic breast cancer in patients previously treated with taxanes"],"catalyst":""},{"name":"Calcium & Vitamine D3","genericName":"Calcium & Vitamine D3","slug":"calcium-vitamine-d3","phase":"marketed","mechanism":"Calcium and Vitamin D3 work together to promote bone mineralization and maintain serum calcium levels by enhancing intestinal calcium absorption and regulating calcium-phosphate homeostasis.","indications":["Calcium and vitamin D3 deficiency","Osteoporosis prevention and treatment","Hypoparathyroidism","Vitamin D deficiency"],"catalyst":""},{"name":"Calcium and Magnesium","genericName":"Calcium and Magnesium","slug":"calcium-and-magnesium","phase":"marketed","mechanism":"Calcium and magnesium are essential mineral supplements that replenish electrolyte levels and support cellular function, muscle contraction, and nerve transmission.","indications":["Calcium and magnesium deficiency","Osteoporosis prevention and treatment","Muscle cramps and spasms","Cardiovascular support"],"catalyst":""},{"name":"Cantil","genericName":"MEPENZOLATE","slug":"mepenzolate","phase":"marketed","mechanism":"Muscarinic acetylcholine receptor M2","indications":["Gastric ulcer","Peptic ulcer"],"catalyst":""},{"name":"Caprelsa","genericName":"VANDETANIB","slug":"vandetanib","phase":"marketed","mechanism":"Caprelsa works by blocking a specific protein that helps cancer cells grow and spread.","indications":["Carcinoma of thyroid","Medullary thyroid carcinoma"],"catalyst":""},{"name":"Cartonic","genericName":"amrinone","slug":"amrinone","phase":"marketed","mechanism":"cGMP-inhibited 3',5'-cyclic phosphodiesterase A","indications":["Decompensated cardiac failure"],"catalyst":""},{"name":"Ceredase","genericName":"ALGLUCERASE","slug":"alglucerase","phase":"marketed","mechanism":"Enzyme","indications":["Chronic non-neuropathic Gaucher's disease"],"catalyst":""},{"name":"Cerezyme® / Imiglucerase","genericName":"Cerezyme® / Imiglucerase","slug":"cerezyme-imiglucerase","phase":"marketed","mechanism":"Imiglucerase is a recombinant glucocerebrosidase enzyme that breaks down glucocerebroside, a lipid that accumulates in Gaucher disease.","indications":["Gaucher disease type 1","Gaucher disease type 3"],"catalyst":""},{"name":"Charcoal","genericName":"Charcoal","slug":"charcoal","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ChimeriVax-JE, Japanese Encephalitis vaccine","genericName":"ChimeriVax-JE, Japanese Encephalitis vaccine","slug":"chimerivax-je-japanese-encephalitis-vaccine","phase":"phase_3","mechanism":"ChimeriVax-JE is a live attenuated chimeric vaccine that uses a yellow fever virus backbone expressing Japanese encephalitis virus envelope proteins to induce protective immunity against Japanese encephalitis.","indications":["Japanese encephalitis prevention in endemic and at-risk populations"],"catalyst":""},{"name":"ChimeriVax™-JE","genericName":"ChimeriVax™-JE","slug":"chimerivax-je","phase":"phase_3","mechanism":"ChimeriVax-JE is a live attenuated chimeric vaccine that combines the yellow fever vaccine backbone with Japanese encephalitis virus envelope genes to induce protective immunity against Japanese encephalitis.","indications":["Japanese encephalitis prevention in endemic regions"],"catalyst":""},{"name":"Chlamydia mRNA Vaccine","genericName":"Chlamydia mRNA Vaccine","slug":"chlamydia-mrna-vaccine","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Ciclesonide (XRP1526)","genericName":"Ciclesonide (XRP1526)","slug":"ciclesonide-xrp1526","phase":"phase_3","mechanism":"Ciclesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors in lung tissue.","indications":["Asthma (maintenance therapy)","Chronic obstructive pulmonary disease (COPD)"],"catalyst":""},{"name":"Claritin®","genericName":"Claritin®","slug":"claritin","phase":"marketed","mechanism":"Claritin blocks histamine H1 receptors on cells, preventing histamine-mediated allergic responses.","indications":["Allergic rhinitis (seasonal and perennial)","Chronic idiopathic urticaria"],"catalyst":""},{"name":"Clolar","genericName":"CLOFARABINE","slug":"clofarabine","phase":"marketed","mechanism":"Clolar works by inhibiting the enzyme responsible for DNA synthesis, thereby preventing cancer cells from reproducing.","indications":["Acute lymphoid leukemia"],"catalyst":""},{"name":"Clomid","genericName":"clomifene","slug":"clomifene","phase":"marketed","mechanism":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase","indications":["Controlled ovarian stimulation","Female infertility","Induction of spermatogenesis","Ovulation induction"],"catalyst":""},{"name":"Clopidogrel (SR25990)","genericName":"Clopidogrel (SR25990)","slug":"clopidogrel-sr25990","phase":"phase_3","mechanism":"Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits ADP-induced platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.","indications":["Acute coronary syndrome (unstable angina, NSTEMI, STEMI)","Secondary prevention of atherothrombotic events in patients with established cardiovascular disease","Stroke prevention in patients with recent ischemic stroke or transient ischemic attack"],"catalyst":""},{"name":"Clostridium difficile vaccine","genericName":"Clostridium difficile vaccine","slug":"clostridium-difficile-vaccine","phase":"phase_3","mechanism":"This vaccine stimulates the immune system to produce antibodies and cellular immunity against Clostridium difficile toxins and bacterial antigens to prevent infection and disease.","indications":["Prevention of Clostridium difficile infection (CDI)","Prevention of recurrent Clostridium difficile infection"],"catalyst":""},{"name":"Coarsucam","genericName":"Coarsucam","slug":"coarsucam","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"DOCETAXEL(XRP6976) + MODAFINIL","genericName":"DOCETAXEL(XRP6976) + MODAFINIL","slug":"docetaxel-xrp6976-modafinil","phase":"phase_3","mechanism":"Docetaxel stabilizes microtubules to inhibit cancer cell division, while modafinil enhances wakefulness and may improve treatment tolerability and cognitive function during chemotherapy.","indications":["Advanced or metastatic solid tumors (Phase 3 investigational)","Cancer-related fatigue and cognitive impairment during chemotherapy"],"catalyst":""},{"name":"DTaP vaccine","genericName":"DTaP vaccine","slug":"dtap-vaccine","phase":"phase_3","mechanism":"DTaP vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria toxin, tetanus toxin, and pertussis antigens.","indications":["Prevention of diphtheria in infants and children","Prevention of tetanus in infants and children","Prevention of pertussis (whooping cough) in infants and children"],"catalyst":""},{"name":"DTaP-IPV combined vaccine","genericName":"DTaP-IPV combined vaccine","slug":"dtap-ipv-combined-vaccine","phase":"phase_3","mechanism":"This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and poliovirus by delivering inactivated toxins and viral antigens.","indications":["Prevention of diphtheria in infants and children","Prevention of tetanus in infants and children","Prevention of pertussis (whooping cough) in infants and children","Prevention of poliomyelitis in infants and children"],"catalyst":""},{"name":"DTaP-IPV//PRP~T combined vaccine","genericName":"DTaP-IPV//PRP~T combined vaccine","slug":"dtap-ipv-prp-t-combined-vaccine","phase":"phase_3","mechanism":"This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b.","indications":["Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children"],"catalyst":""},{"name":"DTaP//PRP-T Combined Vaccine","genericName":"DTaP//PRP-T Combined Vaccine","slug":"dtap-prp-t-combined-vaccine","phase":"phase_3","mechanism":"This combined vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and Haemophilus influenzae type b (Hib) by presenting inactivated toxoids and conjugated polysaccharide antigens.","indications":["Prevention of diphtheria, tetanus, pertussis, and Haemophilus influenzae type b infection in infants and children"],"catalyst":""},{"name":"DTacP-IPV combined vaccine (TETRAXIM™)","genericName":"DTacP-IPV combined vaccine (TETRAXIM™)","slug":"dtacp-ipv-combined-vaccine-tetraxim","phase":"marketed","mechanism":"Diphtheria toxin, tetanus toxin, Bordetella pertussis antigens (PT, FHA, PRN), poliovirus types 1, 2, and 3","indications":["Prevention of diphtheria, tetanus, pertussis, and poliomyelitis in children 6 weeks through 6 years of age"],"catalyst":""},{"name":"Dermacid Silver (Lactic acid)","genericName":"Dermacid Silver (Lactic acid)","slug":"dermacid-silver-lactic-acid","phase":"phase_3","mechanism":"Lactic acid works as a topical antimicrobial and keratolytic agent that reduces bacterial colonization and promotes skin healing through acidification and exfoliation.","indications":["Infected or colonized wounds","Diabetic foot ulcers","Chronic wounds with bacterial burden"],"catalyst":""},{"name":"Dexchlorpheniramine or Diphenhydramine","genericName":"Dexchlorpheniramine or Diphenhydramine","slug":"dexchlorpheniramine-or-diphenhydramine","phase":"marketed","mechanism":"Blocks histamine H1 receptors to reduce allergic and inflammatory responses.","indications":["Allergic rhinitis","Urticaria and pruritus","Allergic reactions","Motion sickness (diphenhydramine)","Sleep aid (diphenhydramine)"],"catalyst":""},{"name":"Docetaxel (XRP6976)","genericName":"Docetaxel (XRP6976)","slug":"docetaxel-xrp6976","phase":"phase_3","mechanism":"Docetaxel stabilizes microtubules by binding to β-tubulin, preventing their depolymerization and causing cell cycle arrest and apoptosis in rapidly dividing cancer cells.","indications":["Metastatic breast cancer","Non-small cell lung cancer","Prostate cancer","Gastric cancer","Head and neck cancer"],"catalyst":""},{"name":"Doxorubicine + docetaxel sequential","genericName":"Doxorubicine + docetaxel sequential","slug":"doxorubicine-docetaxel-sequential","phase":"phase_3","mechanism":"A sequential chemotherapy regimen combining doxorubicin (an anthracycline topoisomerase II inhibitor) followed by docetaxel (a taxane microtubule stabilizer) to maximize cytotoxic effects against cancer cells.","indications":["Breast cancer (early-stage and metastatic)","Potentially other solid tumors in phase 3 evaluation"],"catalyst":""},{"name":"Dupilumab (SAR231893)","genericName":"Dupilumab (SAR231893)","slug":"dupilumab-sar231893","phase":"marketed","mechanism":"Dupilumab is a monoclonal antibody that blocks the IL-4 receptor alpha subunit, inhibiting signaling of interleukin-4 and interleukin-13, key drivers of type 2 inflammation.","indications":["Moderate-to-severe atopic dermatitis","Moderate-to-severe asthma with type 2 inflammation","Chronic rhinosinusitis with nasal polyps","Eosinophilic esophagitis","Eosinophilic gastroenteritis"],"catalyst":""},{"name":"Dupilumab (SAR231893/REGN668)","genericName":"Dupilumab (SAR231893/REGN668)","slug":"dupilumab-sar231893-regn668","phase":"phase_3","mechanism":"Dupilumab is a monoclonal antibody that blocks the IL-4 receptor alpha subunit, inhibiting signaling of IL-4 and IL-13 cytokines involved in type 2 inflammation.","indications":["Moderate-to-severe atopic dermatitis","Moderate-to-severe asthma (particularly type 2/eosinophilic)","Chronic rhinosinusitis with nasal polyps","Eosinophilic esophagitis"],"catalyst":""},{"name":"Efanesoctocog Alfa BIVV001","genericName":"Efanesoctocog Alfa BIVV001","slug":"efanesoctocog-alfa-bivv001","phase":"phase_3","mechanism":"Efanesoctocog alfa (BIVV001) is a bispecific antibody that bridges Factor IX and Factor X to restore the intrinsic tenase complex activity in hemophilia A patients lacking functional Factor VIII.","indications":["Hemophilia A (with or without Factor VIII inhibitors)"],"catalyst":""},{"name":"Efluelda® Pre-filled syringe","genericName":"Efluelda® Pre-filled syringe","slug":"efluelda-pre-filled-syringe","phase":"phase_2","mechanism":"Efluelda is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of the natural hormone GLP-1 to regulate blood sugar levels.","indications":["Type 2 diabetes"],"catalyst":""},{"name":"Eliglustat GZ385660","genericName":"Eliglustat GZ385660","slug":"eliglustat-gz385660","phase":"phase_3","mechanism":"Eliglustat is a glucosylceramide synthase (GCS) inhibitor that reduces the production of glucosylceramide, a lipid that accumulates in Gaucher disease.","indications":["Gaucher disease type 1"],"catalyst":""},{"name":"Emollient (moisturizer)","genericName":"Emollient (moisturizer)","slug":"emollient-moisturizer","phase":"phase_3","mechanism":"An emollient moisturizer works by forming an occlusive barrier on the skin surface to reduce transepidermal water loss and restore skin hydration.","indications":["Dry skin conditions","Xerosis","Skin barrier dysfunction"],"catalyst":""},{"name":"Enoxaparin sodium (XRP4563)","genericName":"Enoxaparin sodium (XRP4563)","slug":"enoxaparin-sodium-xrp4563","phase":"phase_3","mechanism":"Enoxaparin sodium is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factors Xa and IIa.","indications":["Thromboembolism prophylaxis in surgical patients","Treatment of deep vein thrombosis and pulmonary embolism","Acute coronary syndrome","Prevention of thromboembolic complications in atrial fibrillation"],"catalyst":""},{"name":"Epilim","genericName":"sodium valproate","slug":"sodium valproate","phase":"marketed","mechanism":"Alcohol dehydrogenase [NADP(+)], Histone deacetylase 1, Histone deacetylase 2","indications":["Absence seizure","Bipolar affective disorder, current episode manic","Epilepsy","Epilepsy characterized by intractable complex partial seizures","Migraine Prevention"],"catalyst":""},{"name":"Eplivanserin (SR46349)","genericName":"Eplivanserin (SR46349)","slug":"eplivanserin-sr46349","phase":"phase_3","mechanism":"Eplivanserin is a selective serotonin 5-HT2A receptor antagonist that modulates serotonergic signaling to treat sexual dysfunction.","indications":["Hypoactive sexual desire disorder (HSDD) in premenopausal women"],"catalyst":""},{"name":"Ezalutamide","genericName":"Ezalutamide","slug":"ezalutamide","phase":"discontinued","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"FDC KETOPROFEN+OMEPRAZOLE","genericName":"FDC KETOPROFEN+OMEPRAZOLE","slug":"fdc-ketoprofen-omeprazole","phase":"phase_3","mechanism":"This fixed-dose combination reduces pain and inflammation via ketoprofen (NSAID) while protecting the stomach lining via omeprazole (proton pump inhibitor).","indications":["Chronic pain conditions requiring NSAID therapy with gastric protection","Osteoarthritis or rheumatoid arthritis with high GI ulcer risk"],"catalyst":""},{"name":"FEX60/PE10","genericName":"FEX60/PE10","slug":"fex60-pe10","phase":"phase_3","mechanism":"FEX60/PE10 is a fixed-dose combination of fexofenadine (a selective H1-receptor antagonist) and pseudoephedrine (a sympathomimetic decongestant) that reduces allergic symptoms and nasal congestion.","indications":["Allergic rhinitis with nasal congestion"],"catalyst":""},{"name":"Fexinidazole","genericName":"FEXINIDAZOLE","slug":"fexinidazole","phase":"marketed","mechanism":"Fexinidazole works by releasing free radicals that damage the DNA of Trypanosoma brucei gambiense, ultimately killing the parasite.","indications":["Human African Trypanosomiasis (HAT)","Severe Second Stage HAT"],"catalyst":""},{"name":"Fexofenadine HCI","genericName":"Fexofenadine HCI","slug":"fexofenadine-hci","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Fexofenadine HCL and pseudoephedrine HCL","genericName":"Fexofenadine HCL and pseudoephedrine HCL","slug":"fexofenadine-hcl-and-pseudoephedrine-hcl","phase":"marketed","mechanism":"Fexofenadine blocks histamine H1 receptors to reduce allergy symptoms, while pseudoephedrine acts as a nasal decongestant by stimulating alpha-adrenergic receptors.","indications":["Allergic rhinitis with nasal congestion","Seasonal and perennial allergic rhinitis"],"catalyst":""},{"name":"Fexofenadine, Comparator = Montelukast","genericName":"Fexofenadine, Comparator = Montelukast","slug":"fexofenadine-comparator-montelukast","phase":"phase_3","mechanism":"Fexofenadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without crossing the blood-brain barrier.","indications":["Allergic rhinitis (seasonal and perennial)","Chronic urticaria"],"catalyst":""},{"name":"GEMIGLIPTIN LS15-0444","genericName":"GEMIGLIPTIN LS15-0444","slug":"gemigliptin-ls15-0444","phase":"phase_3","mechanism":"Gemigliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases levels of incretin hormones to stimulate insulin secretion in response to glucose.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"GLIMEPIRIDE + METFORMIN","genericName":"GLIMEPIRIDE + METFORMIN","slug":"glimepiride-metformin","phase":"marketed","mechanism":"Glimepiride stimulates pancreatic insulin secretion while metformin reduces hepatic glucose production and improves insulin sensitivity, together lowering blood glucose in type 2 diabetes.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Gaviscon","genericName":"ALGELDRATE","slug":"algeldrate","phase":"marketed","mechanism":"Small molecule","indications":["Duodenal ulcer disease","Gastric Hypersecretory Conditions","Gastric ulcer","Gastroesophageal reflux disease","Heartburn"],"catalyst":""},{"name":"Gaviscon","genericName":"MAGNESIUM SILICATE","slug":"magnesium-silicate","phase":"marketed","mechanism":"","indications":["Heartburn","Acid Indigestion","Sour Stomach","Upset Stomach"],"catalyst":""},{"name":"Gaviscon","genericName":"Gaviscon","slug":"gaviscon","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Gemcitabine cisplatin followed by docetaxel","genericName":"Gemcitabine cisplatin followed by docetaxel","slug":"gemcitabine-cisplatin-followed-by-docetaxel","phase":"phase_2","mechanism":"Gemcitabine is a nucleoside analog that inhibits DNA synthesis, while cisplatin is a platinum-based alkylating agent that cross-links DNA, and docetaxel is a taxane that stabilizes microtubules.","indications":["Non-small cell lung cancer","Ovarian cancer","Pancreatic cancer"],"catalyst":""},{"name":"Gla-100 (insulin glargine)","genericName":"Gla-100 (insulin glargine)","slug":"gla-100-insulin-glargine","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Glimepiride (HOE490)","genericName":"Glimepiride (HOE490)","slug":"glimepiride-hoe490","phase":"marketed","mechanism":"Glimepiride stimulates insulin secretion from pancreatic beta cells by binding to sulfonylurea receptors on the cell membrane.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Glimiperide","genericName":"Glimiperide","slug":"glimiperide","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Glucoferron","genericName":"FERROUS GLUCONATE","slug":"ferrous-gluconate","phase":"marketed","mechanism":"Small molecule","indications":["Prenatal and Postnatal Folic Acid Supplementation"],"catalyst":""},{"name":"Glycerine Vegetal Soap Granado Traditional","genericName":"Glycerine Vegetal Soap Granado Traditional","slug":"glycerine-vegetal-soap-granado-traditional","phase":"phase_3","mechanism":"This is a topical cleansing soap product containing vegetable glycerin that moisturizes and cleanses skin.","indications":["General skin cleansing and hygiene"],"catalyst":""},{"name":"HOE140 Icatibant","genericName":"HOE140 Icatibant","slug":"hoe140-icatibant","phase":"phase_2","mechanism":"Icatibant is a selective bradykinin B2 receptor antagonist that blocks the inflammatory effects of bradykinin, a key mediator of angioedema.","indications":["Hereditary angioedema (HAE) acute attack treatment","Angioedema prevention in HAE patients"],"catalyst":""},{"name":"HUMAN INSULIN (BIOSYNTHETIC)","genericName":"HUMAN INSULIN (BIOSYNTHETIC)","slug":"human-insulin-biosynthetic","phase":"phase_3","mechanism":"Human insulin (biosynthetic) replaces or supplements the body's own insulin to regulate blood glucose by promoting glucose uptake into cells and storage as glycogen.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus (insulin-dependent)"],"catalyst":""},{"name":"Hexyon vaccine","genericName":"Hexyon vaccine","slug":"hexyon-vaccine","phase":"phase_3","mechanism":"Hexyon is a hexavalent vaccine that provides immunization against six infectious diseases by stimulating the immune system to produce antibodies against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b.","indications":["Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b in infants and children"],"catalyst":""},{"name":"Hualan TIV","genericName":"Hualan TIV","slug":"hualan-tiv","phase":"marketed","mechanism":"Hualan TIV is a trivalent inactivated influenza vaccine that stimulates the immune system to produce antibodies against three strains of influenza virus.","indications":["Seasonal influenza prevention in adults and children"],"catalyst":""},{"name":"Humulin L","genericName":"Humulin L","slug":"humulin-l","phase":"phase_3","mechanism":"Humulin L is a long-acting insulin that binds to insulin receptors to facilitate glucose uptake and utilization in peripheral tissues.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Hyalgan (sodium hyaluronate)","genericName":"Hyalgan (sodium hyaluronate)","slug":"hyalgan-sodium-hyaluronate","phase":"marketed","mechanism":"Sodium hyaluronate is a viscoelastic substance that lubricates and cushions joints by mimicking the properties of natural synovial fluid.","indications":["Osteoarthritis of the knee"],"catalyst":""},{"name":"INSULIN GLARGINE HOE 901","genericName":"INSULIN GLARGINE HOE 901","slug":"insulin-glargine-hoe-901","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and lower blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"INSULIN GLULISINE (HMR1964)","genericName":"INSULIN GLULISINE (HMR1964)","slug":"insulin-glulisine-hmr1964","phase":"marketed","mechanism":"Insulin glulisine is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Imiglucerase GZ437843","genericName":"Imiglucerase GZ437843","slug":"imiglucerase-gz437843","phase":"phase_3","mechanism":"Imiglucerase is a recombinant glucocerebrosidase enzyme that breaks down glucocerebroside, a lipid that accumulates in Gaucher disease.","indications":["Gaucher disease type 1","Gaucher disease type 3"],"catalyst":""},{"name":"Indion","genericName":"PHENINDIONE","slug":"phenindione","phase":"marketed","mechanism":"Prothrombin, Vitamin K epoxide reductase complex subunit 1, Arachidonate 5-lipoxygenase","indications":[],"catalyst":""},{"name":"Inhaled Long-Acting Beta Agonist","genericName":"Inhaled Long-Acting Beta Agonist","slug":"inhaled-long-acting-beta-agonist","phase":"phase_3","mechanism":"Long-acting beta-2 agonists bind to beta-2 adrenergic receptors on airway smooth muscle, causing relaxation and bronchodilation with sustained effect over 12-24 hours.","indications":["Chronic obstructive pulmonary disease (COPD) maintenance therapy","Asthma maintenance therapy"],"catalyst":""},{"name":"Inhaled Long-Acting Muscarinic Antagonist","genericName":"Inhaled Long-Acting Muscarinic Antagonist","slug":"inhaled-long-acting-muscarinic-antagonist","phase":"phase_3","mechanism":"Blocks muscarinic acetylcholine receptors in the airways to reduce bronchoconstriction and mucus secretion in chronic respiratory diseases.","indications":["Chronic obstructive pulmonary disease (COPD)","Asthma (as add-on therapy)"],"catalyst":""},{"name":"Iniparib (SAR240550/BSI-201)","genericName":"Iniparib (SAR240550/BSI-201)","slug":"iniparib-sar240550-bsi-201","phase":"phase_3","mechanism":"Iniparib inhibits poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair, thereby sensitizing cancer cells to chemotherapy and radiation.","indications":["Metastatic triple-negative breast cancer (in combination with chemotherapy)","BRCA-mutant cancers"],"catalyst":""},{"name":"Insulin aspart SAR341402","genericName":"Insulin aspart SAR341402","slug":"insulin-aspart-sar341402","phase":"phase_3","mechanism":"Insulin aspart SAR341402 is a rapid-acting insulin analog that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin degludec 100 U/mL","genericName":"Insulin degludec 100 U/mL","slug":"insulin-degludec-100-u-ml","phase":"marketed","mechanism":"Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin degludec, 100U/ml","genericName":"Insulin degludec, 100U/ml","slug":"insulin-degludec-100u-ml","phase":"marketed","mechanism":"Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine (HOE901)","genericName":"Insulin glargine (HOE901)","slug":"insulin-glargine-hoe901","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine (LANTUS)","genericName":"Insulin glargine (LANTUS)","slug":"insulin-glargine-lantus","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine (U300)","genericName":"Insulin glargine (U300)","slug":"insulin-glargine-u300","phase":"marketed","mechanism":"Insulin glargine (U300) is a long-acting basal insulin that binds to insulin receptors on muscle and fat cells to promote glucose uptake and reduce blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine 300 U/ml","genericName":"Insulin glargine 300 U/ml","slug":"insulin-glargine-300-u-ml","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine U100 (HOE901)","genericName":"Insulin glargine U100 (HOE901)","slug":"insulin-glargine-u100-hoe901","phase":"phase_3","mechanism":"Insulin glargine is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine, 100 U/ml","genericName":"Insulin glargine, 100 U/ml","slug":"insulin-glargine-100-u-ml","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization while suppressing hepatic glucose production.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine, 300U/mL","genericName":"Insulin glargine, 300U/mL","slug":"insulin-glargine-300u-ml","phase":"marketed","mechanism":"Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glargine/Lixisenatide","genericName":"Insulin glargine/Lixisenatide","slug":"insulin-glargine-lixisenatide","phase":"marketed","mechanism":"This fixed-dose combination provides basal insulin coverage via insulin glargine while lixisenatide, a GLP-1 receptor agonist, enhances glucose-dependent insulin secretion and reduces appetite.","indications":["Type 2 diabetes mellitus (as add-on to oral antidiabetic agents or as basal-bolus therapy)"],"catalyst":""},{"name":"Insulin glulisine QD","genericName":"Insulin glulisine QD","slug":"insulin-glulisine-qd","phase":"phase_3","mechanism":"Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to facilitate glucose uptake and lower blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin glulisine TID","genericName":"Insulin glulisine TID","slug":"insulin-glulisine-tid","phase":"phase_3","mechanism":"Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to facilitate glucose uptake and lower blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insulin human/Novolin® 30R","genericName":"Insulin human/Novolin® 30R","slug":"insulin-human-novolin-30r","phase":"phase_3","mechanism":"Insulin human binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insuline Glulisine","genericName":"Insuline Glulisine","slug":"insuline-glulisine","phase":"phase_3","mechanism":"Insulin glulisine is a rapid-acting insulin analog that binds to insulin receptors on muscle and fat cells to promote glucose uptake and lower blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Insuline glargine","genericName":"Insuline glargine","slug":"insuline-glargine","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Insuplant","genericName":"Insuplant","slug":"insuplant","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Irbesartan (Aprovel)","genericName":"Irbesartan (Aprovel)","slug":"irbesartan-aprovel","phase":"marketed","mechanism":"Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release to lower blood pressure.","indications":["Hypertension","Diabetic nephropathy in patients with type 2 diabetes and hypertension"],"catalyst":""},{"name":"Irbesartan - Hydrochlorothiazide","genericName":"Irbesartan - Hydrochlorothiazide","slug":"irbesartan-hydrochlorothiazide","phase":"marketed","mechanism":"Irbesartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume.","indications":["Hypertension","Hypertension in patients with type 2 diabetes mellitus"],"catalyst":""},{"name":"Irbesartan SR47436","genericName":"Irbesartan SR47436","slug":"irbesartan-sr47436","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Irbesartan/atorvastatin fixed dose combination","genericName":"Irbesartan/atorvastatin fixed dose combination","slug":"irbesartan-atorvastatin-fixed-dose-combination","phase":"marketed","mechanism":"This fixed-dose combination lowers blood pressure by blocking angiotensin II receptors while simultaneously reducing cholesterol by inhibiting HMG-CoA reductase.","indications":["Hypertension with dyslipidemia in patients requiring both agents","Cardiovascular risk reduction in hypertensive patients with elevated cholesterol"],"catalyst":""},{"name":"Isatuximab IV","genericName":"Isatuximab IV","slug":"isatuximab-iv","phase":"phase_3","mechanism":"Isatuximab is a monoclonal antibody that binds to CD38 on the surface of multiple myeloma cells, triggering their destruction through multiple immune mechanisms.","indications":["Multiple myeloma (in combination with pomalidomide and dexamethasone)","Multiple myeloma (in combination with carfilzomib and dexamethasone)"],"catalyst":""},{"name":"Itepekimab (SAR440340)","genericName":"Itepekimab (SAR440340)","slug":"itepekimab-sar440340","phase":"phase_3","mechanism":"Itepekimab is a monoclonal antibody that blocks IL-11 signaling to reduce fibrosis and inflammation.","indications":["Idiopathic pulmonary fibrosis (IPF)","Systemic sclerosis-associated interstitial lung disease (SSc-ILD)"],"catalyst":""},{"name":"JE-VAX®","genericName":"JE-VAX®","slug":"je-vax","phase":"phase_3","mechanism":"JE-VAX is a live attenuated vaccine that stimulates immune response against Japanese encephalitis virus.","indications":["Prevention of Japanese encephalitis in endemic regions"],"catalyst":""},{"name":"KETOPROFEN(RP19583)","genericName":"KETOPROFEN(RP19583)","slug":"ketoprofen-rp19583","phase":"phase_3","mechanism":"Ketoprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.","indications":["Acute and chronic pain","Rheumatoid arthritis","Osteoarthritis","Ankylosing spondylitis"],"catalyst":""},{"name":"Ketek","genericName":"TELITHROMYCIN","slug":"telithromycin","phase":"marketed","mechanism":"Potassium voltage-gated channel subfamily H member 2","indications":["Chlamydial pneumonia","Haemophilus influenzae pneumonia","Moraxella Catarrhalis Pneumonia","Pneumococcal pneumonia","Pneumonia due to Mycoplasma pneumoniae"],"catalyst":""},{"name":"LACTIC ACID(ND)","genericName":"LACTIC ACID(ND)","slug":"lactic-acid-nd","phase":"marketed","mechanism":"Lactic acid is a natural metabolite that functions as a pH buffer and metabolic substrate in topical and systemic formulations.","indications":[],"catalyst":""},{"name":"LENOGRASTIM (GRANOGYTE 34)","genericName":"LENOGRASTIM (GRANOGYTE 34)","slug":"lenograstim-granogyte-34","phase":"marketed","mechanism":"Lenograstim is a recombinant human granulocyte colony-stimulating factor (G-CSF) that stimulates the proliferation and differentiation of neutrophil precursor cells in bone marrow.","indications":["Chemotherapy-induced neutropenia","Bone marrow transplantation support","Severe congenital neutropenia","Mobilization of peripheral blood progenitor cells for autologous transplantation"],"catalyst":""},{"name":"Lactic acid (Dermacid)","genericName":"Lactic acid (Dermacid)","slug":"lactic-acid-dermacid","phase":"phase_3","mechanism":"Lactic acid works as a keratolytic and exfoliating agent that dissolves and removes damaged outer skin layers to promote skin renewal and improve texture.","indications":["Ichthyosis and related keratinization disorders","Photoaged skin and hyperpigmentation"],"catalyst":""},{"name":"Lactic acid (Dermacyd Femina)","genericName":"Lactic acid (Dermacyd Femina)","slug":"lactic-acid-dermacyd-femina","phase":"phase_3","mechanism":"Lactic acid maintains vaginal pH and creates an acidic environment that inhibits the growth of pathogenic bacteria and fungi.","indications":["Vaginal hygiene and prevention of vaginal infections","Treatment of vulvovaginal candidiasis","Maintenance of normal vaginal microflora"],"catalyst":""},{"name":"Lactoserum (Dermacyd Femina®)","genericName":"Lactoserum (Dermacyd Femina®)","slug":"lactoserum-dermacyd-femina","phase":"marketed","mechanism":"Lactoserum is a lactic acid-based vaginal cleanser that maintains vaginal pH and supports the natural lactobacillus flora.","indications":["Vaginal hygiene and maintenance of normal vaginal flora","Prevention of vaginal dysbiosis and associated infections"],"catalyst":""},{"name":"Lantus (insulin glargine)","genericName":"Lantus (insulin glargine)","slug":"lantus-insulin-glargine","phase":"phase_3","mechanism":"Lantus is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake into cells and inhibiting hepatic glucose production.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"Lantus, Amaryl","genericName":"Lantus, Amaryl","slug":"lantus-amaryl","phase":"marketed","mechanism":"Lantus is a long-acting basal insulin that lowers blood glucose by promoting glucose uptake and utilization in peripheral tissues and inhibiting hepatic glucose production, while Amaryl is a meglitinide that stimulates pancreatic beta cells to release insulin in response to meals.","indications":["Type 2 diabetes mellitus","Type 1 diabetes mellitus (Lantus)"],"catalyst":""},{"name":"Levalbuterol/Levosalbutamol","genericName":"Levalbuterol/Levosalbutamol","slug":"levalbuterol-levosalbutamol","phase":"phase_3","mechanism":"Levalbuterol is the active R-enantiomer of albuterol that selectively binds to beta-2 adrenergic receptors on airway smooth muscle to cause bronchodilation.","indications":["Acute bronchospasm in patients with reversible obstructive airway disease","Prevention of exercise-induced bronchospasm"],"catalyst":""},{"name":"Levothyroxin-Na","genericName":"Levothyroxin-Na","slug":"levothyroxin-na","phase":"marketed","mechanism":"Levothyroxine sodium is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function.","indications":["Hypothyroidism","Thyroid cancer suppression therapy","Myxedema coma"],"catalyst":""},{"name":"Levothyroxine-Na + iodide","genericName":"Levothyroxine-Na + iodide","slug":"levothyroxine-na-iodide","phase":"marketed","mechanism":"Levothyroxine-Na replaces deficient thyroid hormone to restore normal metabolic function, while iodide provides substrate for thyroid hormone synthesis.","indications":["Hypothyroidism","Iodine deficiency with hypothyroidism"],"catalyst":""},{"name":"Lipid Modifying Therapy (LMT)","genericName":"Lipid Modifying Therapy (LMT)","slug":"lipid-modifying-therapy-lmt","phase":"phase_3","mechanism":"Lipid Modifying Therapy reduces circulating lipid levels through modulation of lipid metabolism pathways to lower cardiovascular risk.","indications":["Hyperlipidemia / dyslipidemia","Cardiovascular disease prevention"],"catalyst":""},{"name":"Lixisenatide (AVE0010)","genericName":"Lixisenatide (AVE0010)","slug":"lixisenatide-ave0010","phase":"marketed","mechanism":"Lixisenatide is a GLP-1 receptor agonist that stimulates insulin secretion and reduces glucagon in response to elevated blood glucose.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Lovenox (Preservative Free)","genericName":"ENOXAPARIN SODIUM","slug":"enoxaparin-sodium","phase":"marketed","mechanism":"Lovenox works by enhancing the activity of antithrombin-III to inhibit blood clotting.","indications":["Deep venous thrombosis","Myocardial infarction","Prevention of clot formation during haemodialysis","Prevention of venous thromboembolism","Pulmonary embolism"],"catalyst":""},{"name":"M-M-R II vaccine","genericName":"M-M-R II vaccine","slug":"m-m-r-ii-vaccine","phase":"phase_3","mechanism":"M-M-R II is a live attenuated vaccine that stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses.","indications":["Prevention of measles, mumps, and rubella in children and adults"],"catalyst":""},{"name":"M-M-RvaxPro vaccine","genericName":"M-M-RvaxPro vaccine","slug":"m-m-rvaxpro-vaccine","phase":"phase_3","mechanism":"M-M-RvaxPro is a recombinant measles and mumps vaccine that stimulates immune responses against measles and mumps viruses through live attenuated viral antigens.","indications":["Prevention of measles","Prevention of mumps"],"catalyst":""},{"name":"MAXOMAT ®, biosynthetic growth hormone","genericName":"MAXOMAT ®, biosynthetic growth hormone","slug":"maxomat-biosynthetic-growth-hormone","phase":"phase_3","mechanism":"MAXOMAT is a biosynthetic human growth hormone that binds to growth hormone receptors to stimulate growth, metabolism, and protein synthesis.","indications":["Growth hormone deficiency in children","Growth hormone deficiency in adults"],"catalyst":""},{"name":"MRI contrast-enhancing preparations","genericName":"MRI contrast-enhancing preparations","slug":"mri-contrast-enhancing-preparations","phase":"phase_3","mechanism":"MRI contrast-enhancing preparations work by accumulating in target tissues and altering local magnetic properties to improve visualization on magnetic resonance imaging scans.","indications":["Enhancement of MRI imaging in diagnostic procedures"],"catalyst":""},{"name":"Mandated back ground therapy","genericName":"Mandated back ground therapy","slug":"mandated-back-ground-therapy","phase":"marketed","mechanism":"Metformin works by decreasing glucose production in the liver, increasing insulin sensitivity, and enhancing glucose uptake in muscles.","indications":["Type 2 diabetes","Polycystic ovary syndrome (PCOS)"],"catalyst":""},{"name":"Measles Mumps and Rubella Vaccine","genericName":"Measles Mumps and Rubella Vaccine","slug":"measles-mumps-and-rubella-vaccine","phase":"marketed","mechanism":"The MMR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses by exposing it to attenuated (weakened) forms of these pathogens.","indications":["Prevention of measles","Prevention of mumps","Prevention of rubella"],"catalyst":""},{"name":"MenAC conjugate vaccine","genericName":"MenAC conjugate vaccine","slug":"menac-conjugate-vaccine","phase":"phase_3","mechanism":"MenAC conjugate vaccine stimulates the immune system to produce antibodies against meningococcal serogroups A and C by conjugating polysaccharide antigens to a protein carrier.","indications":["Prevention of meningococcal disease caused by Neisseria meningitidis serogroups A and C"],"catalyst":""},{"name":"MenACYW135 polysaccharide vaccine","genericName":"MenACYW135 polysaccharide vaccine","slug":"menacyw135-polysaccharide-vaccine","phase":"phase_3","mechanism":"MenACYW135 is a conjugate vaccine that stimulates the immune system to produce antibodies against meningococcal serogroups A, C, W, and Y polysaccharide antigens.","indications":["Prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W, and Y"],"catalyst":""},{"name":"Metformin (Background drug)","genericName":"Metformin (Background drug)","slug":"metformin-background-drug","phase":"phase_3","mechanism":"Metformin reduces hepatic glucose production and improves insulin sensitivity by activating AMP-activated protein kinase (AMPK).","indications":["Type 2 diabetes mellitus","Prediabetes (prevention of progression to type 2 diabetes)","Polycystic ovary syndrome (PCOS)"],"catalyst":""},{"name":"Methylprednisolone or equivalent","genericName":"Methylprednisolone or equivalent","slug":"methylprednisolone-or-equivalent","phase":"marketed","mechanism":"Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)","Allergic reactions and asthma exacerbations","Adrenal insufficiency","Cerebral edema","Multiple sclerosis relapse"],"catalyst":""},{"name":"Metoclopramide, Granisetron, or Ondansetron","genericName":"Metoclopramide, Granisetron, or Ondansetron","slug":"metoclopramide-granisetron-or-ondansetron","phase":"marketed","mechanism":"This is a combination of three distinct antiemetic agents with different mechanisms: metoclopramide blocks dopamine receptors and enhances acetylcholine effects to increase gastric motility, while granisetron and ondansetron are 5-HT3 receptor antagonists that block serotonin signaling in the chemoreceptor trigger zone.","indications":["Chemotherapy-induced nausea and vomiting (CINV)","Postoperative nausea and vomiting (PONV)","Gastroparesis (metoclopramide)","Migraine-associated nausea (metoclopramide)"],"catalyst":""},{"name":"Miacalcin","genericName":"calcitonin (salmon synthetic)","slug":"calcitonin-salmon-synthetic","phase":"marketed","mechanism":"Calcitonin salmon acts as a calcitonin receptor agonist, primarily affecting bone, with additional effects on the kidneys and gastrointestinal tract.","indications":["Hypercalcemia Treatment Adjunct","Osteitis deformans","Postmenopausal osteoporosis"],"catalyst":""},{"name":"Micronase","genericName":"glibenclamide","slug":"glibenclamide","phase":"marketed","mechanism":"Sulfonylurea receptor 1, Kir6.2","indications":["Diabetes mellitus type 2","Neonatal diabetes mellitus"],"catalyst":""},{"name":"Mizollen","genericName":"MIZOLASTINE","slug":"mizolastine","phase":"marketed","mechanism":"Histamine H1 receptor","indications":["Allergic rhinitis","Perennial allergic rhinitis"],"catalyst":""},{"name":"Moisturizers","genericName":"Moisturizers","slug":"moisturizers","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Mometasone furoate 50 micrograms","genericName":"Mometasone furoate 50 micrograms","slug":"mometasone-furoate-50-micrograms","phase":"phase_3","mechanism":"Mometasone furoate is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and reducing the production of inflammatory mediators.","indications":["Allergic rhinitis","Asthma","Chronic obstructive pulmonary disease (COPD)","Inflammatory skin conditions"],"catalyst":""},{"name":"Montelukast or equivalent","genericName":"Montelukast or equivalent","slug":"montelukast-or-equivalent","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Mycophenolate Na","genericName":"Mycophenolate Na","slug":"mycophenolate-na","phase":"marketed","mechanism":"Mycophenolate sodium inhibits inosine monophosphate dehydrogenase (IMPDH), selectively suppressing T and B lymphocyte proliferation to prevent organ rejection.","indications":["Prevention of acute organ rejection in patients receiving allogeneic renal, cardiac, or hepatic transplants","Treatment of active lupus nephritis"],"catalyst":""},{"name":"Mytelase","genericName":"AMBENONIUM","slug":"ambenonium","phase":"marketed","mechanism":"Acetylcholinesterase","indications":["Myasthenia gravis"],"catalyst":""},{"name":"NPH insulin (insulin isophane)","genericName":"NPH insulin (insulin isophane)","slug":"nph-insulin-insulin-isophane","phase":"marketed","mechanism":"NPH insulin binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.","indications":["Type 1 diabetes mellitus","Type 2 diabetes mellitus"],"catalyst":""},{"name":"NVX-CoV2705","genericName":"NVX-CoV2705","slug":"nvx-cov2705","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Neogaa","genericName":"AVALGLUCOSIDASE ALFA","slug":"avalglucosidase-alfa","phase":"marketed","mechanism":"AVALGLUCOSIDASE ALFA breaks down glycogen in lysosomes to treat Pompe disease.","indications":["Late-onset Pompe disease","Pompe disease"],"catalyst":""},{"name":"Nolpitantium besylate","genericName":"Nolpitantium besylate","slug":"nolpitantium-besylate","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Non sedating H1-antihistamine","genericName":"Non sedating H1-antihistamine","slug":"non-sedating-h1-antihistamine","phase":"phase_3","mechanism":"Selectively blocks H1 histamine receptors on mast cells and basophils without crossing the blood-brain barrier, preventing histamine-mediated allergic responses without causing sedation.","indications":["Allergic rhinitis","Chronic urticaria","Allergic conjunctivitis"],"catalyst":""},{"name":"Non-insulin anti-diabetic treatment","genericName":"Non-insulin anti-diabetic treatment","slug":"non-insulin-anti-diabetic-treatment","phase":"marketed","mechanism":"Non-insulin anti-diabetic treatments work through various mechanisms to lower blood glucose by enhancing insulin secretion, improving insulin sensitivity, reducing hepatic glucose production, or slowing carbohydrate absorption.","indications":["Type 2 diabetes mellitus (multiple agents across various classes)"],"catalyst":""},{"name":"Non-insulin antihyperglycemic drugs","genericName":"Non-insulin antihyperglycemic drugs","slug":"non-insulin-antihyperglycemic-drugs","phase":"phase_3","mechanism":"Non-insulin antihyperglycemic drugs lower blood glucose through mechanisms other than insulin replacement, such as enhancing insulin secretion, improving insulin sensitivity, or reducing hepatic glucose production.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Non-statin LMT","genericName":"Non-statin LMT","slug":"non-statin-lmt","phase":"phase_3","mechanism":"Non-statin LMT (lipid-modifying therapy) reduces low-density lipoprotein cholesterol through a mechanism other than HMG-CoA reductase inhibition.","indications":["Dyslipidemia / hypercholesterolemia (specific indication unknown pending phase 3 data)"],"catalyst":""},{"name":"Non-statin Lipid-Modifying Therapy","genericName":"Non-statin Lipid-Modifying Therapy","slug":"non-statin-lipid-modifying-therapy","phase":"phase_3","mechanism":"Non-statin lipid-modifying therapies work through alternative pathways to reduce cholesterol and triglycerides without inhibiting HMG-CoA reductase.","indications":["Hyperlipidemia / dyslipidemia management","Cardiovascular risk reduction in statin-intolerant or inadequately controlled patients"],"catalyst":""},{"name":"NovoLog/NovoRapid","genericName":"NovoLog/NovoRapid","slug":"novolog-novorapid","phase":"phase_3","mechanism":"NovoLog/NovoRapid is a rapid-acting insulin analog that mimics the action of natural insulin to lower blood glucose levels.","indications":["Type 1 diabetes","Type 2 diabetes"],"catalyst":""},{"name":"Ombrabulin (AVE8062)","genericName":"Ombrabulin (AVE8062)","slug":"ombrabulin-ave8062","phase":"phase_3","mechanism":"Ombrabulin is a vascular disrupting agent that binds to tubulin and disrupts microtubule dynamics, causing selective destruction of tumor vasculature and tumor cell death.","indications":["Non-small cell lung cancer (NSCLC)","Ovarian cancer","Other solid tumors"],"catalyst":""},{"name":"Open-label Semuloparin sodium","genericName":"Open-label Semuloparin sodium","slug":"open-label-semuloparin-sodium","phase":"phase_3","mechanism":"Semuloparin sodium is a selective inhibitor of Factor Xa that prevents thrombin generation and blood clot formation.","indications":["Thromboprophylaxis in patients undergoing abdominal surgery","Thromboprophylaxis in patients with acute medical illness"],"catalyst":""},{"name":"Oral Anti Diabetics (OAD)","genericName":"Oral Anti Diabetics (OAD)","slug":"oral-anti-diabetics-oad","phase":"marketed","mechanism":"Oral anti-diabetics are a class of medications that lower blood glucose through various mechanisms including insulin secretion stimulation, insulin sensitivity improvement, or glucose absorption reduction.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Oral Rehydration Therapy","genericName":"Oral Rehydration Therapy","slug":"oral-rehydration-therapy","phase":"marketed","mechanism":"Oral Rehydration Therapy (ORT) replaces lost fluids and electrolytes (sodium, potassium, chloride, glucose) through the small intestine to restore hydration and electrolyte balance.","indications":["Acute diarrhea and dehydration","Cholera","Gastroenteritis","Dehydration from vomiting or other causes"],"catalyst":""},{"name":"Oral anti-diabetic drugs","genericName":"Oral anti-diabetic drugs","slug":"oral-anti-diabetic-drugs","phase":"phase_3","mechanism":"Oral anti-diabetic drugs work by improving blood glucose control through various mechanisms including insulin secretion enhancement, insulin sensitivity improvement, or glucose absorption reduction.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"Osteobios","genericName":"CALCITONIN","slug":"calcitonin","phase":"marketed","mechanism":"Calcitonin salmon acts as a calcitonin receptor agonist, primarily affecting bone, with additional effects on the kidneys and gastrointestinal tract.","indications":["Symptomatic Paget's disease of bone","Hypercalcemia","Postmenopausal osteoporosis"],"catalyst":""},{"name":"PEG-G-CSF","genericName":"PEG-G-CSF","slug":"peg-g-csf","phase":"marketed","mechanism":"PEG-G-CSF is a pegylated granulocyte colony-stimulating factor that stimulates the bone marrow to produce and release neutrophils, reducing the duration and severity of chemotherapy-induced neutropenia.","indications":["Chemotherapy-induced neutropenia in patients with non-myeloid malignancies","Reduction of duration of severe neutropenia in patients receiving myeloablative chemotherapy followed by bone marrow transplantation"],"catalyst":""},{"name":"PRISTINAMYCIN XRP7263","genericName":"PRISTINAMYCIN XRP7263","slug":"pristinamycin-xrp7263","phase":"marketed","mechanism":"Pristinamycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.","indications":["Bacterial infections caused by susceptible gram-positive organisms","Respiratory tract infections","Skin and soft tissue infections"],"catalyst":""},{"name":"Pandemic flu H5 HA mRNA SD2 vaccine","genericName":"Pandemic flu H5 HA mRNA SD2 vaccine","slug":"pandemic-flu-h5-ha-mrna-sd2-vaccine","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Pentacel: DTaP-IPV/Hib","genericName":"Pentacel: DTaP-IPV/Hib","slug":"pentacel-dtap-ipv-hib","phase":"phase_3","mechanism":"Pentacel is a combination vaccine that stimulates the immune system to produce antibodies against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b.","indications":["Active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children"],"catalyst":""},{"name":"Placebo (for Eptifibatide)","genericName":"Placebo (for Eptifibatide)","slug":"placebo-for-eptifibatide","phase":"phase_3","mechanism":"A placebo contains no active pharmaceutical ingredient and produces no pharmacological effect.","indications":["Control arm in Phase 3 clinical trial for Eptifibatide (acute coronary syndrome, percutaneous coronary intervention)"],"catalyst":""},{"name":"Placebo (for Ezetimibe)","genericName":"Placebo (for Ezetimibe)","slug":"placebo-for-ezetimibe","phase":"phase_3","mechanism":"Placebo is an inert substance with no active pharmacological mechanism.","indications":["Control arm in Phase 3 trial for Ezetimibe (cholesterol-lowering agent)"],"catalyst":""},{"name":"Placebo (for Ketoprofen)","genericName":"Placebo (for Ketoprofen)","slug":"placebo-for-ketoprofen","phase":"marketed","mechanism":"A placebo contains no active pharmaceutical ingredients and produces no pharmacological effect, serving as an inert control in clinical trials.","indications":["Clinical trial control for Ketoprofen efficacy studies"],"catalyst":""},{"name":"Placebo (for Otamixaban)","genericName":"Placebo (for Otamixaban)","slug":"placebo-for-otamixaban","phase":"phase_3","mechanism":"Placebo is an inert control substance with no active pharmacological mechanism.","indications":["Control arm in Phase 3 trials for Otamixaban (acute coronary syndrome or related cardiovascular indication)"],"catalyst":""},{"name":"Placebo (for UFH)","genericName":"Placebo (for UFH)","slug":"placebo-for-ufh","phase":"phase_3","mechanism":"This drug has no known mechanism of action as it is a placebo.","indications":["Atrial fibrillation for stroke prevention"],"catalyst":""},{"name":"Placebo (for aflibercept)","genericName":"Placebo (for aflibercept)","slug":"placebo-for-aflibercept","phase":"phase_3","mechanism":"Placebo does not have a known mechanism of action.","indications":["Comparison control in clinical trials for aflibercept"],"catalyst":""},{"name":"Placebo (for alirocumab)","genericName":"Placebo (for alirocumab)","slug":"placebo-for-alirocumab","phase":"phase_3","mechanism":"Placebo does not have a pharmacological effect.","indications":["Hyperlipidemia"],"catalyst":""},{"name":"Placebo (for dronedarone)","genericName":"Placebo (for dronedarone)","slug":"placebo-for-dronedarone","phase":"marketed","mechanism":"Placebo has no active pharmacological mechanism; it is an inert substance used as a control in clinical trials.","indications":["Control arm in clinical trials for dronedarone (atrial fibrillation management)"],"catalyst":""},{"name":"Placebo of Modafinil","genericName":"Placebo of Modafinil","slug":"placebo-of-modafinil","phase":"phase_3","mechanism":"Placebo does not have a known mechanism of action, as it is an inert substance.","indications":["Treatment of narcolepsy, sleep apnea, and shift work sleep disorder"],"catalyst":""},{"name":"Placebo to match Teriflunomide","genericName":"Placebo to match Teriflunomide","slug":"placebo-to-match-teriflunomide","phase":"phase_3","mechanism":"Placebos do not have a known mechanism of action.","indications":[],"catalyst":""},{"name":"Placebo to match Tolebrutinib","genericName":"Placebo to match Tolebrutinib","slug":"placebo-to-match-tolebrutinib","phase":"phase_3","mechanism":"This is a placebo formulation designed to match the appearance, taste, and administration characteristics of Tolebrutinib for blinded clinical trial purposes.","indications":[],"catalyst":""},{"name":"Placlitaxel","genericName":"Placlitaxel","slug":"placlitaxel","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Pneumococcal Vaccine Polyvalent-Pneumovax 23","genericName":"Pneumococcal Vaccine Polyvalent-Pneumovax 23","slug":"pneumococcal-vaccine-polyvalent-pneumovax-23","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Prednisone or Prednisolone","genericName":"Prednisone or Prednisolone","slug":"prednisone-or-prednisolone","phase":"phase_3","mechanism":"Prednisone and prednisolone are corticosteroids that suppress the immune system and reduce inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Adrenocortical insufficiency","Rheumatoid arthritis","Systemic lupus erythematosus","Asthma and chronic obstructive pulmonary disease","Allergic reactions"],"catalyst":""},{"name":"Prevnar 20 vaccine","genericName":"Prevnar 20 vaccine","slug":"prevnar-20-vaccine","phase":"phase_3","mechanism":"Prevnar 20 is a pneumococcal conjugate vaccine that stimulates the immune system to produce antibodies against 20 serotypes of Streptococcus pneumoniae.","indications":["Prevention of invasive pneumococcal disease in adults aged 18 years and older","Prevention of pneumococcal pneumonia in adults aged 18 years and older"],"catalyst":""},{"name":"Priftin","genericName":"RIFAPENTINE","slug":"rifapentine","phase":"marketed","mechanism":"Priftin works by inhibiting the synthesis of mycolic acid, a key component of the Mycobacterium tuberculosis cell wall.","indications":["Pulmonary tuberculosis"],"catalyst":""},{"name":"RAMIPRIL HOE498","genericName":"RAMIPRIL HOE498","slug":"ramipril-hoe498","phase":"marketed","mechanism":"Ramipril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.","indications":["Hypertension","Heart failure","Post-myocardial infarction","Diabetic nephropathy prevention"],"catalyst":""},{"name":"Ramipril + Felodipine","genericName":"Ramipril + Felodipine","slug":"ramipril-felodipine","phase":"marketed","mechanism":"This combination lowers blood pressure by blocking angiotensin II formation (ramipril) and relaxing blood vessel smooth muscle (felodipine).","indications":["Hypertension"],"catalyst":""},{"name":"Rasburicase (SR29142)","genericName":"Rasburicase (SR29142)","slug":"rasburicase-sr29142","phase":"marketed","mechanism":"Rasburicase is a recombinant urate oxidase enzyme that catalyzes the conversion of uric acid to allantoin, a more soluble metabolite that is readily excreted.","indications":["Tumor lysis syndrome prevention and treatment in patients with hematologic malignancies at high risk of rapid cell turnover","Hyperuricemia management in patients receiving chemotherapy"],"catalyst":""},{"name":"Receptal","genericName":"BUSERELIN","slug":"buserelin","phase":"marketed","mechanism":"Gonadotropin-releasing hormone receptor","indications":["Induction of final follicular maturation","Prevention of premature ovulation"],"catalyst":""},{"name":"Renvela","genericName":"SEVELAMER CARBONATE","slug":"sevelamer-carbonate","phase":"marketed","mechanism":"Renvela works by binding to dietary phosphate in the gut, preventing its absorption into the bloodstream.","indications":["Renal Osteodystrophy with Hyperphosphatemia","Renal dialysis"],"catalyst":""},{"name":"Risedronate (HMR4003)","genericName":"Risedronate (HMR4003)","slug":"risedronate-hmr4003","phase":"marketed","mechanism":"Risedronate inhibits bone resorption by binding to hydroxyapatite on bone surfaces and inhibiting osteoclast activity.","indications":["Osteoporosis in postmenopausal women","Osteoporosis in men","Paget's disease of bone","Glucocorticoid-induced osteoporosis"],"catalyst":""},{"name":"Risedronate Sodium (Actonel)","genericName":"Risedronate Sodium (Actonel)","slug":"risedronate-sodium-actonel","phase":"marketed","mechanism":"Risedronate is a bisphosphonate that inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite on the bone surface and blocking farnesyl pyrophosphate synthase in the mevalonate pathway.","indications":["Postmenopausal osteoporosis (treatment and prevention)","Glucocorticoid-induced osteoporosis","Paget's disease of bone","Osteoporosis in men"],"catalyst":""},{"name":"Rosuvastatin active capsule","genericName":"Rosuvastatin active capsule","slug":"rosuvastatin-active-capsule","phase":"phase_3","mechanism":"Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.","indications":["Hypercholesterolemia and dyslipidemia","Primary prevention of cardiovascular disease","Secondary prevention of cardiovascular events in patients with established coronary artery disease"],"catalyst":""},{"name":"Rovamycin","genericName":"SPIRAMYCIN","slug":"spiramycin","phase":"marketed","mechanism":"Small molecule","indications":["Prophylaxis of congenital toxoplasmosis"],"catalyst":""},{"name":"SAR153191 (REGN88)","genericName":"SAR153191 (REGN88)","slug":"sar153191-regn88","phase":"phase_3","mechanism":"SAR153191 is a monoclonal antibody that targets the PD-1 receptor.","indications":["Non-small cell lung cancer","Head and neck squamous cell carcinoma"],"catalyst":""},{"name":"SAR231893","genericName":"SAR231893","slug":"sar231893","phase":"marketed","mechanism":"SAR231893 is a selective androgen receptor modulator (SARM) that activates androgen signaling in a tissue-selective manner.","indications":["Muscle wasting and weakness in aging males","Osteoporosis and bone loss"],"catalyst":""},{"name":"SAR342434","genericName":"SAR342434","slug":"sar342434","phase":"phase_3","mechanism":"SAR342434 is a monoclonal antibody that targets and inhibits APRIL (A PRoliferation-Inducing Ligand) to reduce B cell activation and autoimmune responses.","indications":["Systemic lupus erythematosus (SLE)"],"catalyst":""},{"name":"SAR405838","genericName":"SAR405838","slug":"sar405838","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"SARCLISA","genericName":"ISATUXIMAB-IRFC","slug":"isatuximab-irfc","phase":"marketed","mechanism":"Lymphocyte differentiation antigen CD38","indications":["Multiple myeloma"],"catalyst":""},{"name":"SENNA+CASSIA(Naturetti)","genericName":"SENNA+CASSIA(Naturetti)","slug":"senna-cassia-naturetti","phase":"phase_3","mechanism":"Senna and Cassia are anthraquinone laxatives that stimulate bowel movements by increasing water and electrolyte secretion into the intestinal lumen.","indications":["Constipation"],"catalyst":""},{"name":"SODIUM DIVALPROATE","genericName":"SODIUM DIVALPROATE","slug":"sodium-divalproate","phase":"phase_3","mechanism":"Sodium valproate is a mood stabilizer that works by reducing the activity of certain brain chemicals that cause mania and seizures.","indications":["Epilepsy","Manic episodes associated with bipolar disorder"],"catalyst":""},{"name":"SP Shz TIV","genericName":"SP Shz TIV","slug":"sp-shz-tiv","phase":"marketed","mechanism":"SP Shz TIV is a trivalent inactivated influenza vaccine that stimulates immune responses against three seasonal influenza virus strains.","indications":["Seasonal influenza prevention in adults and children"],"catalyst":""},{"name":"SPC ezetimibe/rosuvastatin","genericName":"SPC ezetimibe/rosuvastatin","slug":"spc-ezetimibe-rosuvastatin","phase":"phase_3","mechanism":"Ezetimibe inhibits the absorption of cholesterol in the small intestine, while rosuvastatin inhibits HMG-CoA reductase to reduce cholesterol production in the liver.","indications":["Hypercholesterolemia","Mixed dyslipidemia"],"catalyst":""},{"name":"SR121463B","genericName":"SR121463B","slug":"sr121463b","phase":"phase_3","mechanism":"SR121463B is a small molecule that acts as a selective and potent inhibitor of the serotonin 5-HT6 receptor.","indications":["Alzheimer's disease"],"catalyst":""},{"name":"SR57746A","genericName":"SR57746A","slug":"sr57746a","phase":"phase_3","mechanism":"SR57746A is a small molecule that targets the SGLT2 receptor.","indications":["Type 2 diabetes"],"catalyst":""},{"name":"SSR591813L (dianicline)","genericName":"SSR591813L (dianicline)","slug":"ssr591813l-dianicline","phase":"phase_3","mechanism":"SSR591813L (dianicline) is a norepinephrine reuptake inhibitor.","indications":["Treatment of attention deficit hyperactivity disorder (ADHD)"],"catalyst":""},{"name":"SanOrg34006","genericName":"SanOrg34006","slug":"sanorg34006","phase":"phase_3","mechanism":"SanOrg34006 is a small molecule that acts as a selective inhibitor of the sodium-activated potassium channel, Nav1.5.","indications":["Atrial fibrillation for stroke prevention"],"catalyst":""},{"name":"Sevelamer Carbonate (GZ419831)","genericName":"Sevelamer Carbonate (GZ419831)","slug":"sevelamer-carbonate-gz419831","phase":"phase_3","mechanism":"Sevelamer carbonate is a phosphate binder that works by binding to phosphate in the gastrointestinal tract and preventing its absorption into the bloodstream.","indications":["Chronic kidney disease, including hyperphosphatemia"],"catalyst":""},{"name":"TAA-AQ, Nasacort® AQ","genericName":"TAA-AQ, Nasacort® AQ","slug":"taa-aq-nasacort-aq","phase":"marketed","mechanism":"Triamcinolone acetonide aqueous suspension is a corticosteroid that reduces inflammation and immune response in the nasal passages.","indications":["Allergic rhinitis","Nasal symptoms associated with seasonal and perennial allergies"],"catalyst":""},{"name":"TOFOGLIFLOZIN CSG452","genericName":"TOFOGLIFLOZIN CSG452","slug":"tofogliflozin-csg452","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"TdcP-IPV vaccine","genericName":"TdcP-IPV vaccine","slug":"tdcp-ipv-vaccine","phase":"phase_3","mechanism":"The TdcP-IPV vaccine works by stimulating an immune response to protect against certain diseases.","indications":["Diphtheria, tetanus, and poliomyelitis prevention"],"catalyst":""},{"name":"Teriflunomide HMR1726","genericName":"Teriflunomide HMR1726","slug":"teriflunomide-hmr1726","phase":"marketed","mechanism":"Teriflunomide inhibits dihydroorotate dehydrogenase, an enzyme required for pyrimidine synthesis, thereby reducing proliferation of activated lymphocytes.","indications":["Relapsing-remitting multiple sclerosis (RRMS)","Secondary progressive multiple sclerosis (SPMS)"],"catalyst":""},{"name":"Thyrogen","genericName":"THYROTROPIN ALFA","slug":"thyrotropin-alfa","phase":"marketed","mechanism":"Thyrotropin receptor","indications":["Meal timing"],"catalyst":""},{"name":"Tolebrutininb","genericName":"Tolebrutininb","slug":"tolebrutininb","phase":"discontinued","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Topical corticosteroids","genericName":"Topical corticosteroids","slug":"topical-corticosteroids","phase":"marketed","mechanism":"Topical corticosteroids suppress local immune and inflammatory responses by binding to glucocorticoid receptors in skin cells.","indications":["Inflammatory skin conditions including eczema, psoriasis, and dermatitis","Pruritus and other allergic skin reactions","Lichen planus and other inflammatory dermatoses"],"catalyst":""},{"name":"Topical tacrolimus or pimecrolimus","genericName":"Topical tacrolimus or pimecrolimus","slug":"topical-tacrolimus-or-pimecrolimus","phase":"phase_3","mechanism":"Topical tacrolimus and pimecrolimus are calcineurin inhibitors that suppress the immune system by blocking the activation of T-lymphocytes.","indications":["Moderate to severe atopic dermatitis"],"catalyst":""},{"name":"Tornalate","genericName":"BITOLTEROL","slug":"bitolterol","phase":"marketed","mechanism":"Beta-2 adrenergic receptor","indications":["Acute exacerbation of asthma","Asthma","Asthma management","Bronchiectasis","Bronchitis"],"catalyst":""},{"name":"Trichlophos","genericName":"TRICLOFOS","slug":"triclofos","phase":"marketed","mechanism":"GABA-A receptor; anion channel","indications":[],"catalyst":""},{"name":"Valproic acid, sodium salt","genericName":"Valproic acid, sodium salt","slug":"valproic-acid-sodium-salt","phase":"marketed","mechanism":"Valproic acid inhibits histone deacetylases and enhances GABA neurotransmission, leading to increased inhibitory signaling in the central nervous system.","indications":["Epilepsy and seizure disorders","Bipolar disorder (acute mania)","Migraine prophylaxis","Investigational use in certain cancers (histone deacetylase inhibition)"],"catalyst":""},{"name":"Varivax vaccine","genericName":"Varivax vaccine","slug":"varivax-vaccine","phase":"phase_3","mechanism":"Varivax is a live attenuated varicella-zoster virus vaccine that stimulates the immune system to produce antibodies and cellular immunity against the virus that causes chickenpox.","indications":["Prevention of varicella (chickenpox) in children and adults","Prevention of herpes zoster (shingles) in adults ≥50 years of age"],"catalyst":""},{"name":"Vaxelis vaccine","genericName":"Vaxelis vaccine","slug":"vaxelis-vaccine","phase":"phase_3","mechanism":"Vaxelis is a combination vaccine that stimulates the immune system to produce antibodies and cellular immunity against multiple infectious diseases simultaneously.","indications":["Active immunization against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, Haemophilus influenzae type b, meningococcal disease (serogroup C), measles, mumps, rubella, and varicella in infants and 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