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Asthma Controller Therapies
Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways.
Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways. Used for Asthma maintenance therapy.
At a glance
| Generic name | Asthma Controller Therapies |
|---|---|
| Sponsor | Sanofi |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Pulmonology |
| Phase | Phase 3 |
Mechanism of action
Asthma controller therapies encompass multiple drug classes designed for long-term maintenance treatment rather than acute symptom relief. These include inhaled corticosteroids that suppress airway inflammation, long-acting beta-2 agonists that relax airway smooth muscle, leukotriene receptor antagonists that block inflammatory mediators, and biologic agents targeting specific immune pathways such as IgE or IL-5. Sanofi's Phase 3 asthma controller program likely involves one or more of these mechanisms to reduce exacerbations and improve lung function.
Approved indications
- Asthma maintenance therapy
Common side effects
- Tremor
- Headache
- Palpitations
- Oral candidiasis (with inhaled corticosteroids)
- Muscle cramps
Key clinical trials
- Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab (PHASE3)
- Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma
- A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese Population
- Aligning With Schools To Help Manage Asthma (Project ASTHMA) (NA)
- Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation (NA)
- Remission in Adults With Mild-to-moderate Asthma in Thailand
- Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes (NA)
- Remission in Adults With Severe Asthma in Thailand
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Asthma Controller Therapies CI brief — competitive landscape report
- Asthma Controller Therapies updates RSS · CI watch RSS
- Sanofi portfolio CI