{"id":"asthma-controller-therapies","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Oral candidiasis (with inhaled corticosteroids)"},{"rate":null,"effect":"Muscle cramps"}]},"_chembl":{"chemblId":"CHEMBL1643772","moleculeType":"Small molecule","molecularWeight":"494.57"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Asthma controller therapies encompass multiple drug classes designed for long-term maintenance treatment rather than acute symptom relief. These include inhaled corticosteroids that suppress airway inflammation, long-acting beta-2 agonists that relax airway smooth muscle, leukotriene receptor antagonists that block inflammatory mediators, and biologic agents targeting specific immune pathways such as IgE or IL-5. Sanofi's Phase 3 asthma controller program likely involves one or more of these mechanisms to reduce exacerbations and improve lung function.","oneSentence":"Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:02:44.495Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma maintenance therapy"}]},"trialDetails":[{"nctId":"NCT07363642","phase":"PHASE3","title":"Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-28","conditions":"Severe Asthma","enrollment":400},{"nctId":"NCT07472283","phase":"","title":"Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma","status":"NOT_YET_RECRUITING","sponsor":"University Children's Hospital Basel","startDate":"2026-04","conditions":"Paediatric Asthma","enrollment":42},{"nctId":"NCT06419413","phase":"","title":"A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese Population","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2024-01-08","conditions":"Asthma","enrollment":355},{"nctId":"NCT03032744","phase":"NA","title":"Aligning With Schools To Help Manage Asthma (Project ASTHMA)","status":"COMPLETED","sponsor":"State University of New York at Buffalo","startDate":"2017-01-17","conditions":"Asthma","enrollment":29},{"nctId":"NCT07396987","phase":"NA","title":"Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation","status":"NOT_YET_RECRUITING","sponsor":"Juan Carlos Cardet","startDate":"2026-02","conditions":"Asthma Attack, Asthma Control, Asthma Exacerbations","enrollment":40},{"nctId":"NCT07351916","phase":"","title":"Remission in Adults With Mild-to-moderate Asthma in Thailand","status":"NOT_YET_RECRUITING","sponsor":"Thammasat University","startDate":"2026-02-01","conditions":"Asthma, Mild-to-moderate Asthma, Asthma Control Level","enrollment":289},{"nctId":"NCT06539312","phase":"NA","title":"Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes","status":"RECRUITING","sponsor":"State University of New York at Buffalo","startDate":"2024-09-27","conditions":"Asthma in Children, Directly Observed Therapy","enrollment":400},{"nctId":"NCT07328035","phase":"","title":"Remission in Adults With Severe Asthma in Thailand","status":"NOT_YET_RECRUITING","sponsor":"Thammasat University","startDate":"2026-01-01","conditions":"Severe Asthma, Asthma Control Level","enrollment":230},{"nctId":"NCT07315555","phase":"NA","title":"Efficacy of Oral Nigella Sativa as Adjuvant Therapy in Children With Moderate Persistent Asthma","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-01-01","conditions":"Community Acquired Pneumonia","enrollment":90},{"nctId":"NCT03560466","phase":"PHASE3","title":"Assessment of the Safety and Efficacy of Dupilumab in Children With Asthma (Liberty Asthma Excursion)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2018-06-21","conditions":"Asthma","enrollment":378},{"nctId":"NCT04228107","phase":"NA","title":"Treatment Phenotypes for Adolescents With Asthma","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2020-11-16","conditions":"Asthma in Children, Adherence, Treatment","enrollment":80},{"nctId":"NCT07052942","phase":"PHASE4","title":"Individualizing Treatment for Asthma in Primary Care (Full Study)","status":"RECRUITING","sponsor":"DARTNet Institute","startDate":"2025-08-01","conditions":"Asthma, Asthma Attack, Asthma Exacerbations","enrollment":3200},{"nctId":"NCT04718389","phase":"PHASE3","title":"A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2021-01-26","conditions":"Asthma","enrollment":1719},{"nctId":"NCT03373045","phase":"","title":"Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2018-02-27","conditions":"Asthma","enrollment":18},{"nctId":"NCT05064579","phase":"","title":"Towards an Algorithmic Approach to Asthma Management: Collaborative Definition of Algorithm Objectives With Families","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-01-18","conditions":"Childhood Asthma","enrollment":307},{"nctId":"NCT04643158","phase":"PHASE2","title":"Efficacy and Safety of Inhaled AZD1402 Administered for Four Weeks in Adults With Asthma on Medium-to-High Dose Inhaled Corticosteroids","status":"TERMINATED","sponsor":"AstraZeneca","startDate":"2021-03-12","conditions":"Asthma","enrollment":72},{"nctId":"NCT07141212","phase":"NA","title":"Effect Of Virtual Reality On Pulmonary Function And Anxiety Levels In Asthmatic Patients","status":"NOT_YET_RECRUITING","sponsor":"October 6 University","startDate":"2025-08-30","conditions":"Asthma","enrollment":40},{"nctId":"NCT01718197","phase":"","title":"Severe Asthma Research Program (SARP)- San Francisco Clinical Site","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2012-11","conditions":"Asthma","enrollment":151},{"nctId":"NCT02103348","phase":"","title":"Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2015-09","conditions":"Asthma","enrollment":25},{"nctId":"NCT04480242","phase":"","title":"Asthma Research in Children and Adolescents","status":"ACTIVE_NOT_RECRUITING","sponsor":"Parc de Salut Mar","startDate":"2017-07-26","conditions":"Persistent Asthma, Asthma in Children, Asthma Exacerbation","enrollment":525},{"nctId":"NCT05757583","phase":"","title":"Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2023-04-05","conditions":"Asthma","enrollment":80},{"nctId":"NCT06902766","phase":"NA","title":"Towards Digital Management of Paediatric Asthma","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-10","conditions":"Pediatric Asthma","enrollment":50},{"nctId":"NCT07025616","phase":"NA","title":"Effects of Buteyko Breathing Exercise in Children With Uncontrolled Asthma","status":"NOT_YET_RECRUITING","sponsor":"Ivan Sofian Wibowo","startDate":"2025-06","conditions":"Breathing Techniques, Asthma Control Level, Asthma in Children","enrollment":74},{"nctId":"NCT06272370","phase":"PHASE4","title":"Individualizing Treatment for Asthma in Primary Care","status":"COMPLETED","sponsor":"DARTNet Institute","startDate":"2024-02-01","conditions":"Asthma, Bronchial Diseases, Respiratory Tract Infections","enrollment":103},{"nctId":"NCT03924635","phase":"PHASE4","title":"An Exploratory Study to Characterise Changes in Airway Inflammation, Symptoms, Lung Function and Reliever Use in Adult Asthma Patients","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2019-08-01","conditions":"Airway Inflammation, Asthma","enrollment":42},{"nctId":"NCT04869384","phase":"PHASE4","title":"Effect of Electronic Monitoring and Feedback on Adherence to Easyhaler Controller Medication in Patients With Asthma","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2021-06-23","conditions":"Asthma","enrollment":158},{"nctId":"NCT03514485","phase":"NA","title":"West Philadelphia Controls Asthma","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2018-05-17","conditions":"Childhood Asthma, Community Health Workers","enrollment":626},{"nctId":"NCT02496468","phase":"","title":"Pediatric Arm of DZL All Age Asthma Cohort","status":"RECRUITING","sponsor":"LMU Klinikum","startDate":"2013-01","conditions":"Asthma, Wheeze, Hypersensitivity","enrollment":1500},{"nctId":"NCT00545324","phase":"PHASE4","title":"First Step With Singulair® Therapy (0476-323)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-09","conditions":"Asthma","enrollment":399},{"nctId":"NCT05120323","phase":"NA","title":"vDOT for Newly Diagnosed Pediatric Asthma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2021-11-03","conditions":"Asthma in Children","enrollment":22},{"nctId":"NCT04942379","phase":"NA","title":"Asthma Link: A Real World Application of School Supervised Asthma Therapy","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2021-08-10","conditions":"Childhood Asthma","enrollment":66},{"nctId":"NCT02953431","phase":"NA","title":"Increased Lung Volume as Controller Therapy for Asthma","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2018-05-07","conditions":"Asthma","enrollment":60},{"nctId":"NCT00545844","phase":"PHASE4","title":"Singulair(R) In Asthma And Allergic Rhinitis (0476-383)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-04-01","conditions":"Asthma","enrollment":313},{"nctId":"NCT05933369","phase":"NA","title":"The Impact of Clinical Pharmacist Intervention on Asthmatic Patient's Outcomes","status":"UNKNOWN","sponsor":"University of Gondar","startDate":"2023-06-27","conditions":"Asthma","enrollment":122},{"nctId":"NCT03620747","phase":"PHASE3","title":"Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in Patients With Asthma (Long-Term Follow-Up)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2018-08-30","conditions":"Asthma","enrollment":393},{"nctId":"NCT04677959","phase":"PHASE4","title":"A 24-Week Treatment Study to Compare Standard of Care Versus the eMDPI DS in Participants 13 Years or Older With Asthma","status":"COMPLETED","sponsor":"Teva Branded Pharmaceutical Products R&D, Inc.","startDate":"2021-02-16","conditions":"Asthma","enrollment":427},{"nctId":"NCT03782532","phase":"PHASE3","title":"Efficacy and Safety Study of Dupilumab in Patients With Persistent Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2019-01-25","conditions":"Asthma","enrollment":486},{"nctId":"NCT04326530","phase":"","title":"Use of a Modern Breath Sampling System (the Pneumopipe® Combined With an Array of E-nose Sensors) for the Prediction of Treatment Response in Persistent Asthmatic Children","status":"UNKNOWN","sponsor":"Istituto per la Ricerca e l'Innovazione Biomedica","startDate":"2023-02-01","conditions":"Asthma in Children","enrollment":150},{"nctId":"NCT02225392","phase":"NA","title":"Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2014-04","conditions":"Asthma, Bronchial Asthma","enrollment":40},{"nctId":"NCT04193150","phase":"","title":"Uncontrolled and Possible Severe Asthma in Denmark","status":"UNKNOWN","sponsor":"Copenhagen University Hospital, Hvidovre","startDate":"2022-10","conditions":"Asthma","enrollment":550},{"nctId":"NCT02948959","phase":"PHASE3","title":"Evaluation of Dupilumab in Children With Uncontrolled Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2017-04-21","conditions":"Asthma","enrollment":408},{"nctId":"NCT02134028","phase":"PHASE3","title":"Long-Term Safety Evaluation of Dupilumab in Patients With Asthma (LIBERTY ASTHMA TRAVERSE)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2014-08-05","conditions":"Asthma","enrollment":2282},{"nctId":"NCT03187119","phase":"NA","title":"Investigation of the Role of Pictorial Asthma Action Plans to Promote Self-management in Rural Youth With Asthma","status":"COMPLETED","sponsor":"West Virginia University","startDate":"2017-05-24","conditions":"Asthma","enrollment":45},{"nctId":"NCT04179461","phase":"PHASE2","title":"Personalized Treatment Algorithms for Difficult-to-treat Asthma","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2018-03-16","conditions":"Asthma in Children","enrollment":21},{"nctId":"NCT01761630","phase":"","title":"The Severe Asthma Research Program III-Boston Clinical Site","status":"COMPLETED","sponsor":"Elliot Israel, MD","startDate":"2012-12","conditions":"Asthma","enrollment":126},{"nctId":"NCT03137043","phase":"","title":"Prevalence of Severe Asthma in Spanish Hospitals","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-11-22","conditions":"Asthma","enrollment":356},{"nctId":"NCT03884114","phase":"NA","title":"Comparison of Three Modalities to Assess Clinical Competence of Medical Students","status":"COMPLETED","sponsor":"Ilumens","startDate":"2019-03-20","conditions":"Educational Problems","enrollment":42},{"nctId":"NCT03860519","phase":"NA","title":"The Use of the Propeller Health Platform to Improve Inhaled Corticosteroid (ICS) Use Among Adults With Uncontrolled Persistent Asthma","status":"COMPLETED","sponsor":"Endeavor Health","startDate":"2018-03-07","conditions":"Asthma","enrollment":100},{"nctId":"NCT02528214","phase":"PHASE3","title":"Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-10-15","conditions":"Asthma","enrollment":210},{"nctId":"NCT03369847","phase":"PHASE4","title":"Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge","status":"COMPLETED","sponsor":"New York City Health and Hospitals Corporation","startDate":"2017-09-10","conditions":"Asthma, Pediatric ALL","enrollment":43},{"nctId":"NCT03921268","phase":"PHASE1","title":"Study to Assess Effect of Device and Formulation on Pharmacokinetics (PK) of AZD1402","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2019-03-25","conditions":"Asthma","enrollment":18},{"nctId":"NCT03791658","phase":"NA","title":"Assessment of Adherence to Controller Inhalation Medication in Asthma- and COPD Patients.","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2019-01-02","conditions":"Asthma, COPD, Adherence, Medication","enrollment":141},{"nctId":"NCT02537691","phase":"PHASE4","title":"Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2015-08-28","conditions":"Asthma","enrollment":483},{"nctId":"NCT02414854","phase":"PHASE3","title":"Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-04-27","conditions":"Asthma","enrollment":1902},{"nctId":"NCT02298205","phase":"PHASE4","title":"Asthma Symptom Based Adjustment of Inhaled Steroid Therapy in African American Children","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2015-02","conditions":"Asthma","enrollment":206},{"nctId":"NCT02720081","phase":"PHASE2","title":"Study of MK-1029 in Participants With Persistent Asthma That Cannot Be Controlled With Montelukast (MK-1029-015)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2016-05-11","conditions":"Asthma","enrollment":142},{"nctId":"NCT02281318","phase":"PHASE3","title":"Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Participants With Severe Eosinophilic Asthma on Markers of Asthma Control","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-12-11","conditions":"Asthma","enrollment":556},{"nctId":"NCT02099656","phase":"PHASE2","title":"A Study Evaluating the Effects of Lebrikizumab on Airway Eosinophilic Inflammation in Participants With Uncontrolled Asthma","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2014-11-06","conditions":"Asthma","enrollment":64},{"nctId":"NCT01346852","phase":"","title":"Predictive Ability of Therapeutic Risk Factors in Pediatric and Adult Asthma Patients","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-07","conditions":"Asthma","enrollment":101437},{"nctId":"NCT01867125","phase":"PHASE3","title":"A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2013-07-31","conditions":"Asthma","enrollment":1081},{"nctId":"NCT01868061","phase":"PHASE3","title":"A Study of Lebrikizumab in Participants With Uncontrolled Asthma on Inhaled Corticosteroids and a Second Controller Medication","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2013-07-31","conditions":"Asthma","enrollment":1068},{"nctId":"NCT01875003","phase":"PHASE3","title":"A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2013-08-31","conditions":"Asthma","enrollment":348},{"nctId":"NCT01383941","phase":"","title":"Asthma Phenotypes in the Inner City","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-08","conditions":"Asthma, Rhinitis","enrollment":717},{"nctId":"NCT01634152","phase":"PHASE3","title":"Efficacy and Safety of 2 Doses of Tiotropium Respimat® Compared to Placebo in Children With Severe Persistent Asthma","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2012-07","conditions":"Asthma","enrollment":401},{"nctId":"NCT00294398","phase":"NA","title":"Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2006-03","conditions":"Asthma","enrollment":152},{"nctId":"NCT01277523","phase":"PHASE3","title":"Efficacy and Safety of 2 Doses of Tiotropium Respimat Compared to Placebo in Adolescents With Severe Persistent Asthma","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2011-01","conditions":"Asthma","enrollment":392},{"nctId":"NCT00776984","phase":"PHASE3","title":"Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study II)","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2008-10","conditions":"Asthma","enrollment":453},{"nctId":"NCT00772538","phase":"PHASE3","title":"Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study I)","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2008-10","conditions":"Asthma","enrollment":459},{"nctId":"NCT01696071","phase":"PHASE2","title":"Comparison of Two Daily Dose Regimens of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for 4 Weeks on Top of Maintenance Therapy With Inhaled Corticosteroid Controller Medication","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2012-09","conditions":"Asthma","enrollment":98},{"nctId":"NCT00113633","phase":"NA","title":"Educational Video for Improving Follow-up After an Emergency Department Visit for Asthma","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2003-09","conditions":"Asthma","enrollment":439},{"nctId":"NCT01286532","phase":"","title":"Asthma in Children","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2011-04","conditions":"Asthma","enrollment":283},{"nctId":"NCT01055041","phase":"NA","title":"Controller Medications in the Management of Bronchial Asthma","status":"COMPLETED","sponsor":"Government Medical College, Bhavnagar","startDate":"2008-12","conditions":"Moderate to Severe Persistent Bronchial Asthma","enrollment":50},{"nctId":"NCT00641472","phase":"PHASE4","title":"Pulmicort Respules(Budesonide Inhalation Suspension) vs Singulair, Children","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2002-10","conditions":"Asthma","enrollment":380}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Asthma Controller Therapies","genericName":"Asthma Controller Therapies","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Asthma controller therapies work by reducing airway inflammation and preventing asthma symptoms through various mechanisms including corticosteroid action, leukotriene modulation, or biologic targeting of inflammatory pathways. Used for Asthma maintenance therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}